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|a (OCoLC)1125919804
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|a 571.64
|2 23
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|a Piezo channels /
|c edited by Philip A. Gottlieb.
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|a Cambridge, Massachusetts :
|b Academic Press,
|c 2017.
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|c �2017
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| 300 |
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|a 1 online resource (350 pages) :
|b illustrations.
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| 336 |
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|a text
|2 rdacontent
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| 337 |
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|a computer
|2 rdamedia
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|a online resource
|2 rdacarrier
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|a Current Topics in Membranes ;
|v Volume 79
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| 504 |
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|a Includes bibliographical references at the end of each chapters.
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|a Description based on online resource; title from PDF title page (ebrary, viewed August 14, 2017).
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|a Front Cover; Piezo Channels; CURRENT TOPICS IN MEMBRANES, VOLUME 79; Piezo Channels; Contents; CONTRIBUTORS; PREFACE; One -- A Tour de Force: The Discovery, Properties, and Function of Piezo Channels; 1. BACKGROUND; 2. DISCOVERY OF PIEZO CHANNELS; 2.1 Identification of Piezo genes; 2.1.1 Neuro2A cell line produces mechanical current; 2.1.2 Identification of Piezo1 (FAM38a); 2.1.3 Piezo1 in the plasma membrane; 2.1.4 Heterologous expression; 2.1.5 Inhibitors of Piezo channels; 2.1.5.1 Small molecule; 2.1.5.2 Peptide; 2.1.5.3 Protein; 2.1.6 Distribution of Piezo1 and Piezo2
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|a 2.1.7 Bilayer reconstitution of Piezo12.2 Piezo1 functional stoichiometry; 2.3 Biophysical properties of mouse Piezo1; 2.3.1 Mouse Piezo1 inactivation; 2.3.2 Piezo channel clusters; 2.3.3 Effects of modulating the cytoskeleton; 2.3.4 Protonation of PIEZO1; 2.3.5 Diseases of piezo mechanical channels; 2.4 Chemical activation of Piezo1; 2.5 Cytoskeleton modulates Piezo1 function; 2.5.1 Tuning Piezo1 activity; 2.5.2 Filamin-A modulates Piezo1 function; 2.6 Cell motility and Piezo1; 2.6.1 Integrin activation and Piezo1 (Fam38a); 2.6.2 Breast cancer; 2.6.3 Prostate cancer
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|a 2.7 Piezo1's role in cell contact2.7.1 Lineage choice in neural stem cells; 2.7.2 Neuron-astrocyte interaction; 2.7.3 Cell homeostasis; 2.8 Functional role of Piezo; 2.8.1 Nociception of Drosophila larvae; 2.8.2 Shear stress response of Piezo1; 2.8.3 Calcium influx and ATP release; 2.8.4 Piezo2 and light touch; 2.8.4.1 Optogenetic approach; 2.8.4.2 Knockout approach; 2.8.4.3 Biochemical and knockdown approach; 2.9 Piezo2 channels in other roles; 2.9.1 Piezo2 in foraging duck; 2.9.2 Piezo2 in proprioception; 2.9.3 Piezo2 channels in the gut; 2.9.4 Piezo2 and pain; 3. CONCLUSION; ACKNOWLEDGMENT
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|a 4.6 Challenges for the Piezo1 sensor hypothesis4.7 How might activation of Piezo1 channels lead to vascular remodeling?; 4.8 Mutations in human PIEZO1 gene; 4.9 Relationships of Piezo1 to other candidate shear stress sensors; 5. CONCLUSIONS AND FUTURE DIRECTIONS; ACKNOWLEDGMENTS; REFERENCES; Three -- Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels; 1. INTRODUCTION; 2. ORIGIN OF THE "FORCE-FROM-LIPIDS PRINCIPLE"; 2.1 Evolutionary origins of mechanosensitive channels; 2.2 Evolutionary timeline of MS channels; 2.3 Piezo evolution
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|a Legal Deposit;
|c Only available on premises controlled by the deposit library and to one user at any one time;
|e The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
|5 WlAbNL
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|a Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.
|5 WlAbNL
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|a Text in English.
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| 650 |
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|a Ion channels.
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1 |
2 |
|a Ion Channels
|x physiology
|0 (DNLM)D007473Q000502
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| 650 |
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|a Ion Channels
|0 (DNLM)D007473
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| 650 |
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|a Canaux ioniques.
|0 (CaQQLa)201-0145111
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| 650 |
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|a SCIENCE
|x Life Sciences
|x Anatomy & Physiology.
|2 bisacsh
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| 650 |
|
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|a Ion channels
|2 fast
|0 (OCoLC)fst00978573
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| 700 |
1 |
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|a Gottlieb, Philip A.,
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|t Piezo Channels.
|d Cambridge, MA : Elsevier/Academic Press, 2017
|z 9780128093894
|z 0128093897
|w (OCoLC)974699204
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| 830 |
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0 |
|a Current topics in membranes ;
|v Volume 79.
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| 856 |
4 |
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|u https://sciencedirect.uam.elogim.com/science/bookseries/10635823/79
|z Texto completo
|
