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Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders /
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a var...
| Clasificación: | Libro Electrónico |
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| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press, an imprint of Elsevier,
[2019]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders; Copyright; Contents; Contributors; About the Editors and Acknowledgements; Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders; Preface; Part 1: Applications of Nitric Oxide in Cancer; Chapter 1: Nitric Oxide-Releasing Engineered Nanoparticles: Tools for Overcoming Drug Resistance in Chemotherapy; Conflict of Interest; Introduction: Overview of Nitric Oxide in Cancer Biology; Nanotechnology in Cancer: The Enhanced Permeability and Retention Effect Allied to NO Donors
- Combination of NO-Releasing Nanomaterials and Conventional Anticancer ChemotherapiesSelected Examples of NO-Releasing Nanomaterials for Cancer Treatment; Conclusions: Perspectives and Challenges; Acknowledgments; References; Chapter 2: Reversal of Multiple Cancer Oncogenic Pleiotropic Properties by NO-Modulating Therapies; Conflict of Interest; Introduction; Antineoplastic Activities of NO in Cancer Cells and the Underlying Molecular Mechanisms; NO and Tumor Initiation, Growth, and Apoptosis; NO and Tumor Metastasis; NO and Tumor Cell Stemness
- NO and Tumor Resistance to Conventional Chemotherapy and Immune-Mediated CytotoxicityAntineoplastic Activities of NO in Tumor Milieu and the Underlying Molecular Mechanisms; NO and Tumor Angiogenesis; NO and Immunoediting of Immune Signals by the Tumor Microenvironment; Nitric Oxide Novel Applications in Cancer Treatment and Prevention; NO Donors; NO Donor Conjugates; NO-Releasing Nanoparticles; NOS Gene Targeting; Conclusions; Acknowledgment; References; Chapter 3: Antitumor Effect of a Metal-Nonoate Through Angiogenesis Impairment; Conflict of Interest; Introduction; Results; Conclusions
- AcknowledgmentsReferences; Chapter 4: Therapeutic Implications of the Nitric Oxide Pathway in the Angiogenesis of Tumors and Inflammatory-Related Di ... ; Conflict of Interest; Angiogenesis: Definition and Pathophysiological Roles; Regulation of Endogenous NO Production and Vascular Physiology; Role of NO in Angiogenesis; How NO Controls Angiogenesis; Direct Effects of NO on Endothelial Cells; NO as a Mediator of the Angiogenic Factor Activity; NOS Inhibition as Effector of Antiangiogenic Molecules and Antitumor Drugs
- NO Controls the Angiogenic Modulator Expression or Activity in Endothelial, Tumor, and Stromal CellsContadictory Roles of NO in Tumor Angiogenesis; Innovative Strategies for Controlled NO Availability; Conclusions; Acknowledgments; References; Chapter 5: Nitric Oxide and Cancer: To Inhibit or To Induce iNOS: That Is the Question?; Conflict of Interest; NO: Its Generation and Signaling; NO and Cancer; iNOS Inhibition Strategies; iNOS Induction Strategies; Does Exposure to NO Cause Human Cancer?; The Tumor Microenvironment: iNOS, Innate Immunity, and Cancer; Final Thoughts and Future Directions