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Discovery and development of therapeutics from natural products against neglected tropical diseases /
Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and ident...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2019.
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| Colección: | Natural product drug discovery.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases; Copyright Page; Dedication; Contents; List of Contributors; Editor Biography; Foreword; Preface; 1 Therapeutics from natural products against neglected tropical diseases: an overview; 1.1 Introduction; 1.2 An overview of the book; 1.3 Concluding remarks; 2 Marine natural products as strategic prototypes in the development of a new generation of antimalarial agents; 2.1 Introduction; 2.2 Antimalarial marine natural products; 2.2.1 Phenolic compounds and polyketides
- 2.2.2 Terpenoids2.2.3 Endoperoxides and polyethers; 2.2.4 Alkaloids; 2.2.5 Peptides and depsipeptides; 2.2.6 Phosphotriesters; 2.3 Concluding remarks; List of abbreviations; References; Further reading; 3 Sesquiterpene lactones: a versatile class of structurally diverse natural products and their semisynthetic analogs as pot ... ; 3.1 Introduction; 3.2 Antimalarial potential of plant derived sesquiterpene lactones; 3.2.1 Artemisinin and its C-12 oxa (ether/ester) derivatives; 3.2.1.1 Synthesis of C-12 carba-derivatives of artemisinin
- 3.2.1.2 Synthesis of C-13 substituted derivatives of artemisinin from artemisitene3.2.1.3 Artemisinin dimers, trimers, and tetramers: novel leads in drug discovery; 3.2.1.4 Synthesis of artemisinin dimers; 3.2.1.5 Synthesis of artemisinin trimers and tetramers; 3.2.2 Germacranolides, guaianolides, and pseudoguiainolides antimalarials SLs; 3.2.2.1 Germacranolides; 3.2.2.2 Guaianolides and pseudoguaianolides; 3.2.3 Miscellaneous antimalarial sesquiterpene lactones; 3.3 Structural-activity relationships of sesquiterpene lactones; 3.4 Concluding remarks; Acknowledgments; List of abbreviations
- 4.6 Natural sources of quinoline alkaloids with antiparasitic activity4.7 Synthetic efforts for targeted quinoline compounds; 4.7.1 Synthesis of polyfunctionalized quinolines from unsubstituted anilines: Route A; 4.7.2 Synthesis of polyfunctionalized quinolines from ortho-substituted anilines: Route B; 4.8 Quinoline compounds as antitrypanosomal agents; 4.8.1 Simple polyfunctionalized quinolines; 4.8.2 Polycyclic quinoline molecules; 4.9 Concluding remarks; Acknowledgment; List of abbreviations; References; Further reading