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|a 616.96
|2 23
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|a Advances in parasitology.
|n Volume 108 /
|c edited by David Rollinson, Russell Stothard.
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| 260 |
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|a London :
|b Academic Press,
|c 2020.
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| 300 |
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
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|a online resource
|b cr
|2 rdacarrier
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1 |
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|a Issn Ser.
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|a References-Further reading-Chapter Two: Zoonotic transmission of intestinal helminths in southeast Asia: Implications for control and elimination-1. Introduction-2. Zoonotic intestinal helminths in SEA-2.1. Soil transmitted helminths-2.2. Schistosomes-2.3. Foodborne helminths-2.3.1. Capillaria-2.3.2. Trichinella-2.3.3. Angiostrongylus cantonensis-2.3.4. Anisakis-2.3.5. Foodborne trematodes-2.3.5.1. Lung fluke: Paragonimus-2.3.5.2. Minute intestinal flukes-2.3.5.3. Liver fluke: Opithorcis and Clonorchis-2.3.5.4. Liver fluke: Fasciola-2.3.6. Taenia
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|a Intro -- Advances in Parasitology -- Copyright -- Contents -- Contributors -- Chapter One: A perspective on the discovery of selected compounds with anthelmintic activity against the barber�s pole wo ... -- 1. Introduction -- 1.1. Treatment, control and problems associated with anthelmintic resistance -- 1.2. Anthelmintic drug discovery -- 1.2.1. Mechanism-based screening -- 1.2.2. Whole-worm screening -- 1.3. Selection of compound collections for anthelmintic drug discovery -- 1.3.1. Discovering new chemical entities -- 1.3.2. Drug repurposing
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|a 1.4. Use of molecular and informatic technologies to assist anthelmintic discovery -- 2. Recent progress through the screening of compounds against larval stages of H. contortus in vitro -- 2.1. A novel chemical entity (SN00797439) with selective anthelmintic activity -- 2.2. Kinase inhibitors -- 2.3. Tolfenpyrad: An approved pesticide -- 2.4. Pyrazole-5-carboxamide derivatives -- 2.5. Tetrahydroquinoxalines -- 3. Discussion and conclusions -- 3.1. Issues relating to screening methods -- 3.1.1. Motility reduction as a measure to detect hits and its limitations
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|a 3.1.2. Extending screens to adult worms -- 3.2. Considerations regarding compound libraries -- 3.3. Evaluating `hit compounds -- 3.3.1. Inhibition of larval motility and development -- 3.3.2. Cytotoxicity testing -- 3.4. Potential of selected compounds as future `leads -- 3.4.1. Pyrazole-5-carboxamides -- 3.4.2. Kinase inhibitors -- 3.4.3. Compound SN00797439 -- 3.5. Toward anthelmintic development -- 3.5.1. Chemical optimisation -- 3.5.2. Pharmacokinetic properties -- 3.5.3. Spectrum of activity -- 3.5.4. Mode of action and resistance development -- 3.6. Concluding remarks -- Acknowledgements
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|a 2.3.7. Diphyllobothrium -- 2.3.8. Hymenolepis -- 3. Risk factors for infection with zoonotic helminths -- 3.1. Environmental exposure -- 3.2. Sanitation, hygiene and food preparation -- 3.3. Farming and animal husbandry -- 3.4. Companion animals -- 4. Molecular insights into helminth transmission -- 4.1. Molecular diagnosis of helminth infection in the host -- 4.2. Helminth speciation and identification of reservoirs -- 4.2.1. Ascaris -- 4.2.2. Hookworms -- 4.2.3. Paragonimus -- 4.2.4. Fasciola -- 4.2.5. Taenia -- 4.2.6. Schistosoma -- 4.3. Environmental DNA
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| 650 |
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|a Parasitology.
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| 650 |
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2 |
|a Parasitology
|0 (DNLM)D010274
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| 650 |
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6 |
|a Parasitologie.
|0 (CaQQLa)201-0024233
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| 650 |
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7 |
|a Parasitology
|2 fast
|0 (OCoLC)fst01053186
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| 700 |
1 |
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|a Rollinson, D.
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| 700 |
1 |
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|a Stothard, J. R.
|q (J. Russell)
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| 776 |
0 |
8 |
|i Print version:
|z 0128207507
|z 9780128207505
|w (OCoLC)1122909156
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| 830 |
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0 |
|a Issn Ser.
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| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/0065308X/108
|z Texto completo
|
