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|2 23
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|a Koltai, Tomas.
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|a An innovative approach to understanding and treating cancer :
|b targeting pH - from etiopathogenesis to new therapeutic avenues /
|c Tomas Koltai, Stephan J. Reshkin, Salvador Harguindey.
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|a London :
|b Academic Press,
|c 2020.
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|a 1 online resource (576 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
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|a Print version record.
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|a Intro -- An Innovative Approach to Understanding and Treating Cancer: Targeting pH: From Etiopathogenesis to New Therapeutic Avenues -- Copyright -- Contents -- Contributors -- Preface -- Part I: Metabolism and pH physiopathology of cancer -- Chapter 1: Introduction -- Introductory words -- The basics -- The importance of pH in cancer -- The evolving concept of pH in cancer -- First phase -- Second phase -- Third phase -- Fourth phase -- Clinical implications -- The objectives of this book -- References -- Chapter 2: Cancer metabolism -- Introduction -- The Warburg effect
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|a The glycolytic phenotype -- Targeting glycolytic enzymes in cancer -- The lactate shuttle122 -- The pentose phosphate pathway -- The lipogenic phenotype -- Fatty acid synthase -- The metabolism of invadopodia -- Glutaminolytic phenotype -- Serine phenotype -- The acid-base balance in malignant tumors -- The ROS problem -- The pH paradigm and metabolic changes in cancer -- Multitargeted attack on tumor metabolism -- Conclusions -- References -- Chapter 3: The pH-centered paradigm in cancer -- Part I: The pH paradigm in cancer. Introduction
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|a Common view points or perceptions of cancer origin and progression -- The pH paradigm in cancer: Extracellular acidity, intracellular alkalinity and the pH gradient -- Effects of pH gradient inversion in cancer -- Intracellular alkalinity -- Extracellular acidity -- The pH gradient inversion -- The hypoxia-pH gradient inversion relationship -- Can hypoxia act as a carcinogenic agent by itself independently of genetic instability? -- Hypoxia and pH gradient inversion -- Clinical impact of the pH centered paradigm in cancer therapeutics
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|a Some examples of how increasing pHe improves therapeutic results -- Conclusions Part I -- Part II: Why and how does the pH-centered paradigm develop in cancer? -- The role of hypoxia in cancer metabolism and growth -- Metabolic switch and pH abnormalities -- Mechanisms that create an acidic extracellular matrix and an alkaline intracellular milieu -- New therapeutic directions derived from the pH-centered paradigm -- Why is pHe so acid and pHi alkaline in cancer cells? -- Tumor heterogeneity and the lactate shuttle in cancer -- Cell death and pH
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|a Clinical implications of the acid-base regulation in cancer -- Glioblastoma as an ideal test of concept -- pH evolution in cancer: Its relation with cellular metabolism -- Conclusions Part 2 -- References -- Chapter 4: Lactic acid and its transport system -- Introduction -- Pro-tumoral activities of lactic acid -- Lactate contributes to extracellular space (ECS) acidity -- Lactate is a source of energy for OXPHOS cells: The lactate shuttle -- Lactate shuttle and pH -- Clinical implications of the lactate shuttle -- Lactate enhances tumor cell motility and migration
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| 500 |
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|a Lactate is a signaling molecule
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| 500 |
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|a Includes index.
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| 650 |
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|a Cancer
|x Treatment
|x Technological innovations.
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| 650 |
1 |
2 |
|a Neoplasms
|x therapy
|0 (DNLM)D009369Q000628
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| 650 |
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|a Cancer
|x Treatment
|x Technological innovations
|2 fast
|0 (OCoLC)fst00845556
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| 700 |
1 |
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|a Reshkin, Stephan J.
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| 700 |
1 |
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|a Harguindey, Salvador.
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| 776 |
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|i Print version:
|a Koltai, Tomas.
|t An Innovative Approach to Understanding and Treating Cancer : Targeting pH - From Etiopathogenesis to New Therapeutic Avenues.
|d San Diego : Elsevier Science & Technology, �2020
|z 9780128190593
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| 856 |
4 |
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|u https://sciencedirect.uam.elogim.com/science/book/9780128190593
|z Texto completo
|
