Giardia and giardiasis. Part B /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Ortega-Pierres, Guadalupe (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, 2020.
Colección:Advances in parasitology ; v. 107.
Temas:
Giardia.
Giardiasis.
Giardia
Giardiasis
Lambliase.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Giardia and Giardiasis, Part B
  • Copyright
  • Dedication
  • Contents
  • Contributors
  • Preface
  • Chapter One: The structural organization of Giardia intestinalis cytoskeleton
  • 1. Introduction
  • 2. Giardia cytoskeleton structures
  • 2.1. Ventral disc
  • 2.2. Flagella and accessory structures
  • 2.3. Median body
  • 2.4. Actin filaments
  • 3. Cytoskeleton during cell differentiation
  • 4. Concluding remarks
  • Acknowledgements
  • References
  • Further reading
  • Chapter Two: Microtubule organelles in Giardia
  • 1. Introduction
  • 2. Conserved and novel composition of the MT cytoskeleton
  • 3. Complex architecture and composition of the ventral disc
  • 4. Mechanisms of ventral disc-mediated attachment
  • 5. The structure and putative functions of the median body
  • 6. Flagella and basal body architecture and composition
  • 7. Putative functions of axoneme-associated structures
  • 8. Flagellar motility and role during the life cycle
  • 9. Flagellar assembly and equilibrium length maintenance
  • 10. Assembly and inheritance of MT organelles during cell division
  • 11. Assembly and inheritance of organelles during encystation and excystation
  • 12. Perspectives for future studies of Giardia�s MT organelles
  • Acknowledgements
  • References
  • Chapter Three: Recent advances in functional research in Giardia intestinalis
  • 1. Introduction
  • 2. Advances in in vitro cultivation
  • 2.1. Systems for studies of Giardia-host cell interactions in vitro and in vivo
  • 3. Major knowledge gaps in functional biology in Giardia
  • 4. Computational and ``omic�� approaches to functional biology research in Giardia
  • 4.1. In silico inference of function
  • 4.2. Applying systems biology to function studies
  • 5. Direct, targeted-based assessment of gene function
  • 5.1. Transfection vectors in Giardia and their use in studies of Giardia biology and pathogenesis
  • 5.2. Creating robust and stable gene knockdown strains with CRISPR interference
  • 5.3. Using CRISPRi to study basic and pathogenic aspects of Giardia biology
  • 5.4. In vivo bioluminescent imaging of Giardia infection dynamics in small animal models
  • 6. Concluding remarks
  • Acknowledgements
  • References
  • Chapter Four: Transcriptomic and proteomic analyses of Giardia intestinalis: Intestinal epithelial cell interactions
  • 1. Introduction
  • 2. In vitro models of Giardia-host cell interactions
  • 3. Transcriptomic analyses of IEC gene expression during Giardia interactions
  • 4. Transcriptomic analyses of parasite gene expression during IEC interactions
  • 5. Proteomic analyses of Giardia-IEC interactions
  • 6. Summary of 'omics-based' studies of Giardia-IEC interactions
  • 7. Future directions
  • Acknowledgements
  • References

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