Recent advances in Parkinson's disease /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bj�orklund, Anders, 1945- (Editor ), Cenci, M. Angela (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, 2020.
Colección:Progress in brain research ; v. 252.
Temas:
Parkinson's disease.
Parkinson Disease
Maladie de Parkinson.
Internet Resources.
Index not Present.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Recent Advances in Parkinson's Disease
  • Copyright
  • Contributors
  • Contents
  • Preface: The evolving scenario of Parkinson�s research
  • Part I: Basic Science
  • Chapter 1: What we can learn from iPSC-derived cellular models of Parkinson's disease
  • 1. Introduction
  • 2. Establishment of iPSC technology and methods of differentiation into DAns
  • 2.1. Establishment of induced pluripotent stem cells
  • 2.2. Differentiation into DAns
  • 3. iPSC-derived neurons for disease modeling
  • 3.1. Endoplasmic reticulum stress
  • 3.2. Protein trafficking and degradation deficits
  • 3.3. Mitochondrial defects and oxidative stress
  • 3.4. Alterations in calcium homeostasis
  • 4. iPSC-derived glial cells for disease modeling
  • 5. Co-culture systems, 3D cultures and organoids for disease modeling
  • 6. iPSC-derived neurons for cell-based treatments
  • 7. Limitations of iPSC-based models
  • 8. Future applications
  • 9. Conclusions
  • Acknowledgments
  • References
  • Chapter 2: Animal models for preclinical Parkinson's research: An update and critical appraisal
  • 1. Introduction
  • 2. Models in different species
  • 3. The importance of nigrostriatal dopaminergic degeneration
  • 4.3. Tertiary and quaternary structure of aSyn
  • 4.4. The effect of PD-associated mutations in aSyn
  • 4.5. Post-translational modifications
  • 5. Alpha-synuclein pathology in the synapse
  • 6. aSyn pathology in mitochondria
  • 7. aSyn pathology in the ER-Golgi compartments
  • 7.1. Degradation and clearance of aSyn
  • 7.2. aSyn pathology and the cytoskeleton
  • 7.3. Effects of aSyn in the nucleus
  • 8. Spreading of aSyn pathology
  • 9. The interplay between aSyn and the microbiome
  • 10. Inflammation
  • 11. Conclusions and outlook
  • Acknowledgments
  • References

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