Medicinal chemistry /

"Medicinal Chemistry, Volume 75, the latest release in the Advances in Inorganic Chemistry series, presents timely and informative summaries on current progress in a variety of subject areas. This acclaimed serial features reviews written by experts in the field, serving as an indispensable ref...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Sadler, P. J. (Editor ), Eldik, Rudi van (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press is an imprint of Elsevier, 2020.
Colección:Advances in inorganic chemistry ; v. 75.
Temas:
Pharmaceutical chemistry.
Chemistry, Pharmaceutical
Chimie pharmaceutique.
SCIENCE > Chemistry > Inorganic.
SCIENCE > Chemistry > General.
SCIENCE > Chemistry > Organic.
Pharmaceutical chemistry
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Medicinal Chemistry
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Feature Article
  • Chapter One: 150 years of the periodic table: New medicines and diagnostic agents
  • 1. Introduction
  • 1.1. Mendeleev�s elements
  • 1.2. Essential elements for human beings
  • 1.3. Minerals and metals in medicine
  • 2. Transferrin: Transport and delivery of iron and metallodrugs
  • 2.1. Titanium transferrin
  • 2.2. Bismuth transferrin
  • 2.3. Bacterial transferrin-metal clusters
  • 3. Metal complexes as imaging probes
  • 3.1. MRI contrast agents
  • 3.2. Metal-based radiopharmaceuticals
  • 3.2.1. Metals in radiotherapy
  • 4. Design of metallodrugs
  • 4.1. Gold complexes
  • 4.2. Ruthenium anticancer complexes
  • 4.3. Catalytic organometallic complexes
  • 4.3.1. Transfer hydrogenation catalysts
  • 4.4. Redox-active osmium anticancer complexes
  • 4.5. Organo Rh(III) and Ir(III) anticancer complexes
  • 4.6. Photodynamic therapy (PDT) and photo-activated chemotherapy (PACT)
  • 4.6.1. Ruthenium(II) and iridium(III) complexes for PDT
  • 4.6.2. Platinum complexes for PACT
  • 4.7. Computational metal coordination chemistry
  • 4.8. Metallo-antibiotics
  • 5. Conclusions and future outlook
  • Acknowledgments
  • References
  • Chapter Two: Medicinal inorganic chemistry: New perspectives and targets for the periodic table
  • 1. Introduction
  • 2. The polynuclear platinum concept
  • 2.1. Substitution-inert polynuclear platinums. Non-covalent interactions on DNA
  • 2.1.1. Structural and biophysical studies
  • 2.1.2. Comparison with polyamines and minor groove binders
  • 2.1.2.1. DNA condensation effects
  • 2.1.3. DNA-protein interactions
  • 2.1.4. Cellular studies
  • 3. The extracellular matrix and bioinorganic chemistry
  • 3.1. Metalloglycomics
  • 3.1.1. Metalloglycomics. The case of TriplatinNC
  • 3.1.2. Assessment of PPC-GAG interactions. The interactions of TiplatinNC with heparin
  • 3.1.2.1. Direct assays: Isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR)
  • 3.1.2.2. Heparin vs DNA affinity
  • 3.1.3. The use of Fondaparinux
  • 3.1.4. Summary
  • 3.2. Metalloshielding and its consequences
  • 3.3. A new understanding of biological activity of polynuclear platinum complexes. Intrinsically dual-function anticancer ...
  • 3.4. Metalloglycomics and the periodic table
  • 4. The role of endogenous metal ions and metal complexes in angiogenesis and metastasis
  • 4.1. Manganese, integrin activation and oxidative stress
  • 4.2. Mn-proteoglycan interactions at the molecular level
  • 5. Conclusions and future perspectives
  • Acknowledgements
  • References
  • Chapter Three: Anti-cancer gold, platinum and iridium compounds with porphyrin and/or N-heterocyclic carbene ligand(s)
  • 1. Introduction
  • 2. Stable anti-cancer metal complexes with porphyrin and/or N-heterocyclic carbene (NHC) ligand(s)
  • 2.1. Anti-cancer gold(III) porphyrin compounds

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