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PROTEIN HOMEOSTASIS DISEASES mechanisms and novel therapies.
Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeos...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[S.l.] :
ELSEVIER ACADEMIC PRESS,
[2020]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover
- Title page
- Copyright page
- Contents
- Contributors
- Preface
- Section I
- Introduction of protein folding and homeostasis
- Chapter 1
- Protein folding: how, why, and beyond
- Outline
- Introduction
- Protein conformational landscapes
- Mutational perturbations to probe folding mechanisms and function
- Disordered proteins-regions and unfolded states
- Folding, stability, and binding in vivo
- "Real proteins" and beyond
- Acknowledgments
- References
- Chapter 2
- Protein homeostasis and disease
- Outline
- Abbreviations
- Protein folding in vitro and in vivo
- Effects of intracellular milieu composition on protein folding, misfolding, and stability in vivo
- The first steps of in vivo folding and misfolding in the ribosomes: cotranslational versus posttranslational processes
- Protein homeostasis networks
- Molecular chaperones
- Protein degradation: proteasome versus autophagy
- Human misfolding diseases
- Loss-of-function diseases
- Gain-of-toxic function diseases
- Acknowledgments
- Conflict of interest
- Funding
- References
- Section II
- Protein folding and homeostasis at the organismal and proteomic scales
- Utility of Caenorhabditis elegans Alzheimer's disease models for drug discovery and identification of genetic modifiers
- Tauopathies
- Disease mechanism
- Caenorhabditis elegans models of tauopathy
- Utility of Caenorhabditis elegans tauopathy models for drug discovery and identification of genetic modifiers
- Parkinson's disease
- Disease mechanism
- Caenorhabditis elegans Parkinson's disease models
- Utility of Caenorhabditis elegans Parkinson's disease models for drug discovery and identification of genetic modifiers
- Polyglutamine diseases
- Disease mechanism
- Caenorhabditis elegans models of Huntington's disease
- Utility of Caenorhabditis elegans HD models for drug discovery and identification of genetic modifiers
- Caenorhabditis elegans models of spinocerebellar ataxia
- Utility of Caenorhabditis elegans spinocerebellar ataxia models for drug discovery and identification of genetic modifiers
- Amyotrophic lateral sclerosis
- Disease mechanism
- Caenorhabditis elegans models of amyotrophic lateral sclerosis
- Transthyretin amyloidosis
- Disease mechanism
- Caenorhabditis elegans disease models of transthyretin amyloidosis