AGO-driven non-coding RNAs : codes to decode the therapeutics of diseases /

The 'RNA world' hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes....

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mallick, Bibekanand (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London ; San Diego, CA : Academic Press, [2019]
Temas:
Non-coding RNA.
RNA-protein interactions.
RNA, Small Untranslated
Argonaute Proteins
RNA, Untranslated
ARN non codants.
Interactions ARN-prot�eines.
Prot�eines Argonautes.
SCIENCE > Life Sciences > Biochemistry.
Non-coding RNA
RNA-protein interactions
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover; AGO-Driven Non-Coding RNAs: Codes to Decode the Therapeutics of Diseases; Copyright; Contents; Contributors; About the Editor; Preface; About the Book; Part: 1 Small non-coding RNA biology and prediction methods; Chapter 1 Two different mechanisms of two different non-coding RNAs-MicroRNAs and PIWI-interacting RNAs: From origin to ca ... ; 1 History of MicroRNAs; 2 Biogenesis of MicroRNAs; 3 Functions of MicroRNAs; 3.1 Roles of MicroRNAs and Their Effects on Cancer; 3.1.1 Tumor suppressor microRNAs; 3.1.2 Oncogenic microRNAs (oncomiRs); 3.1.3 MetastamiRs
  • 4 History of PIWI-Interacting RNAs5 Classification of piRNAs; 6 Biogenesis of piRNAs; 6.1 The Primary Pathway; 6.2 The Secondary/Amplification Loop (Ping-Pong) Pathway; 7 Functions of piRNAs and PIWI Proteins; 8 piRNAs/PIWI Proteins and Cancer; 9 Conclusion; References; Chapter 2 Computational methods for microRNA and PIWI-interacting RNA gene discovery and functional predictions; 1 Introduction; 2 Computational Methods for the Identification of MicroRNA Genes; 2.1 MicroRNA Biogenesis and Function; 2.2 Ab Initio MicroRNA Discovery
  • 2.3 High-Throughput RNA Sequencing Analysis for MicroRNA Discovery2.4 Functional Validation of Predicted MicroRNA Genes; 3 Computational Identification of PIWI-Interacting RNAs; 4 Computational Methods to Predict MicroRNA's Functions; 4.1 In Silico Methods and Tools to Infer microRNAs' Function; 4.2 Predict MicroRNA-Disease Associations; 4.3 Network-Based Approaches for MicroRNA's Functional Prediction; 5 Exploration of PIWI-Interacting RNA's Functions Using In Silico Methods; 6 Conclusion; References; Part: 2 Small ncRNAs dictating cell fate and immune response
  • Chapter 3 The role of microRNAs in bacterial infections1 Introduction; 2 Mammalian Toll-Like Receptors and Bacterial Infection; 3 MicroRNAs Regulating the Inflammatory Response of Immune Cells to Infection; 4 Autophagy and Its Regulation During Bacterial Infection; 5 Concluding Remarks; Acknowledgments; References; Chapter 4 MicroRNAs shaping cellular reprogramming; 1 Introduction; 2 MicroRNAs and Cellular Reprogramming; 2.1 Importance of MicroRNA in Pluripotent Stem Cells; 2.1.1 miR-17~92 cluster; 2.1.2 miR-290 ~ 295 cluster; 2.1.3 miR-302 ~ 367 cluster
  • 2.1.4 Let-7 microRNAs reverse the effect of pluripotency-promoting microRNAs2.2 MicroRNAs Serve as Key Players in Cellular Reprogramming; 2.3 Influence of Metabolic Signaling Pathways and Cell Culture Conditions on MicroRNA Expression and Function in Reprogra ... ; 3 Role of MicroRNAs in Reprogramming Associated Cellular Events; 3.1 Regulation of Cell Cycle; 3.2 Regulation of Mesenchymal to Epithelial Transition; 3.3 Regulation of DNA Methylation; 3.4 Regulation of Cell Apoptosis; 3.5 Regulation of the p53 Pathway; 4 Role of MicroRNAs in Trans-Differentiation

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