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Human papillomavirus : proving and using a viral cause for cancer /

"[This book] presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal comm...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Jenkins, David (Emeritus professor of pathology), Bosch, F. Xavier
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [Place of publication not identified] : Academic Press, 2020.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Human papillomavirus :  |b proving and using a viral cause for cancer /  |c [edited by] David Jenkins, F. Xavier Bosch. 
260 |a [Place of publication not identified] :  |b Academic Press,  |c 2020. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
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505 0 |a <P><b>Section 1: Early questions and their slow answers </b>1. Introduction: Implications and responses to a possible specific infectious cause for a solid cancer, approaches to proving the role of HPV, and exploring its potential uses against conventional medical practice 2. Cervical and other cancers now associated with HPV prior to recognition of HPV in cervical cancer 3. Cervical screening and its basis in ideas of precancer in classical microscopic pathology 4. The "discovery" of HPV I6 in cervical cancer and studies of its transforming role, P53 and pRB 5. Growing numbers of carcinogenic papillomaviruses and understanding of their differences 6. The impact of HPV on conventional morphological pathology of cancer and precancer. Bethesda classification, molecular markers relating morphology to molecular mechanisms 7. The proof of causality in humans 8. Progression from infection to cancer 9. Sexuality and HPV: sexual transmission, male role 10. Genital warts 11. HPV and non-cervical cancer 12. Immune responses, and antibodies to HPV, making viral antigens 13. Developing and standardising HPV tests 14. HPV and non-HPV pathways to cancer</p> <p><b>Section 2: Prevention of cancer and HPV infection </b>15. Introduction: Evidence-based medicine, HPV and cancer prevention 16. Triage of women with low-grade smear abnormalities and HPV testing, HC1 and 2, GP5+/6+, ALTS trial, Netherlands, other trials 17. Primary screening by HPV testing 18. Prophylactic vaccines, proving their value and the role and limitations of the pharmaceutical industry and its regulators, safety and efficacy 19. Modelling disease, prevention and cost-effectiveness -- a developing process, different types of models, what does cost-effectiveness mean? 20. Changing global concerns about screening and vaccination</p> 
520 |a "[This book] presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal commitment to proving or disproving an idea that aroused initial skepticism, and that still has difficult implications for some. It remains one of the big successes of medicine that exploited both established medical science dating back to the nineteenth century and new molecular genetic science during a time of transition in medicine."--Website ebook 
650 0 |a Papillomaviruses. 
650 0 |a Cancer  |x Etiology. 
650 0 |a Cancer  |x Prevention. 
650 0 |a Virology. 
650 0 |a Papillomavirus diseases. 
650 1 2 |a Papillomavirus Infections  |0 (DNLM)D030361 
650 2 2 |a Papillomaviridae  |x pathogenicity  |0 (DNLM)D027383Q000472 
650 2 |a Papillomaviridae  |0 (DNLM)D027383 
650 2 |a Virology  |0 (DNLM)D014773 
650 6 |a Papillomavirus.  |0 (CaQQLa)201-0150830 
650 6 |a Cancer  |x &#xFFFD;Etiologie.  |0 (CaQQLa)201-0093149 
650 6 |a Cancer  |x Pr&#xFFFD;evention.  |0 (CaQQLa)201-0032223 
650 6 |a Virologie.  |0 (CaQQLa)201-0008933 
650 6 |a Maladies &#xFFFD;a papillomavirus.  |0 (CaQQLa)201-0107022 
650 7 |a Papillomavirus diseases  |2 fast  |0 (OCoLC)fst01052723 
650 7 |a Cancer  |x Etiology  |2 fast  |0 (OCoLC)fst00845361 
650 7 |a Cancer  |x Prevention  |2 fast  |0 (OCoLC)fst00845452 
650 7 |a Papillomaviruses  |2 fast  |0 (OCoLC)fst01052726 
650 7 |a Virology  |2 fast  |0 (OCoLC)fst01167670 
700 1 |a Jenkins, David  |c (Emeritus professor of pathology) 
700 1 |a Bosch, F. Xavier. 
776 0 8 |i Print version:  |z 9780128144862 
776 0 8 |i Print version:  |t Human papillomavirus.  |d [Place of publication not identified] : Academic Press, 2019  |z 0128144572  |z 9780128144572  |w (OCoLC)1082175095 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780128144572  |z Texto completo