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|a 615.1
|2 23
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| 100 |
1 |
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|a Lai, Wing-Fu.
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| 245 |
1 |
0 |
|a Delivery of therapeutics for biogerontological interventions :
|b from concepts to experimental design /
|c Wing-Fu Lai.
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| 260 |
|
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|a London :
|b Academic Press,
|c 2019.
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| 300 |
|
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|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 588 |
0 |
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|a Print version record.
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| 505 |
0 |
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|a Front Cover; Delivery of Therapeutics for Biogerontological Interventions; Copyright Page; Contents; Foreword; Preface; Abbreviations; I. From Concepts to Plans; 1 Theoretical frameworks for intervention development; Introduction; A reductionist approach to understand aging; Reliability theory of aging; Hypothetical frameworks for tackling aging; Reasons for the failure of an intervention; Summary; References; 2 Available delivery technologies for intervention execution; Introduction; Use of delivery technologies in interventions; Advances in delivery of nucleic acids
|
| 505 |
8 |
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|a Nucleic acid delivery mediated by biological meansNucleic acid delivery mediated by chemical and physical means; Advances in delivery of nongenetic materials; Integration of engineering techniques into therapeutics delivery; Summary; References; II. From Plans to Technologies; 3 Design of viral vectors for genetic manipulation; Introduction; Engineering the properties of a viral vector; Chemical manipulation for controlled delivery; Applications in genetic manipulation; Opportunities and challenges; Summary; References; 4 Design of polymeric vectors for genetic manipulation; Introduction
|
| 505 |
8 |
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|a Selection of polymeric vectorsStructural modification of polymeric vectors; Copolymerization; Functional group modification; Ligand conjugation; Optimization for intervention execution; Summary; References; 5 Design of cyclodextrin-based systems for intervention execution; Introduction; Basic properties of cyclodextrins; Strategies for structural engineering of cyclodextrins; Roles in vector design; Cyclodextrin incorporation for multifunctionality; Manipulation of host-guest complexation; Summary; References; 6 Design of upconversion nanoparticles for intervention execution; Introduction
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| 505 |
8 |
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|a Major designing principlesFabrication and morphological manipulation of upconversion nanoparticles; Generation of upconversion nanoparticle-based nucleic acid carriers; Roles of upconversion nanoparticles in nucleic acid delivery; Light-mediated control of intervention execution; Imaging and tracking of the delivery process; Optimization of upconversion nanoparticle-based nucleic acid carriers; Improvement in upconversion nanoparticle fabrication; Summary; References; 7 Design of hydrogel-based nanoparticles for intervention execution; Introduction; Development of hydrogels for drug delivery
|
| 505 |
8 |
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|a Design of hydrogels for intervention developmentGeneration of hydrogel nanoparticles; Ring-opening polymerization; Aqueous dispersion polymerization; Emulsion polymerization; Methods for drug loading; Strategies for cargo loading; Factors influencing the loading efficiency; Modulation of drug release; Summary; References; III. From Technologies to Interventions; 8 Use of delivery technologies to mediate RNA degradation; Introduction; Manipulation of the aging network by RNAi; Enhancement of the siRNA performance; Delivery of siRNA therapeutics; Clinical use of siRNA therapeutics
|
| 504 |
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|a Includes bibliographical references and index.
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| 650 |
|
0 |
|a Geriatric pharmacology.
|
| 650 |
|
0 |
|a Drug delivery systems.
|
| 650 |
|
0 |
|a Life expectancy.
|
| 650 |
1 |
2 |
|a Drug Delivery Systems
|0 (DNLM)D016503
|
| 650 |
2 |
2 |
|a Aging
|x physiology
|0 (DNLM)D000375Q000502
|
| 650 |
2 |
2 |
|a Life Expectancy
|0 (DNLM)D008017
|
| 650 |
2 |
2 |
|a Geriatrics
|x methods
|0 (DNLM)D005853Q000379
|
| 650 |
|
6 |
|a Pharmacologie g�eriatrique.
|0 (CaQQLa)201-0022818
|
| 650 |
|
6 |
|a Syst�emes d'administration de m�edicaments.
|0 (CaQQLa)000260397
|
| 650 |
|
6 |
|a Esp�erance de vie.
|0 (CaQQLa)201-0041958
|
| 650 |
|
7 |
|a Life expectancy
|2 fast
|0 (OCoLC)fst00998268
|
| 650 |
|
7 |
|a Drug delivery systems
|2 fast
|0 (OCoLC)fst00898667
|
| 650 |
|
7 |
|a Geriatric pharmacology
|2 fast
|0 (OCoLC)fst00941246
|
| 776 |
0 |
8 |
|i Print version:
|z 0128164859
|z 9780128164853
|w (OCoLC)1089004236
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128164853
|z Texto completo
|
