Cargando…
Discovery and development of therapeutics from natural products against neglected tropical diseases /
Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and ident...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2019.
|
| Colección: | Natural product drug discovery.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_on1097248779 | ||
| 003 | OCoLC | ||
| 005 | 20231120010349.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 190416s2019 ne ob 001 0 eng d | ||
| 040 | |a N$T |b eng |e rda |e pn |c N$T |d N$T |d EBLCP |d OPELS |d UKMGB |d OCLCF |d YDX |d UKAHL |d OCLCQ |d S2H |d OCLCO |d VLY |d VT2 |d OCLCA |d OCLCQ |d OCLCO |d SFB |d OCL |d OCLCQ | ||
| 015 | |a GBB951807 |2 bnb | ||
| 015 | |a GBB950656 |2 bnb | ||
| 016 | 7 | |a 019308776 |2 Uk | |
| 019 | |a 1097612461 |a 1150110992 |a 1244443244 | ||
| 020 | |a 9780128157244 |q (electronic bk.) | ||
| 020 | |a 0128157240 |q (electronic bk.) | ||
| 020 | |a 9780128157237 |q (electronic bk.) | ||
| 020 | |a 0128157232 |q (electronic bk.) | ||
| 035 | |a (OCoLC)1097248779 |z (OCoLC)1097612461 |z (OCoLC)1150110992 |z (OCoLC)1244443244 | ||
| 050 | 4 | |a RC661.A1 | |
| 060 | 4 | |a QV 241 | |
| 072 | 7 | |a HEA |x 039000 |2 bisacsh | |
| 072 | 7 | |a MED |x 014000 |2 bisacsh | |
| 072 | 7 | |a MED |x 022000 |2 bisacsh | |
| 072 | 7 | |a MED |x 112000 |2 bisacsh | |
| 072 | 7 | |a MED |x 045000 |2 bisacsh | |
| 082 | 0 | 4 | |a 616.462061 |2 23 |
| 245 | 0 | 0 | |a Discovery and development of therapeutics from natural products against neglected tropical diseases / |c edited by Goutam Brahmachari. |
| 264 | 1 | |a Amsterdam : |b Elsevier, |c 2019. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Natural product drug discovery | |
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed April 17, 2019) | |
| 505 | 0 | |a Front Cover; Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases; Copyright Page; Dedication; Contents; List of Contributors; Editor Biography; Foreword; Preface; 1 Therapeutics from natural products against neglected tropical diseases: an overview; 1.1 Introduction; 1.2 An overview of the book; 1.3 Concluding remarks; 2 Marine natural products as strategic prototypes in the development of a new generation of antimalarial agents; 2.1 Introduction; 2.2 Antimalarial marine natural products; 2.2.1 Phenolic compounds and polyketides | |
| 505 | 8 | |a 2.2.2 Terpenoids2.2.3 Endoperoxides and polyethers; 2.2.4 Alkaloids; 2.2.5 Peptides and depsipeptides; 2.2.6 Phosphotriesters; 2.3 Concluding remarks; List of abbreviations; References; Further reading; 3 Sesquiterpene lactones: a versatile class of structurally diverse natural products and their semisynthetic analogs as pot ... ; 3.1 Introduction; 3.2 Antimalarial potential of plant derived sesquiterpene lactones; 3.2.1 Artemisinin and its C-12 oxa (ether/ester) derivatives; 3.2.1.1 Synthesis of C-12 carba-derivatives of artemisinin | |
| 505 | 8 | |a 3.2.1.2 Synthesis of C-13 substituted derivatives of artemisinin from artemisitene3.2.1.3 Artemisinin dimers, trimers, and tetramers: novel leads in drug discovery; 3.2.1.4 Synthesis of artemisinin dimers; 3.2.1.5 Synthesis of artemisinin trimers and tetramers; 3.2.2 Germacranolides, guaianolides, and pseudoguiainolides antimalarials SLs; 3.2.2.1 Germacranolides; 3.2.2.2 Guaianolides and pseudoguaianolides; 3.2.3 Miscellaneous antimalarial sesquiterpene lactones; 3.3 Structural-activity relationships of sesquiterpene lactones; 3.4 Concluding remarks; Acknowledgments; List of abbreviations | |
| 505 | 8 | |a 4.6 Natural sources of quinoline alkaloids with antiparasitic activity4.7 Synthetic efforts for targeted quinoline compounds; 4.7.1 Synthesis of polyfunctionalized quinolines from unsubstituted anilines: Route A; 4.7.2 Synthesis of polyfunctionalized quinolines from ortho-substituted anilines: Route B; 4.8 Quinoline compounds as antitrypanosomal agents; 4.8.1 Simple polyfunctionalized quinolines; 4.8.2 Polycyclic quinoline molecules; 4.9 Concluding remarks; Acknowledgment; List of abbreviations; References; Further reading | |
| 520 | |a Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 650 | 0 | |a Hypoglycemic agents |x Development. | |
| 650 | 0 | |a Materia medica. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 1 | 2 | |a Biological Products |x pharmacology |0 (DNLM)D001688Q000494 |
| 650 | 2 | 2 | |a Drug Design |0 (DNLM)D015195 |
| 650 | 2 | 2 | |a Drug Development |0 (DNLM)D000076722 |
| 650 | 2 | 2 | |a Neglected Diseases |x drug therapy |0 (DNLM)D058069Q000188 |
| 650 | 2 | 2 | |a Tropical Medicine |x methods |0 (DNLM)D014330Q000379 |
| 650 | 6 | |a Hypoglyc�emiants |0 (CaQQLa)201-0022942 |x D�eveloppement. |0 (CaQQLa)201-0375083 | |
| 650 | 6 | |a Mati�ere m�edicale. |0 (CaQQLa)201-0000918 | |
| 650 | 6 | |a M�edicaments |x Conception. |0 (CaQQLa)201-0203461 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Drugs |x Design. |2 fast |0 (OCoLC)fst00898790 | |
| 650 | 7 | |a Materia medica. |2 fast |0 (OCoLC)fst01011707 | |
| 700 | 1 | |a Brahmachari, Goutam, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Discovery and development of therapeutics from natural products against neglected tropical diseases. |d Amsterdam : Elsevier, 2019 |z 9780128157237 |w (OCoLC)1090442378 |
| 830 | 0 | |a Natural product drug discovery. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128157237 |z Texto completo |