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Nanoparticles in pharmacotherapy /
Nanoparticles in Pharmacotherapy explores the most recent findings on how nanoparticles are used in pharmacotherapy, starting with their synthesis, characterization and current or potential uses. This book is a valuable resource of recent scientific progress that includes the most cutting-edge appli...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands ; Oxford, United Kingdom ; Cambridge, MA, United States :
Elsevier,
[2019]
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| Colección: | Micro & nano technologies.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Nanoparticles in Pharmacotherapy; Copyright Page; Contents; List of Contributors; Foreword; Preface; 1 Pharmacotherapy and nanotechnology; 1.1 Introduction; 1.2 Carriers for Antiinfective Therapy; 1.3 Carriers for Antiinflammatory Therapy; 1.4 Carriers for Anticancer Therapy; 1.5 Conclusions; References; 2 Nanostructures in pharma: elixir to oral medicine; 2.1 Nanocrystals; 2.1.1 Mechanism of Nanocrystals Improved Performance and Properties; 2.1.1.1 Surface area; 2.1.1.2 Apparent solubility and supersaturation; 2.1.1.3 Amorphous state of the nanocrystals
- 2.1.2 Manufacturing of Nanocrystals2.1.3 Bottom-Up Techniques; 2.1.3.1 Nanoprecipitation; 2.1.3.2 Supercritical fluid processing; 2.1.3.3 Spray drying; 2.1.3.4 Freeze drying; 2.1.3.5 Others; 2.1.4 Top-Down Techniques; 2.1.4.1 Nanomilling/media milling; 2.1.4.2 High pressure homogenization; 2.1.5 General Issues: Cause, Effect, and Solution; 2.1.5.1 Crystal growth and agglomeration; 2.1.5.2 Polymorphism; 2.1.6 Characterization of Nanocrystals; 2.1.6.1 Particle size analysis; 2.1.6.2 Physical testing; 2.1.6.3 Morphology; 2.1.6.4 Dispersion testing; 2.1.6.5 Chemical analysis
- 2.2 Polymeric Nanoparticles2.2.1 In Vivo Evaluation of Oral Nanoparticles; 2.2.1.1 Types of in vivo evaluation tests; 2.2.1.2 Pharmacokinetic studies; 2.2.1.3 Drug efficacy studies; 2.2.1.4 Drug transport and distribution studies; 2.2.1.5 Histopathological examination studies; 2.2.2 Characterization of the Nanoparticles by Various Techniques; 2.2.2.1 Particle size and distribution; 2.2.2.1.1 Photon-correlation spectroscopy; 2.2.2.1.2 Scanning electron microscopy; 2.2.2.1.3 Transmission electron microscopy; 2.2.2.1.4 Cryo-transmission electron microscopy; 2.2.2.1.5 Atomic force microscopy
- 2.2.2.2 Molecular weight2.2.2.2.1 Gel chromatography; 2.2.2.3 Surface charge; 2.2.2.3.1 Zeta potential measurement; 2.2.2.3.2 Laser Doppler anemometry; 2.2.2.4 Hydrophobicity; 2.2.2.5 Surface element analysis; 2.2.2.5.1 X-ray photon spectroscopy; 2.2.2.5.2 Nuclear magnetic resonance; 2.2.3 Nanoparticles-brain delivery; 2.3 Future Directions and Conclusions; References; 3 Polymeric micelles in biomedical science; 3.1 Introduction; 3.2 Preparation of Polymeric Micelles; 3.2.1 Synthetic Strategies for Polymeric Micelles; 3.2.1.1 Conventional approach; 3.2.1.2 Polyion complex micelles
- 3.2.1.3 Noncovalent approach3.3 Preparation of Drug-Loaded Polymeric Micelles; 3.3.1 Direct Dissolution Method; 3.3.2 Solvent Evaporation; 3.3.3 Dialysis; 3.3.4 Lyophilization Method; 3.4 Characterization of Polymeric Micelles; 3.4.1 Critical Micelle Concentration; 3.4.2 Size and Shape of Polymeric Micelles; 3.4.3 Electrophoretic Measurements; 3.4.4 Nuclear Magnetic Resonance; 3.4.5 Differential Scanning Calorimetry; 3.4.6 Flow Cytometry Analysis; 3.4.7 Stability of Polymeric Micelles; 3.5 Application of Polymeric Micelles in Biomedical Sciences; 3.5.1 Passive Drug Targeting