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|a QP551
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|a 572/.633
|2 23
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|a Advances in protein chemistry and structural biology.
|n volume 118,
|p Protein misfolding /
|c edited by Rossen Donev.
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| 246 |
3 |
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|a Protein misfolding
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| 250 |
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|a First edition.
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| 264 |
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1 |
|a London ;
|a San Diego :
|b Academic Press,
|c 2020.
|
| 264 |
|
4 |
|c �2020
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| 300 |
|
|
|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
|
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Advances in protein chemistry and structural biology ;
|v volume 118
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| 505 |
0 |
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|a Front Cover -- Protein Misfolding -- Protein Misfolding -- Copyright -- Contents -- Contributors -- One -- Theoretical and computational advances in protein misfolding -- 1. Introduction -- 2. Mechanism of protein misfolding -- 3. Simulations: atomistic and coarse grained models -- 4. Atomistic simulations of early-stages monomers, small oligomers and end products of aggregation -- 5. Coarse grained models -- 6. Conclusions -- Acknowledgments -- References -- Two -- Combining molecular dynamics simulations and experimental analyses in protein misfolding -- 1. Introduction
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| 505 |
8 |
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|a 2. Basic concepts of protein misfolding and aggregation -- 3. Biophysical analyses of protein misfolding -- 3.1 X-ray diffraction and small-angle X-ray scattering -- 3.2 Nuclear magnetic resonance analyses -- 3.3 Transmission electron microscopy and cryomicroscopy -- 3.4 Atomic force microscopy -- 3.5 Optical characterization -- 3.6 Mass-spectrometry -- 4. Molecular simulations of misfolding proteins -- 4.1 Atomistic modeling of proteins -- 4.2 Force fields for protein and water models -- 4.3 The challenges of system size and simulation time, and alternative approaches
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| 505 |
8 |
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|a 4.4 Analysis of molecular dynamics trajectories -- 5. Integrative approaches in understanding misfolding and aggregation -- 5.1 Effects of mutations, truncations and insertions on protein structure and stability -- 5.2 Intermediate states, oligomers, and molecular basis of aggregation -- 5.3 Influence of extrinsic factors -- 6. Open questions and challenges -- Acknowledgments -- References -- Three -- Mass spectrometric approaches for profiling protein folding and stability -- 1. Introduction -- 2. Terminology -- 3. Quantitation in mass spectrometry -- 3.1 Spectral counts
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| 505 |
8 |
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|a 3.2 Label free quantification -- 3.3 Targeted proteomics -- 3.4 Stable isotopes -- 3.5 Isobaric tags -- 4. Fractionation methods for characterizing the destabilized proteome -- 4.1 Thermal destabilization -- 4.2 Isolation of aggresomes -- 4.3 Conformational antibodies -- 5. Enzymatic methods for identifying protein stability -- 5.1 Limited proteolysis -- 5.2 Ubiquitinylation -- 6. Exploiting chemical reactivity to characterize protein stability -- 6.1 Hydrogen-deuterium exchange -- 6.2 FPOP -- 6.3 SPROX -- 6.4 Electrophilic profiling -- 6.5 Crosslinking and mass spectrometry (XL-MS) -- 7. Summary
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| 588 |
0 |
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|a Online resource; title from digital title page (viewed on July 20, 2020).
|
| 650 |
|
0 |
|a Protein folding.
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| 650 |
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2 |
|a Protein Folding
|0 (DNLM)D017510
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| 650 |
|
6 |
|a Prot�eines
|x Repliement.
|0 (CaQQLa)201-0217303
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| 650 |
|
7 |
|a Protein folding
|2 fast
|0 (OCoLC)fst01079687
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| 700 |
1 |
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|a Donev, Rossen,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Protein misfolding.
|d [Place of publication not identified] : Academic Press, 2020
|z 0128177500
|z 9780128177501
|w (OCoLC)1108532687
|
| 830 |
|
0 |
|a Advances in protein chemistry and structural biology ;
|v v. 118.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/18761623/118
|z Texto completo
|
