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Pharmacoepigenetics /
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press, an imprint of Elsevier,
[2019]
|
| Edición: | First edition. |
| Colección: | Translational epigenetics series ;
v. 10. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Pharmacoepigenetics; Copyright; Contents; Contributors; Pharmacoepigenetics: A Long Way Ahead; Chapter 1: The Epigenetic Machinery in the Life Cycle and Pharmacoepigenetics; 1.1. Introduction; 1.2. The Epigenetic Machinery; 1.2.1. DNA Methylation; 1.2.2. DNA Demethylation; 1.2.2.1. Ten-Eleven Translocation (TET) Proteins; 1.2.2.2. AID/APOBEC Family Cytidine Deaminases; 1.2.2.3. BER (Base Excision Repair) Glycosylases; 1.2.3. Chromatin Remodeling and Histone Modifications; 1.2.3.1. Chromatin; 1.2.3.1.1. Genome-Wide Chromatin Conformation, Spatial Organization, and 3D Genomics
- 1.2.3.2. Histones1.2.3.3. Posttranslational Modifications; 1.2.3.3.1. Histone Methylation-Demethylation; 1.2.3.3.2. Histone Acetylation; 1.2.3.3.3. Histone Deacetylation; Sirtuins; 1.2.3.3.4. Histone Acylation; 1.2.3.3.5. Histone Propionylation; 1.2.3.3.6. N-Glycosylation and O-GlcNAcylation; 1.2.3.3.7. Ubiquitination-Deubiquitination; 1.2.3.3.8. SUMOylation; 1.2.3.3.9. Histone Phosphorylation-Dephosphorylation; 1.2.3.3.10. Histone Chaperonization; 1.2.3.3.11. Glutathionylation; 1.2.3.3.12. Poly ADP-Ribosylation; 1.2.3.3.13. Oxidative Stress; 1.2.3.4. Other Posttranslational Changes
- 1.2.3.5. Noncoding RNAs1.2.3.5.1. miRNAs; 1.2.3.5.2. circRNAs; 1.2.3.5.3. RNA Methylation; 1.2.3.6. Other Operational Elements of the Epigenetic Machinery; 1.2.3.6.1. DNA Replication Regulators; 1.2.3.6.2. N6-Adenine DNA Methylation; 1.2.3.6.3. Transcription Factors; 1.2.3.6.4. Transcriptional Repression; 1.2.3.6.5. Polycomb Group Proteins: Polycomb Repressive Complex 2 (PRC2); 1.2.3.6.6. BET (Bromodomain and Extraterminal Domain) Proteins; 1.2.3.6.7. UHRF1; 1.2.3.6.8. Plant Homeodomain (PHD) Fingers; 1.2.3.6.9. HDACs; 1.2.3.6.10. Chromatin-Remodeling Factors
- 1.2.3.6.11. Heterochromatin and Gene Silencing1.2.3.6.12. MEN1; 1.2.3.6.13. NPC, HOXA, and Nup93; 1.2.3.6.14. CCR4; 1.2.3.6.15. HP1; 1.2.3.6.16. TORC1; 1.2.3.6.17. WDR5; 1.2.3.6.18. Nudt21; 1.2.3.6.19. Trithorax-Group Proteins; 1.2.3.6.20. SUUR Protein; 1.2.3.6.21. Kap123; 1.2.3.6.22. SET Complex; 1.2.3.6.23. Histone Code Reader Spin1; 1.2.3.6.24. Proteasome; 1.2.3.6.25. Lipid Mediators; 1.2.3.6.26. Transposable Elements; 1.2.3.6.27. Intragenic Enhancers; 1.2.3.6.28. Genomic Regulatory Regions; 1.3. Singular Epigenetic Phenomena; 1.3.1. Aneuploidy; 1.3.2. X Chromosome Inactivation
- 1.3.3. Meiotic Silencing1.3.4. RNA Splicing; 1.3.5. Copy Number Variation (CNV); 1.3.6. The Epigenetic Clock; 1.3.7. Epigenetic Reprogramming Memory; 1.3.8. Transgenerational Epigenetic Inheritance; 1.3.9. DNA Repair Pathways and Genomic Instability; 1.3.10. Antibody Maturation; 1.3.11. Sexual Dimorphism; 1.3.12. Heritable RNAi; 1.3.13. Genomic Imprinting; 1.4. Evolution; 1.5. Population Epigenetics; 1.6. Fertility and Gestation; 1.6.1. In Vitro Fertilization and Assisted Reproduction Technology; 1.7. Placenta; 1.8. Lactation; 1.9. Development; 1.10. Maturation, Aging, and Longevity