Stem cell proliferation and differentiation /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Fazzio, Thomas G. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2020.
Colección:Current topics in developmental biology ; 138.
Temas:
Stem cells.
Cell proliferation.
Cell differentiation.
Stem Cells
Cell Differentiation
Cell Proliferation
Cellules souches.
Cellules > Prolif�eration.
Cellules > Diff�erenciation.
Cell differentiation
Cell proliferation
Stem cells
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Stem Cell Proliferation and Differentiation
  • Copyright
  • Contents
  • Contributors
  • Preface
  • 1. Chromatin regulation and dynamics
  • 2. Long noncoding RNAs and RNA-binding proteins
  • 3. Distinct modes of pluripotency
  • 4. Differentiation of pluripotent stem cells
  • 5. Metabolic control of cell state
  • 6. Conclusions and perspectives
  • Chapter One: Chromatin regulation and dynamics in stem cells
  • 1. Chromatin compaction, structure, and function
  • 1.1. Nucleosomes are formed from DNA interacting with an octamer of four histone proteins
  • 1.2. Chromatin structure balances DNA compaction and accessibility
  • 2. Chromatin dynamics regulate gene expression
  • 3. ATP-dependent nucleosome remodeling complexes establish and maintain chromatin state
  • 3.1. SWI/SNF family nucleosome remodeling factors
  • 3.2. INO80 family nucleosome remodeling factors
  • 3.3. ISWI family nucleosome remodeling factors
  • 3.4. CHD family nucleosome remodeling factors
  • 3.5. Summary
  • 4. Histone modifications provide an additional layer of gene regulation
  • 4.1. Histone acetylation and deacetylation
  • 4.2. Histone methylation and demethylation
  • 4.3. Polycomb group proteins mediate H3K27me3 and silencing of developmental genes
  • 5. Histone chaperones and histone variants regulate chromatin structure
  • 6. Histone H2A variants
  • 6.1. H2A.Z is a histone variant associated with active transcription
  • 6.2. H2A.X is a marker of DNA double-strand breaks
  • 6.3. macroH2A is associated with repression and heterochromatin
  • 7. Histone H3 variants
  • 7.1. H3.3 marks regulatory, repetitive, and actively transcribed regions
  • 7.2. CENP-A is a centromere-specific variant of histone H3
  • 8. Histone chaperones
  • 8.1. FACT facilitates H2A/H2B dimer exchange to promote nucleosome-templated activities
  • 8.2. CAF1 and ASF1 promote incorporation of H3 and H4 onto newly synthesized DNA
  • 8.3. HIRA deposits H3.3 at actively transcribed and regulatory regions of chromatin
  • 8.4. ATRX/DAXX deposit H3.3 at telomeres and pericentric heterochromatin
  • 8.5. The NAP1 family import newly translated histones from the cytoplasm to the nucleus
  • 8.6. INO80 family members possess both nucleosome remodeling and histone chaperone activities
  • 9. Chromatin structure is dynamic and highly regulated
  • 10. Stem cell chromatin is dynamic and tuned to regulate cell fate
  • 11. ES cells carefully regulate their chromatin via specialized transcription factors
  • 11.1. Master regulators of pluripotency
  • 11.2. Pioneer transcription factors
  • 12. Embryonic stem cell chromatin is poised for action
  • 13. Histone modifications are specifically regulated in stem cells to maintain pluripotency and facilitate differentiation
  • 13.1. H3K56ac regulates pluripotency factors and developmental regulators
  • 13.2. Bivalent promoters mark lowly expressed but poised genes in ES cells

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