An innovative approach to understanding and treating cancer : targeting pH - from etiopathogenesis to new therapeutic avenues /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Koltai, Tomas
Otros Autores: Reshkin, Stephan J., Harguindey, Salvador
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, 2020.
Temas:
Cancer > Treatment > Technological innovations.
Neoplasms > therapy
Cancer > Treatment > Technological innovations
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • An Innovative Approach to Understanding and Treating Cancer: Targeting pH: From Etiopathogenesis to New Therapeutic Avenues
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Part I: Metabolism and pH physiopathology of cancer
  • Chapter 1: Introduction
  • Introductory words
  • The basics
  • The importance of pH in cancer
  • The evolving concept of pH in cancer
  • First phase
  • Second phase
  • Third phase
  • Fourth phase
  • Clinical implications
  • The objectives of this book
  • References
  • Chapter 2: Cancer metabolism
  • Introduction
  • The Warburg effect
  • The glycolytic phenotype
  • Targeting glycolytic enzymes in cancer
  • The lactate shuttle122
  • The pentose phosphate pathway
  • The lipogenic phenotype
  • Fatty acid synthase
  • The metabolism of invadopodia
  • Glutaminolytic phenotype
  • Serine phenotype
  • The acid-base balance in malignant tumors
  • The ROS problem
  • The pH paradigm and metabolic changes in cancer
  • Multitargeted attack on tumor metabolism
  • Conclusions
  • References
  • Chapter 3: The pH-centered paradigm in cancer
  • Part I: The pH paradigm in cancer. Introduction
  • Common view points or perceptions of cancer origin and progression
  • The pH paradigm in cancer: Extracellular acidity, intracellular alkalinity and the pH gradient
  • Effects of pH gradient inversion in cancer
  • Intracellular alkalinity
  • Extracellular acidity
  • The pH gradient inversion
  • The hypoxia-pH gradient inversion relationship
  • Can hypoxia act as a carcinogenic agent by itself independently of genetic instability?
  • Hypoxia and pH gradient inversion
  • Clinical impact of the pH centered paradigm in cancer therapeutics
  • Some examples of how increasing pHe improves therapeutic results
  • Conclusions Part I
  • Part II: Why and how does the pH-centered paradigm develop in cancer?
  • The role of hypoxia in cancer metabolism and growth
  • Metabolic switch and pH abnormalities
  • Mechanisms that create an acidic extracellular matrix and an alkaline intracellular milieu
  • New therapeutic directions derived from the pH-centered paradigm
  • Why is pHe so acid and pHi alkaline in cancer cells?
  • Tumor heterogeneity and the lactate shuttle in cancer
  • Cell death and pH
  • Clinical implications of the acid-base regulation in cancer
  • Glioblastoma as an ideal test of concept
  • pH evolution in cancer: Its relation with cellular metabolism
  • Conclusions Part 2
  • References
  • Chapter 4: Lactic acid and its transport system
  • Introduction
  • Pro-tumoral activities of lactic acid
  • Lactate contributes to extracellular space (ECS) acidity
  • Lactate is a source of energy for OXPHOS cells: The lactate shuttle
  • Lactate shuttle and pH
  • Clinical implications of the lactate shuttle
  • Lactate enhances tumor cell motility and migration

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