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SCIDIR_on1146560602 |
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OCoLC |
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20231120010444.0 |
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m o d |
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cr |n||||||||| |
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200330s2020 mau o 000 0 eng d |
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|a YDX
|b eng
|e pn
|c YDX
|d OPELS
|d EBLCP
|d UKAHL
|d OHS
|d OCLCO
|d OCLCF
|d N$T
|d CUS
|d OCLCA
|d OCLCQ
|d OCLCO
|d OCLCQ
|d OCLCO
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| 020 |
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|a 9780128128916
|q (electronic bk.)
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| 020 |
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|a 0128128917
|q (electronic bk.)
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| 020 |
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|z 9780128128909
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| 020 |
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|z 0128128909
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| 035 |
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|a (OCoLC)1146560602
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| 050 |
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4 |
|a QH588.S83
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| 082 |
0 |
4 |
|a 616.02/774
|2 23
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| 245 |
0 |
0 |
|a Stem cell proliferation and differentiation /
|c edited by Thomas G. Fazzio.
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| 260 |
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|a Cambridge, MA :
|b Academic Press,
|c 2020.
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| 300 |
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|a 1 online resource
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Current Topics in Developmental Biology ;
|v 138
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| 505 |
0 |
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|a Intro -- Stem Cell Proliferation and Differentiation -- Copyright -- Contents -- Contributors -- Preface -- 1. Chromatin regulation and dynamics -- 2. Long noncoding RNAs and RNA-binding proteins -- 3. Distinct modes of pluripotency -- 4. Differentiation of pluripotent stem cells -- 5. Metabolic control of cell state -- 6. Conclusions and perspectives -- Chapter One: Chromatin regulation and dynamics in stem cells -- 1. Chromatin compaction, structure, and function -- 1.1. Nucleosomes are formed from DNA interacting with an octamer of four histone proteins
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| 505 |
8 |
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|a 1.2. Chromatin structure balances DNA compaction and accessibility -- 2. Chromatin dynamics regulate gene expression -- 3. ATP-dependent nucleosome remodeling complexes establish and maintain chromatin state -- 3.1. SWI/SNF family nucleosome remodeling factors -- 3.2. INO80 family nucleosome remodeling factors -- 3.3. ISWI family nucleosome remodeling factors -- 3.4. CHD family nucleosome remodeling factors -- 3.5. Summary -- 4. Histone modifications provide an additional layer of gene regulation -- 4.1. Histone acetylation and deacetylation -- 4.2. Histone methylation and demethylation
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| 505 |
8 |
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|a 4.3. Polycomb group proteins mediate H3K27me3 and silencing of developmental genes -- 5. Histone chaperones and histone variants regulate chromatin structure -- 6. Histone H2A variants -- 6.1. H2A.Z is a histone variant associated with active transcription -- 6.2. H2A.X is a marker of DNA double-strand breaks -- 6.3. macroH2A is associated with repression and heterochromatin -- 7. Histone H3 variants -- 7.1. H3.3 marks regulatory, repetitive, and actively transcribed regions -- 7.2. CENP-A is a centromere-specific variant of histone H3 -- 8. Histone chaperones
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| 505 |
8 |
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|a 8.1. FACT facilitates H2A/H2B dimer exchange to promote nucleosome-templated activities -- 8.2. CAF1 and ASF1 promote incorporation of H3 and H4 onto newly synthesized DNA -- 8.3. HIRA deposits H3.3 at actively transcribed and regulatory regions of chromatin -- 8.4. ATRX/DAXX deposit H3.3 at telomeres and pericentric heterochromatin -- 8.5. The NAP1 family import newly translated histones from the cytoplasm to the nucleus -- 8.6. INO80 family members possess both nucleosome remodeling and histone chaperone activities -- 9. Chromatin structure is dynamic and highly regulated
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| 505 |
8 |
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|a 10. Stem cell chromatin is dynamic and tuned to regulate cell fate -- 11. ES cells carefully regulate their chromatin via specialized transcription factors -- 11.1. Master regulators of pluripotency -- 11.2. Pioneer transcription factors -- 12. Embryonic stem cell chromatin is poised for action -- 13. Histone modifications are specifically regulated in stem cells to maintain pluripotency and facilitate differentiation -- 13.1. H3K56ac regulates pluripotency factors and developmental regulators -- 13.2. Bivalent promoters mark lowly expressed but poised genes in ES cells
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| 650 |
|
0 |
|a Stem cells.
|
| 650 |
|
0 |
|a Cell proliferation.
|
| 650 |
|
0 |
|a Cell differentiation.
|
| 650 |
|
2 |
|a Stem Cells
|0 (DNLM)D013234
|
| 650 |
|
2 |
|a Cell Differentiation
|0 (DNLM)D002454
|
| 650 |
|
2 |
|a Cell Proliferation
|0 (DNLM)D049109
|
| 650 |
|
6 |
|a Cellules souches.
|0 (CaQQLa)201-0058821
|
| 650 |
|
6 |
|a Cellules
|x Prolif�eration.
|0 (CaQQLa)201-0005059
|
| 650 |
|
6 |
|a Cellules
|x Diff�erenciation.
|0 (CaQQLa)201-0030846
|
| 650 |
|
7 |
|a Cell differentiation
|2 fast
|0 (OCoLC)fst00850182
|
| 650 |
|
7 |
|a Cell proliferation
|2 fast
|0 (OCoLC)fst00850224
|
| 650 |
|
7 |
|a Stem cells
|2 fast
|0 (OCoLC)fst01132975
|
| 700 |
1 |
|
|a Fazzio, Thomas G.,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|z 0128128909
|z 9780128128909
|w (OCoLC)1119625206
|
| 830 |
|
0 |
|a Current topics in developmental biology ;
|v 138.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/00702153/138
|z Texto completo
|
