Basic and applied bone biology /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Burr, David B. (Editor ), Allen, Matthew R. (Professor of anatomy and cell biology) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, United Kingdom : Academic Press, an imprint of Elsevier, [2019]
Edición:Second edition.
Temas:
Bones.
Bone and Bones
Os.
bonnets (hats)
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • BASIC AND APPLIED BONE BIOLOGY
  • BASIC AND APPLIED BONE BIOLOGY
  • Copyright
  • Dedication
  • Contents
  • List of Contributors
  • Biographies
  • Preface (First Edition)
  • Preface (Second Edition)
  • I
  • BASIC BONE BIOLOGY AND PHYSIOLOGY
  • 1
  • Bone Morphology and Organization
  • THE FUNCTIONS OF BONE
  • BONE IS ORGANIZED AS A MULTISCALE MATERIAL
  • BONE COMPOSITION
  • THE NANOSCALE ORGANIZATION OF BONE
  • Collagen
  • Enzymatically Mediated Collagen Cross-Linking
  • Nonenzymatically Mediated Collagen Cross-Linking
  • Collagen Orientation
  • Bone Mineral
  • Noncollagenous Extracellular Matrix Proteins
  • Proteoglycans and Glycosaminoglycans
  • Glycoproteins
  • SIBLING Proteins
  • Osteocalcin
  • Osteonectin
  • THE MICROSTRUCTURAL ORGANIZATION OF BONE
  • Woven Bone
  • Primary Bone
  • Primary Lamellar Bone
  • Plexiform Bone
  • Primary Osteons
  • Secondary Bone
  • Interstitial Bone
  • THE MACROSCOPIC ORGANIZATION OF BONE
  • Cortical Bone
  • Skeletal Envelopes
  • THE BLOOD SUPPLY AND INNERVATION OF BONE
  • Blood Supply
  • Innervation of Bone
  • BONE FLUID COMPARTMENTS
  • BONE MASS AND BONE QUALITY
  • Rate of Bone Turnover
  • Bone Trabecular Architecture
  • Tissue Material (Intrinsic) Properties
  • Microdamage Accumulation
  • Suggested Readings
  • 2
  • Bone Marrow and the Stem Cell Niche
  • NICHES IN DEVELOPMENT
  • IMAGING OF NICHES
  • BONE MARROW NICHE CELLS
  • Nonhematopoietic
  • Osteoblastic Cells
  • Mesenchymal Stromal/Stem Cell Populations
  • Adipocytes
  • Endothelial Cells
  • Hematopoietic
  • Megakaryocytes
  • Macrophages
  • Neutrophils
  • Osteoclasts
  • NEURONAL REGULATION OF THE HEMATOPOIETIC STEM CELL NICHE
  • HORMONAL REGULATION OF THE HEMATOPOIETIC STEM CELL NICHE
  • NICHES AND MALIGNANCIES
  • AGING AND THE BONE MARROW MICROENVIRONMENT
  • THE FUTURE
  • Suggested Readings
  • 3
  • Bone Cells
  • OSTEOCLASTS
  • Osteoclast Morphology and Function
  • Osteoclast Differentiation and Fusion
  • Osteoclast Apoptosis
  • Regulation of Osteoclast Generation and Survival
  • OSTEOBLASTS
  • Osteoblast Morphology and Function
  • Osteoblast Formation and Differentiation
  • Osteoblast Apoptosis
  • Regulation of Osteoblast Generation and Survival
  • Bone Lining Cells
  • OSTEOCYTES
  • Osteocyte Morphology and Functions
  • Osteocytogenesis and Osteocyte Maturation
  • Osteocyte Apoptosis: Consequences and Regulation
  • Preservation of Osteocyte Viability by Mechanical Stimuli
  • Aging and Osteocyte Apoptosis
  • Hormonal Regulation of Osteocyte Life Span
  • Regulation of Bone Formation by Osteocytes: The Sclerostin Paradigm
  • Regulation of Bone Resorption by Osteocytes: RANKL and OPG
  • Regulation of Bone Mineralization by Osteocytes
  • Suggested Readings
  • 4
  • Local Regulation of Bone Cell Function
  • OVERVIEW OF CYTOKINES AND GROWTH FACTORS AND THEIR RECEPTORS
  • Definition: Cytokines Versus Growth Factors
  • Soluble Ligands
  • Membrane-Bound Ligands
  • Receptor Classification
  • Signal Transduction Cascades

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