Tabla de Contenidos:
  • Front Cover
  • Principles of Tissue Engineering
  • Copyright Page
  • Contents
  • List of contributors
  • Preface
  • 1 Tissue engineering: current status and future perspectives
  • Clinical need
  • Current state of the field
  • Smart biomaterials
  • Cell sources
  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Adult stem cells
  • Whole organ engineering
  • Biofabrication technologies
  • Electrospinning
  • Inkjet three-dimensional bioprinting
  • Extrusion three-dimensional bioprinting
  • Spheroids and organoids
  • Imaging technologies
  • Tissue neovascularization
  • Bioreactors
  • Organ-on-a-chip and body-on-a-chip
  • Integration of nanotechnology
  • Current challenges
  • Future directions
  • Smart biomaterials
  • Cell sources
  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Adult stem cells
  • Whole organ engineering
  • Biofabrication technologies
  • Tissue neovasculatization
  • Bioreactors
  • Integration of nanotechnology
  • Conclusions and future challenges
  • References
  • Further reading
  • 2 From mathematical modeling and machine learning to clinical reality
  • Introduction
  • Modeling stem cell dynamics
  • Positive feedback-based molecular switches
  • Variability in stem cell populations
  • Modeling tissue growth and development
  • Monolayer tissue growth in vitro
  • Tissue growth on complex surfaces in vitro
  • Three-dimensional tissue growth in vitro
  • Pattern formation
  • Machine learning in tissue engineering
  • Supervised methods
  • Unsupervised methods
  • Machine learning of cellular dynamics
  • Regulatory network inference
  • From mathematical models to clinical reality
  • References
  • 3 Moving into the clinic
  • Introduction
  • Current state of tissue engineering
  • Pathway for clinical translation
  • Regulatory considerations for tissue engineering
  • Conclusion
  • Acknowledgment
  • References
  • Further reading
  • One: The basis of growth and differentiation
  • 4 Molecular biology of the cell
  • The cell nucleus
  • Control of gene expression
  • Transcription factors
  • Other controls of gene activity
  • The cytoplasm
  • The cytoskeleton
  • Microtubules
  • Microfilaments
  • Small GTPases
  • The cell surface
  • Cell adhesion molecules
  • Extracellular matrix
  • Signal transduction
  • Growth and death
  • Culture media
  • Cells in tissues and organs
  • Cell types
  • Tissues
  • Organs
  • Reference
  • Further reading
  • General
  • Chromatin
  • Signaling, general
  • Cytoskeleton, adhesion molecules and extracellular matrix
  • 5 Molecular organization of cells
  • Introduction
  • Molecules that organize cells
  • Changes in cell-cell adhesion
  • Changes in celleextracellular matrix adhesion
  • Changes in cell polarity and stimulation of cell motility
  • Invasion of the basal lamina
  • The epithelial-mesenchymal transition transcriptional program
  • Transcription factors that regulate epithelial-mesenchymal transition
  • Regulation at the promoter level