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Aldosterone /
Aldosterone, Volume 109, the latest release in the Vitamins and Hormones series first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics relating to Aldosterone Research, Aldosterone a...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA, United States :
Academic Press,
2019.
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| Edición: | First edition. |
| Colección: | Vitamins and Hormones ;
109 |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro; Title page; Table of Contents; Copyright; Former Editors; Contributors; Preface; Chapter One: Aldosterone Research: 65 Years, and Counting; Abstract; Chapter Two: Evolution of the Mineralocorticoid Receptor; Abstract; 1 Introduction; 2 The MR Consists of Multiple Functional Domains; 3 Evolution of the MR Steroid-Binding Domain; 4 Aldosterone, the Terrestrial Vertebrate Mineralocorticoid, Is at the End of the Pathway for Corticosteroid Synthesis; 5 Diverse Steroids Have High Affinity for the MR; 6 Diverse Steroids Have Different Transcriptional Activity for the MR
- 7 An Evolutionary Puzzle: Progesterone Is a MR Antagonist in Humans and a MR Agonist in Ray-Finned Fish8 Conclusion; Acknowledgment; Conflict of Interest; Funding; Author Contributions; Chapter Three: Mechanisms of Mineralocorticoid Receptor Signaling; Abstract; 1 Introduction; 2 Target Tissues and Ligand Access; 3 MR Structure and Function; 4 The Ligand-MR Interaction; 5 An Interaction Between the NTD and the LBD: The N/C-Interaction; 6 DNA Binding; 7 Coregulators for the MR; 8 Conclusions; Acknowledgments; Conflict of Interest; Chapter Four: Regulation of Aldosterone Signaling by MicroRNAs
- Abstract1 Introduction to Non-Coding RNAs; 2 MiR Production; 3 Regulation of MiR Expression by Aldosterone; 4 MiR Regulation of Aldosterone Signaling; 5 Regulation of Related Steroid Hormone Signaling by MiRs; 6 MiR Role in Modulating Aldosterone Effects in the Kidney; 7 MiR Regulation of Other Kidney Transporters and Regulatory Proteins; 8 MiRs in Aldosterone-Related Disease; Acknowledgments; Chapter Five: Aldosterone and Ion Channels; Abstract; 1 Introduction; 2 Sodium Channels; 3 Potassium Channels; 4 Calcium Channels; 5 Chloride Channels; 6 Conclusions and Future Directions
- AcknowledgmentsChapter Six: Non-Genomic Effects of Aldosterone; Abstract; 1 Introduction; 2 Extra-Nuclear, Non-Genomic Actions Linked to Genomic Actions of Aldosterone; 3 Role of Second Messenger Pathways; 4 Controversy of Which Receptor Involved in Non-Genomic Actions of Aldosterone; 5 Gender Differences in MR Activation: Modeling Sex Hormone-MR Interactions; 6 Conclusion; Chapter Seven: Mineralocorticoid Receptor Antagonists; Abstract; 1 Clinical Use of Mineralocorticoid Receptor Antagonists; 2 Specific Challenges in Designing Mineralocorticoid Receptor Antagonists
- 3 MR Antagonists That Fit in the Aldosterone Binding Site4 MR Antagonists That Utilize the Met852 Pocket; 5 The Helix 6-7 Induced Pocket; 6 Aromatic Sulfonamides as MR Antagonists; 7 Pyrrole Derivatives as MR Antagonists; 8 The 1,4-Dihydropyridine Class of MR Antagonists; 9 The Pyrazoline Class of MR Antagonists; 10 Oxazolidinone Derivatives as MR Antagonists; 11 MR Antagonists With a Tricyclic Scaffold; 12 Summary; Chapter Eight: Adipocyte Mineralocorticoid Receptor; Abstract; 1 Introduction: The Adipose Organ; 2 Adipocyte Mineralocorticoid Receptor (MR) and Adipogenesis