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|a 1129800019
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|a 0128137630
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|a 9780128137635
|q (electronic bk.)
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|z 9780128137628
|q (pbk.)
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|z 0128137622
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|a (OCoLC)1120695816
|z (OCoLC)1129800019
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|a RC815
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|a 616.310072
|2 23
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|a Translational systems medicine and oral disease /
|c edited by Stephen T. Sonis, Alessandro Villa.
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|a London :
|b Academic Press, an imprint of Elsevier,
|c [2020]
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| 300 |
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|a 1 online resource (xvii, 439 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Print version record.
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0 |
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|a Front Cover; Translational Systems Medicine and Oral Disease; Translational Systems Medicine and Oral Disease; Copyright; Contents; List of contributors; Preface; 1 -- Introduction to systems medicine; Reductionism; Systems biology and medicine; Systems medicine and oral disease; 2 -- System biology; Introduction to system biology; Cell biology and networks; Signaling networks; Metabolic networks; Regulatory networks; Omics data; Practical implications; References; 3 -- Genomic foundation for medical and oral disease translation to clinical assessment; Introduction
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| 505 |
8 |
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|a The basics of the genomic systemGene code; Non-B DNA; A-motif; I-motif; DNA hairpins; H-DNA; B-DNA; Nucleic acid hybridization; tRNA coding; Pseudogene function; tRNA functionality; Conversion of B DNA into non-B DNA; Helical variations of B-DNA; A-DNA; Z-DNA; Gene coding and noncoding; Histones-chromatin-nucleosomes; Ploidy-aneuploidy; Somatic mutation; Mutation manipulation of genome expression; SNPs; Haplotype genotype variation; Allelic variability; RNAs: other useful functions in genomic expression; miRNA; siRNA; Small activating RNAs; PIWI-interacting RNAs; Small nuclear RNA/U-RNA
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| 505 |
8 |
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|a Extracellular RNALong noncoding RNAs; SWI/SNF complex; Circular RNA; X-inactive-specific transcript; HOTAIR (HOX (homeobox gene; transcript antisense RNA)); Telomerase RNA component; Y RNA; Cis-natural antisense transcript; Alternate splicing; Transcribed ultraconserved regions; Darwinism influence on genomic expression and risk for disease; Biologic fitness; Factors characterize degeneracy: complexity, evolvability, and robustness; Causality ("cause and effect"); Genetic drift; Why human genetics is difficult to model?; Present status of genomic analysis and determination of disease risk
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| 505 |
8 |
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|a GenomicsRoad to personalized medicine; References; 4 -- Proteomics; Introduction; Whole saliva; Definition of proteomics; Salivary proteomics; Proteomic technologies; Mass spectrometry; Emerging MS-based approaches; Selected reaction monitoring-based targeted proteomics; Large-scale targeted proteomics (SWATH); Metaproteomics; The human whole saliva proteomic technologies; Clinical applications of salivary proteomics; Periodontitis and dental caries; Orthodontically induced inflammatory root resorption; Primary S�jgren's Syndrome; Oral squamous cell carcinoma; Gastric cancer; Lung cancer
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| 505 |
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|a Breast cancerOvarian cancer; Oral chronic graft-versus-host-disease; Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome; Human immunodeficiency virus; Conclusions; Acknowledgments; References; 5 -- Metabolomics in head and neck cancer: A summary of findings; Introduction; Saliva metabolomics; Blood and urine metabolomics; Cell and tissue metabolomics; Conclusions and future perspectives; Abbreviations; Acknowledgments; Conflict of Interest Statement; References; 6 -- Microbiomics; The human microbiome: a general overview; Background and definitions; The many microbiomes
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| 650 |
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0 |
|a Oral medicine.
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| 650 |
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0 |
|a Mouth
|x Diseases.
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| 650 |
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2 |
|a Oral Medicine
|0 (DNLM)D019242
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| 650 |
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2 |
|a Mouth Diseases
|0 (DNLM)D009059
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| 650 |
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6 |
|a Stomatologie.
|0 (CaQQLa)201-0034317
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| 650 |
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6 |
|a Bouche
|x Maladies.
|0 (CaQQLa)201-0008587
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| 650 |
|
7 |
|a Mouth
|x Diseases
|2 fast
|0 (OCoLC)fst01028442
|
| 650 |
|
7 |
|a Oral medicine
|2 fast
|0 (OCoLC)fst01047088
|
| 700 |
1 |
|
|a Sonis, Stephen T.,
|e editor.
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| 700 |
1 |
|
|a Villa, Alessandro,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|a Sonis, Stephen.
|t Translational Systems Medicine and Oral Disease.
|d San Diego : Elsevier Science & Technology, �2019
|z 9780128137628
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128137628
|z Texto completo
|
