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Recent advances in Parkinson's disease /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bj�orklund, Anders, 1945- (Editor ), Cenci, M. Angela (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, 2020.
Colección:Progress in brain research ; v. 252.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Recent advances in Parkinson's disease /  |c edited by Anders Bj�orklund, M. Angela Cenci. 
260 |a Amsterdam :  |b Academic Press,  |c 2020. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Progress in brain research ;  |v v. 252 
505 0 |a Intro -- Recent Advances in Parkinson's Disease -- Copyright -- Contributors -- Contents -- Preface: The evolving scenario of Parkinson�s research -- Part I: Basic Science -- Chapter 1: What we can learn from iPSC-derived cellular models of Parkinson's disease -- 1. Introduction -- 2. Establishment of iPSC technology and methods of differentiation into DAns -- 2.1. Establishment of induced pluripotent stem cells -- 2.2. Differentiation into DAns -- 3. iPSC-derived neurons for disease modeling -- 3.1. Endoplasmic reticulum stress -- 3.2. Protein trafficking and degradation deficits 
505 8 |a 3.3. Mitochondrial defects and oxidative stress -- 3.4. Alterations in calcium homeostasis -- 4. iPSC-derived glial cells for disease modeling -- 5. Co-culture systems, 3D cultures and organoids for disease modeling -- 6. iPSC-derived neurons for cell-based treatments -- 7. Limitations of iPSC-based models -- 8. Future applications -- 9. Conclusions -- Acknowledgments -- References -- Chapter 2: Animal models for preclinical Parkinson's research: An update and critical appraisal -- 1. Introduction -- 2. Models in different species -- 3. The importance of nigrostriatal dopaminergic degeneration 
505 8 |a 4.3. Tertiary and quaternary structure of aSyn -- 4.4. The effect of PD-associated mutations in aSyn -- 4.5. Post-translational modifications -- 5. Alpha-synuclein pathology in the synapse -- 6. aSyn pathology in mitochondria -- 7. aSyn pathology in the ER-Golgi compartments -- 7.1. Degradation and clearance of aSyn -- 7.2. aSyn pathology and the cytoskeleton -- 7.3. Effects of aSyn in the nucleus -- 8. Spreading of aSyn pathology -- 9. The interplay between aSyn and the microbiome -- 10. Inflammation -- 11. Conclusions and outlook -- Acknowledgments -- References 
650 0 |a Parkinson's disease. 
650 2 |a Parkinson Disease  |0 (DNLM)D010300 
650 6 |a Maladie de Parkinson.  |0 (CaQQLa)201-0016037 
650 7 |a Parkinson's disease.  |2 fast  |0 (OCoLC)fst01053693 
655 4 |a Internet Resources. 
655 4 |a Index not Present. 
700 1 |a Bj�orklund, Anders,  |d 1945-  |e editor. 
700 1 |a Cenci, M. Angela,  |e editor. 
776 0 8 |i Print version:  |t Recent advances in Parkinson's disease.  |d Amsterdam : Academic Press, 2020  |z 0444642609  |z 9780444642608  |w (OCoLC)1111968015 
830 0 |a Progress in brain research ;  |v v. 252. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/00796123/252  |z Texto completo