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Animal models in cancer drug discovery /

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Azmi, Asfar S. (Editor ), Mohammad, Ramzi M. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, United Kingdom ; Cambridge, MA : Academic Press, [2019]
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Animal models in cancer drug discovery /  |c edited by Asfar Azmi, Ramzi M. Mohammad. 
264 1 |a London, United Kingdom ;  |a Cambridge, MA :  |b Academic Press,  |c [2019] 
300 |a 1 online resource (xx, 450 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
588 |a Online resource; title from PDF title page (EBSCO, viewed April 22, 2019). 
504 |a Includes bibliographical references and index. 
520 |a Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. 
505 0 |a Chapter 1 -- Role of animal research in human malignancies -- Chapter 2 -- Preclinical models in ovarian cancer -- Chapter 3 -- Animal models of cancer-associated cachexia -- Chapter 4 -- Imaging tools to enhance animal tumor models for cancer research and drug discovery -- Chapter 5 -- Protocols in genetic mice models of pancreatic cancer -- Chapter 6 -- Chemo-prevention and interception of obesity-promoted pancreatic ductal adenocarcinoma -- Chapter 7 -- Animal models of primary brain tumors -- Chapter 8 -- Metastatic brain tumor models and drug brain penetration analysis -- Chapter 9 -- A guide to tumor assessment methodologies in cancer drug discovery -- Chapter 10 -- Mouse models of pancreatic cancer: An ever-emerging arm of cancer drug discovery -- Chapter 11 -- Mouse models of gastrointestinal cancers in drug development and research -- Chapter 12 -- Preclinical animal tumor models to study prevention of colon cancer recurrence by curcumin -- Chapter 13 -- Role of 3D tissue engineering models for human cancer and drug development -- Chapter 14 -- Drug development using pancreatic and lung organoid models -- Chapter 15 -- Leveraging dogs with spontaneous cancer to advance drug development -- Chapter 16 -- Cancer imaging in preclinical models -- Chapter 17 -- Animal (mouse) models of melanoma -- Chapter 18 -- Animal mouse models of acute myeloid leukemia 
650 0 |a Cancer  |x Animal models. 
650 0 |a Cancer  |x Chemotherapy  |x Research. 
650 0 |a Pharmacology, Experimental. 
650 0 |a Antineoplastic agents. 
650 0 |a Antimitotic agents. 
650 2 |a Drug Discovery  |0 (DNLM)D055808 
650 2 |a Antineoplastic Agents  |0 (DNLM)D000970 
650 2 |a Models, Animal  |0 (DNLM)D023421 
650 2 |a Antimitotic Agents  |0 (DNLM)D050256 
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650 6 |a Anticanc�ereux.  |0 (CaQQLa)201-0004692 
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650 7 |a Cancer  |x Animal models  |2 fast  |0 (OCoLC)fst00845323 
650 7 |a Cancer  |x Chemotherapy  |x Research  |2 fast  |0 (OCoLC)fst00845335 
650 7 |a Pharmacology, Experimental  |2 fast  |0 (OCoLC)fst01060280 
700 1 |a Azmi, Asfar S.,  |e editor. 
700 1 |a Mohammad, Ramzi M.,  |e editor. 
776 0 8 |i Print version:  |z 0128147040  |z 9780128147047  |w (OCoLC)1057305250 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780128147047  |z Texto completo