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Improving the therapeutic ratio in head and neck cancer /
Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a road...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom ; Cambridge, MA :
Academic Press, an imprint of Elsevier,
[2020]
|
| Edición: | First edition. |
| Colección: | Cancer sensitizing agents for chemotherapy ;
v. 6. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 003 | OCoLC | ||
| 005 | 20231120010416.0 | ||
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| 007 | cr cnu---unuuu | ||
| 008 | 191109s2020 enk ob 001 0 eng d | ||
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| 020 | |a 9780128178690 |q (electronic book) | ||
| 020 | |a 0128178698 |q (electronic book) | ||
| 020 | |z 9780128178683 | ||
| 035 | |a (OCoLC)1124608942 | ||
| 050 | 4 | |a RC271.D52 |b R65 2020 | |
| 050 | 4 | |a RC280.H4 | |
| 082 | 0 | 4 | |a 616.9940654 |2 23 |
| 082 | 0 | 4 | |a 616.99491 |2 23 |
| 245 | 0 | 0 | |a Improving the therapeutic ratio in head and neck cancer / |c volume editor, Randall J. Kimple. |
| 250 | |a First edition. | ||
| 264 | 1 | |a London, United Kingdom ; |a Cambridge, MA : |b Academic Press, an imprint of Elsevier, |c [2020] | |
| 300 | |a 1 online resource (378 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Cancer sensitizing agents for chemotherapy ; |v volume 6 | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover; Improving the Therapeutic Ratio in Head and Neck Cancer; Copyright; Aims and Scope for Series ""Cancer Sensitizing Agents for Chemotherapy; About the Series Editor; About the Editor; Aims and Scope for ""Improving the Therapeutic Ratio in Head and Neck Cancer; Preface; Contents; Contributors; Chapter 1: Overview of head and neck cancer management; Introduction; Anatomy; Clinical evaluation; Oropharynx; Epidemiology; Pathology; Anatomy and staging; General treatment approach; Initial surgery; Initial radiation-based therapy; Key clinical research themes; Nasopharynx; Epidemiology | |
| 505 | 8 | |a PathologyAnatomy and staging; General treatment approach; Key clinical research themes; Oral cavity; Epidemiology and pathology; Anatomy and staging; General treatment approach; Key clinical research themes; Larynx and hypopharynx; Epidemiology and staging; General treatment approach; Key clinical research themes; Salivary gland tumors; Epidemiology and pathology; Anatomy and staging; General treatment approach and key clinical research themes; Recurrent and metastatic squamous cell carcinoma of the head and neck; Conclusion; References | |
| 505 | 8 | |a Chapter 2: The role of molecularly targeted therapies and immunotherapy in head and neck cancerCurrent therapies for recurrent/metastatic disease; Early work with cytotoxic agents; Emergence of targeted therapy against the epidermal growth factor receptor (EGFR); Cetuximab plus chemotherapy in the first line metastatic setting; Panitumumab as an alternative targeted agent for HNSCC; Practical approach to first line systemic treatment; Dawn of an immunotherapy trend; Pembrolizumab; Nivolumab; Durvalumab; Ongoing trials and future directions; Future directions; Acknowledgments; References | |
| 505 | 8 | |a Chapter 3: Combining radiation and chemotherapy to improve the therapeutic ratioBasic principles of radiobiology; Basic principles of radiation-induced cell death; Basic principles of radiotherapy in head and neck cancer management; Basic principles of toxicities of head and neck cancer management; Widening the therapeutic window; Radiotherapy dose/volume reduction in the absence of a surgical component or induction chemotherapy; Radiotherapy dose/volume reduction following induction chemotherapy; Systemic therapy toxicity studies without radiotherapy or surgical components | |
| 505 | 8 | |a Radiotherapy dose/volume reductions with a surgical componentRadiotherapy protectors; Proton therapy; Conclusion; Acknowledgments; References; Chapter 4: Targeting TP53 to augment therapeutic response in head and neck cancer; Introduction; Current treatment for head and neck squamous cell carcinoma (HNSCC); Mutations in TP53 are common deleterious genetic alterations in HNSCC; Tumor suppressive functions of TP53; TP53 mutations as a prognostic and predictive biomarker for poor outcomes in HNSCC; TP53 gene transfer therapy for HNSCC | |
| 500 | |a Restoration of wild-type p53 confirmation and function in HNSCC as a novel therapeutic approach | ||
| 588 | 0 | |a Online resource; title from digital title page (viewed on November 27, 2019). | |
| 520 | |a Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. | ||
| 650 | 0 | |a Cancer |x Chemotherapy. | |
| 650 | 0 | |a Head |x Cancer |x Treatment. | |
| 650 | 0 | |a Neck |x Cancer |x Treatment. | |
| 650 | 1 | 2 | |a Head and Neck Neoplasms |x drug therapy |0 (DNLM)D006258Q000188 |
| 650 | 1 | 2 | |a Head and Neck Neoplasms |x radiotherapy |0 (DNLM)D006258Q000532 |
| 650 | 6 | |a Cancer |x Chimioth�erapie. |0 (CaQQLa)201-0004691 | |
| 650 | 7 | |a Cancer |x Chemotherapy. |2 fast |0 (OCoLC)fst00845327 | |
| 650 | 7 | |a Head |x Cancer |x Treatment. |2 fast |0 (OCoLC)fst00952589 | |
| 650 | 7 | |a Neck |x Cancer |x Treatment. |2 fast |0 (OCoLC)fst01035351 | |
| 655 | 4 | |a Internet Resources. | |
| 700 | 1 | |a Kimple, Randall J. | |
| 776 | 0 | 8 | |i Print version: |a Kimple, Randall J. |t Improving the Therapeutic Ratio in Head and Neck Cancer. |d San Diego : Elsevier Science & Technology, �2019 |z 9780128178683 |
| 830 | 0 | |a Cancer sensitizing agents for chemotherapy ; |v v. 6. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128178683 |z Texto completo |