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Medicinal chemistry /
"Medicinal Chemistry, Volume 75, the latest release in the Advances in Inorganic Chemistry series, presents timely and informative summaries on current progress in a variety of subject areas. This acclaimed serial features reviews written by experts in the field, serving as an indispensable ref...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2020.
|
| Colección: | Advances in inorganic chemistry ;
v. 75. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 003 | OCoLC | ||
| 005 | 20231120010437.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 200213s2020 mau ob 001 0 eng d | ||
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| 019 | |a 1140789182 |a 1152532152 | ||
| 020 | |a 9780128191972 |q (electronic bk.) | ||
| 020 | |a 012819197X |q (electronic bk.) | ||
| 020 | |a 0128191961 | ||
| 020 | |a 9780128191965 | ||
| 020 | |z 9780128191965 |q (print) | ||
| 035 | |a (OCoLC)1140509183 |z (OCoLC)1140789182 |z (OCoLC)1152532152 | ||
| 050 | 4 | |a RS403 | |
| 082 | 0 | 4 | |a 615.19 |2 23 |
| 245 | 0 | 0 | |a Medicinal chemistry / |c edited by Peter J. Sadler, Rudi van Eldik. |
| 264 | 1 | |a Cambridge, MA : |b Academic Press is an imprint of Elsevier, |c 2020. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in inorganic chemistry ; |v volume 75 | |
| 500 | |a Includes index. | ||
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover -- Medicinal Chemistry -- Copyright -- Contents -- Contributors -- Preface -- Feature Article -- Chapter One: 150 years of the periodic table: New medicines and diagnostic agents -- 1. Introduction -- 1.1. Mendeleev�s elements -- 1.2. Essential elements for human beings -- 1.3. Minerals and metals in medicine -- 2. Transferrin: Transport and delivery of iron and metallodrugs -- 2.1. Titanium transferrin -- 2.2. Bismuth transferrin -- 2.3. Bacterial transferrin-metal clusters -- 3. Metal complexes as imaging probes -- 3.1. MRI contrast agents | |
| 505 | 8 | |a 3.2. Metal-based radiopharmaceuticals -- 3.2.1. Metals in radiotherapy -- 4. Design of metallodrugs -- 4.1. Gold complexes -- 4.2. Ruthenium anticancer complexes -- 4.3. Catalytic organometallic complexes -- 4.3.1. Transfer hydrogenation catalysts -- 4.4. Redox-active osmium anticancer complexes -- 4.5. Organo Rh(III) and Ir(III) anticancer complexes -- 4.6. Photodynamic therapy (PDT) and photo-activated chemotherapy (PACT) -- 4.6.1. Ruthenium(II) and iridium(III) complexes for PDT -- 4.6.2. Platinum complexes for PACT -- 4.7. Computational metal coordination chemistry -- 4.8. Metallo-antibiotics | |
| 505 | 8 | |a 5. Conclusions and future outlook -- Acknowledgments -- References -- Chapter Two: Medicinal inorganic chemistry: New perspectives and targets for the periodic table -- 1. Introduction -- 2. The polynuclear platinum concept -- 2.1. Substitution-inert polynuclear platinums. Non-covalent interactions on DNA -- 2.1.1. Structural and biophysical studies -- 2.1.2. Comparison with polyamines and minor groove binders -- 2.1.2.1. DNA condensation effects -- 2.1.3. DNA-protein interactions -- 2.1.4. Cellular studies -- 3. The extracellular matrix and bioinorganic chemistry -- 3.1. Metalloglycomics | |
| 505 | 8 | |a 3.1.1. Metalloglycomics. The case of TriplatinNC -- 3.1.2. Assessment of PPC-GAG interactions. The interactions of TiplatinNC with heparin -- 3.1.2.1. Direct assays: Isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) -- 3.1.2.2. Heparin vs DNA affinity -- 3.1.3. The use of Fondaparinux -- 3.1.4. Summary -- 3.2. Metalloshielding and its consequences -- 3.3. A new understanding of biological activity of polynuclear platinum complexes. Intrinsically dual-function anticancer ... -- 3.4. Metalloglycomics and the periodic table | |
| 505 | 8 | |a 4. The role of endogenous metal ions and metal complexes in angiogenesis and metastasis -- 4.1. Manganese, integrin activation and oxidative stress -- 4.2. Mn-proteoglycan interactions at the molecular level -- 5. Conclusions and future perspectives -- Acknowledgements -- References -- Chapter Three: Anti-cancer gold, platinum and iridium compounds with porphyrin and/or N-heterocyclic carbene ligand(s) -- 1. Introduction -- 2. Stable anti-cancer metal complexes with porphyrin and/or N-heterocyclic carbene (NHC) ligand(s) -- 2.1. Anti-cancer gold(III) porphyrin compounds | |
| 520 | |a "Medicinal Chemistry, Volume 75, the latest release in the Advances in Inorganic Chemistry series, presents timely and informative summaries on current progress in a variety of subject areas. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers that empowers readers to pursue new developments in each field. Users will find this to be a comprehensive overview of recent findings and trends from the last decade that covers various kinds of inorganic topics, from theoretical oriented supramolecular chemistry, to the quest for accurate calculations of spin states in transition metals."--Publisher's web page (viewed February 10, 2020) | ||
| 650 | 0 | |a Pharmaceutical chemistry. | |
| 650 | 2 | |a Chemistry, Pharmaceutical |0 (DNLM)D002626 | |
| 650 | 6 | |a Chimie pharmaceutique. |0 (CaQQLa)201-0028674 | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Inorganic. |2 bisacsh | |
| 650 | 7 | |a SCIENCE |x Chemistry |x General. |2 bisacsh | |
| 650 | 7 | |a SCIENCE |x Chemistry |x Organic. |2 bisacsh | |
| 650 | 7 | |a Pharmaceutical chemistry |2 fast |0 (OCoLC)fst01060115 | |
| 700 | 1 | |a Sadler, P. J., |e editor. | |
| 700 | 1 | |a Eldik, Rudi van, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t MEDICINAL CHEMISTRY. |d [Place of publication not identified] : ELSEVIER ACADEMIC PRESS, 2020 |z 0128191961 |w (OCoLC)1111980259 |
| 830 | 0 | |a Advances in inorganic chemistry ; |v v. 75. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/08988838/75 |z Texto completo |