Advances in parasitology. Volume 108 /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Rollinson, D., Stothard, J. R. (J. Russell)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, 2020.
Colección:Issn Ser.
Temas:
Parasitology.
Parasitology
Parasitologie.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Advances in Parasitology
  • Copyright
  • Contents
  • Contributors
  • Chapter One: A perspective on the discovery of selected compounds with anthelmintic activity against the barber�s pole wo ...
  • 1. Introduction
  • 1.1. Treatment, control and problems associated with anthelmintic resistance
  • 1.2. Anthelmintic drug discovery
  • 1.2.1. Mechanism-based screening
  • 1.2.2. Whole-worm screening
  • 1.3. Selection of compound collections for anthelmintic drug discovery
  • 1.3.1. Discovering new chemical entities
  • 1.3.2. Drug repurposing
  • 1.4. Use of molecular and informatic technologies to assist anthelmintic discovery
  • 2. Recent progress through the screening of compounds against larval stages of H. contortus in vitro
  • 2.1. A novel chemical entity (SN00797439) with selective anthelmintic activity
  • 2.2. Kinase inhibitors
  • 2.3. Tolfenpyrad: An approved pesticide
  • 2.4. Pyrazole-5-carboxamide derivatives
  • 2.5. Tetrahydroquinoxalines
  • 3. Discussion and conclusions
  • 3.1. Issues relating to screening methods
  • 3.1.1. Motility reduction as a measure to detect hits and its limitations
  • 3.1.2. Extending screens to adult worms
  • 3.2. Considerations regarding compound libraries
  • 3.3. Evaluating `hit compounds
  • 3.3.1. Inhibition of larval motility and development
  • 3.3.2. Cytotoxicity testing
  • 3.4. Potential of selected compounds as future `leads
  • 3.4.1. Pyrazole-5-carboxamides
  • 3.4.2. Kinase inhibitors
  • 3.4.3. Compound SN00797439
  • 3.5. Toward anthelmintic development
  • 3.5.1. Chemical optimisation
  • 3.5.2. Pharmacokinetic properties
  • 3.5.3. Spectrum of activity
  • 3.5.4. Mode of action and resistance development
  • 3.6. Concluding remarks
  • Acknowledgements
  • 2.3.7. Diphyllobothrium
  • 2.3.8. Hymenolepis
  • 3. Risk factors for infection with zoonotic helminths
  • 3.1. Environmental exposure
  • 3.2. Sanitation, hygiene and food preparation
  • 3.3. Farming and animal husbandry
  • 3.4. Companion animals
  • 4. Molecular insights into helminth transmission
  • 4.1. Molecular diagnosis of helminth infection in the host
  • 4.2. Helminth speciation and identification of reservoirs
  • 4.2.1. Ascaris
  • 4.2.2. Hookworms
  • 4.2.3. Paragonimus
  • 4.2.4. Fasciola
  • 4.2.5. Taenia
  • 4.2.6. Schistosoma
  • 4.3. Environmental DNA

Ejemplares similares