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190529t20192019enk ob 001 0 eng d |
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|a 1102804516
|a 1229425118
|a 1235833002
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|a 9780128137970
|q (electronic bk.)
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|a 0128137975
|q (electronic bk.)
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|z 9780128137963
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|z 0128137967
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|a (OCoLC)1102638944
|z (OCoLC)1102804516
|z (OCoLC)1229425118
|z (OCoLC)1235833002
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|2 23
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| 245 |
0 |
0 |
|a Chromatin signaling and neurological disorders /
|c edited by Olivier Binda.
|
| 264 |
|
1 |
|a London :
|b Academic Press,
|c [2019]
|
| 264 |
|
4 |
|c �2019
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| 300 |
|
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|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
|
| 337 |
|
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|a computer
|b c
|2 rdamedia
|
| 338 |
|
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|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Translational epigenetics series ;
|v v. 12
|
| 500 |
|
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|a Includes index.
|
| 588 |
0 |
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|a Online resource; title from PDF title page (EBSCO, viewed June 3, 2019).
|
| 505 |
0 |
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|a Front Cover; Chromatin Signaling and Neurological Disorders; Translational Epigenetics Series; Chromatin Signaling and Neurological Disorders; Copyright; Contents; Contributors; Preface; Chromatin and epigenetics; Chromatin signaling and neurological diseases; References; 1 -- Chromatin and epigenetic signaling pathways; 1.1 Chromatin signaling and epigenetics; 1.2 Chromatin organization; 1.3 Histone posttranslational modifications and the histone code; 1.4 Functions of histone posttranslational modifications; 1.5 DNA methylation; 1.6 Writers, erasers, and readers; 1.6.1 Histone writers
|
| 505 |
8 |
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|a 1.6.2 DNA writers1.6.3 Histone erasers; 1.6.4 DNA erasers; 1.6.5 Histone readers; 1.6.6 DNA readers; 1.7 Modification cross talk; 1.8 Effects of metabolism on histone and DNA modifications; 1.9 Epigenetic inheritance; 1.10 Summary; References; 1 -- Neurodegenerative disorders; 2 -- Into the unknown: chromatin signaling in spinal muscular atrophy; 2.1 Spinal muscular atrophy: prevalence, genetic basis, clinical features, and pathogenesis; 2.2 The survival motor neuron protein: localization, structure, and function; 2.3 Epigenetic landscape in spinal muscular atrophy pathogenesis
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| 505 |
8 |
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|a 2.4 Targeting epigenetic factors as potential therapeutics in spinal muscular atrophy2.4.1 Histone deacetylase inhibitors as regulators of the survival motor neuron gene; 2.4.2 The nonspecific effect of histone deacetylase inhibitors; 2.4.3 The potential protective effect of histone deacetylase inhibitors in the pathogenesis of spinal muscular atrophy; 2.5 Conclusion; Acronyms and abbreviations; Acknowledgments; References; 3 -- Charcot-Marie-Tooth disease; 3.1 Introduction; 3.2 Epigenetic regulation of Schwann cell development; 3.3 Epigenetic regulation of dosage-sensitive genes
|
| 505 |
8 |
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|a 3.4 Epigenetic regulators targeted by CMT mutations3.4.1 DNMT1; 3.4.2 LMNA; 3.4.3 SYNE1; 3.4.4 MED25; 3.4.5 SETX; 3.4.6 MORC2; 3.4.7 PRDM12; 3.5 Novel mechanisms for CMT mutations; 3.6 Summary; Acknowledgments; References; 4 -- Epigenetic mechanisms in Huntington's disease; 4.1 Introduction; 4.2 Huntington's disease; 4.2.1 Neuropathology of HD; 4.3 Transcriptional dysregulation in HD; 4.4 Altered epigenetic marks in HD; 4.4.1 Histone modifications; 4.4.1.1 Histone acetylation; 4.4.1.2 Histone acetylation alterations in HD; 4.4.1.3 Histone methylation; 4.4.1.4 Histone methylation changes in HD
|
| 505 |
8 |
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|a 4.4.1.5 Histone phosphorylation4.4.1.6 Histone phosphorylation and HD; 4.4.1.7 Histone ubiquitination; 4.4.1.8 Altered histone ubiquitination in HD; 4.4.2 DNA methylation; 4.4.3 DNA methylation changes in HD; 4.4.3.1 Global DNA methylation changes; 4.4.3.2 Gene-specific DNA methylation changes; 4.4.3.3 Implicating DNA methylation enzymes; 4.5 Epigenetic-based therapies; 4.5.1 HDAC inhibitors as a treatment for HD; 4.5.2 Methylation-inhibiting drugs; 4.6 Concluding remarks; 4.7 Abbreviations; References; 5 -- The epigenetics of multiple sclerosis
|
| 504 |
|
|
|a Includes bibliographical references and index.
|
| 650 |
|
0 |
|a Chromatin.
|
| 650 |
|
0 |
|a Nervous system
|x Diseases.
|
| 650 |
|
0 |
|a Genetic regulation.
|
| 650 |
1 |
2 |
|a Nervous System Diseases
|x genetics
|0 (DNLM)D009422Q000235
|
| 650 |
1 |
2 |
|a Chromatin
|x metabolism
|0 (DNLM)D002843Q000378
|
| 650 |
2 |
2 |
|a Histones
|x metabolism
|0 (DNLM)D006657Q000378
|
| 650 |
2 |
2 |
|a Signal Transduction
|x genetics
|0 (DNLM)D015398Q000235
|
| 650 |
2 |
2 |
|a Chromatin Assembly and Disassembly
|0 (DNLM)D042002
|
| 650 |
2 |
2 |
|a Gene Expression Regulation
|0 (DNLM)D005786
|
| 650 |
2 |
2 |
|a Epigenesis, Genetic
|0 (DNLM)D044127
|
| 650 |
|
2 |
|a Chromatin
|0 (DNLM)D002843
|
| 650 |
|
2 |
|a Nervous System Diseases
|0 (DNLM)D009422
|
| 650 |
|
6 |
|a Chromatine.
|0 (CaQQLa)201-0062726
|
| 650 |
|
6 |
|a Syst�eme nerveux
|x Maladies.
|0 (CaQQLa)201-0007359
|
| 650 |
|
6 |
|a R�egulation g�en�etique.
|0 (CaQQLa)201-0028678
|
| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Biochemistry.
|2 bisacsh
|
| 650 |
|
7 |
|a Genetic regulation
|2 fast
|0 (OCoLC)fst00940086
|
| 650 |
|
7 |
|a Chromatin
|2 fast
|0 (OCoLC)fst00859922
|
| 650 |
|
7 |
|a Nervous system
|x Diseases
|2 fast
|0 (OCoLC)fst01036098
|
| 655 |
|
4 |
|a Dictionaries.
|
| 655 |
|
4 |
|a Internet Resources.
|
| 700 |
1 |
|
|a Binda, Olivier,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|t Chromatin signaling and neurological disorders.
|d London : Academic Press, [2019]
|z 0128137967
|z 9780128137963
|w (OCoLC)1022787494
|
| 830 |
|
0 |
|a Translational epigenetics series ;
|v v. 12.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128137963
|z Texto completo
|
