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Basic fundamentals of drug delivery /
Basic Fundamentals of Drug Delivery covers the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable drug delivery system. The bo...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom ; San Diego, CA :
Academic Press, an imprint of Elsevier,
[2019]
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| Colección: | Advances in pharmaceutical product development and research series.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Basic fundamentals of drug delivery / |c edited by Rakesh K. Tekade (National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, Gujarat, India, formerly with the Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia). |
| 264 | 1 | |a London, United Kingdom ; |a San Diego, CA : |b Academic Press, an imprint of Elsevier, |c [2019] | |
| 264 | 4 | |c �2019 | |
| 300 | |a 1 online resource : |b color illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in pharmaceutical product development and research series | |
| 520 | |a Basic Fundamentals of Drug Delivery covers the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable drug delivery system. The book also covers various approaches involved in optimizing the therapeutic performance of a biomolecule while designing its appropriate advanced formulation. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed December 10, 2018). | |
| 505 | 0 | |a Front Cover; Basic Fundamentals of Drug Delivery; Copyright Page; Dedication; Contents; List of Contributors; About the Editor; 1 Scientific Rationale for Designing Controlled Drug Delivery Systems; 1.1 Conventional Drug Delivery Systems and Limitations; 1.2 Controlled Release Drug Delivery System; 1.2.1 Historical Perspective; 1.2.2 Concept and Understanding; 1.2.3 Advantages of CRDDS Over Conventional Delivery Systems; 1.2.4 Compounds That Are Unsuitable for CRDDS; 1.3 Design of CRDDS: Understanding of Factors; 1.3.1 Physicochemical Properties of Drug and Design Considerations | |
| 505 | 8 | |a 1.3.2 Pharmacokinetic/Dynamic Considerations1.3.3 Polymers for CRDDS; 1.3.3.1 Synthetic Polymers; 1.3.3.2 Natural Polymers; 1.3.3.3 Smart Polymers; 1.3.3.3.1 pH-sensitive Polymers; 1.3.3.3.2 Temperature Sensitive Polymers; 1.3.3.3.3 Ion Exchange Polymers; 1.4 Approaches for the Design of CRDDS; 1.4.1 Chemical Approach; 1.4.2 Biological Approach; 1.4.3 Pharmaceutical Approach; 1.5 Medical Rationale of CRDDS; 1.5.1 Reduction in Dosing Frequency; 1.5.2 Lesser Drug Exposure to the Biological Environment; 1.5.3 Minimization of Plasma Concentration Fluctuations; 1.5.4 Better Patient Compliance | |
| 505 | 8 | |a 1.5.5 Lower Adverse/Side Effects1.5.6 Augmented Efficacy; 1.6 The Biological Rationale for CRDDS; 1.6.1 Absorption; 1.6.2 Drug-Protein Binding; 1.6.3 Distribution; 1.6.4 Elimination; 1.6.5 Dose-Dependent Bioavailability; 1.6.6 Duration of Drug Residence Within the Therapeutic Window; 1.6.7 Better Safety Margin; 1.6.8 Individualization in a Diseased Condition; 1.7 Conclusion; Acknowledgment; Abbreviations; References; 2 Current Developments in Excipient Science: Implication of Quantitative Selection of Each Excipient in Product Development; 2.1 An Introduction to Excipient Science | |
| 505 | 8 | |a 2.1.1 History of Use of Excipients in Pharmaceutical Formulations2.1.2 Need and Rationale Behind the Use of Excipients; 2.1.3 Why Is the Pharma Industry Not Taking Interest to Develop and Use Novel Excipients?; 2.1.4 Role of Excipients in Pharmaceutical Formulations; 2.1.5 Criteria for Selection of Excipients; 2.1.6 Coprocessed Excipients; 2.1.7 Ideal Properties of Excipients; 2.2 Excipients Used in Different Dosage Formulations: Role in Product Development; 2.2.1 Excipients Used in the Solid Dosage Form; 2.2.1.1 Antiadherent and Lubricants; 2.2.1.2 Binders; 2.2.1.3 Disintegrants | |
| 505 | 8 | |a 2.2.1.3.1 Characteristics of Disintegrants2.2.1.3.2 Factors Affecting the Action of Disintegrants; 2.2.1.4 Fillers; 2.2.1.4.1 Sugars; 2.2.1.4.2 Lactose; 2.2.1.4.3 Dextrose; 2.2.1.4.4 Sucrose; 2.2.1.4.5 Mannitol; 2.2.1.4.6 Starch and Its Derivatives; 2.2.1.4.7 Celluloses; 2.2.1.4.8 Inorganic Compounds; 2.2.1.5 Flavoring Agents; 2.2.1.6 Sweeteners; 2.2.1.7 Coloring Agent; 2.2.1.8 Glidants; 2.2.1.9 Sorbents; 2.2.1.10 Preservatives; 2.2.2 Excipients Used in the Liquid Dosage Form; 2.2.2.1 Solvents; 2.2.2.2 Cosolvents; 2.2.2.3 Sequestering Agents; 2.2.2.4 Buffers and Buffering Agents; 2.2.2.5 Flavoring Agents | |
| 650 | 0 | |a Drug delivery systems. | |
| 650 | 1 | 2 | |a Drug Delivery Systems |0 (DNLM)D016503 |
| 650 | 6 | |a Syst�emes d'administration de m�edicaments. |0 (CaQQLa)000260397 | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Drug delivery systems |2 fast |0 (OCoLC)fst00898667 | |
| 700 | 1 | |a Tekade, Rakesh K., |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Basic fundamentals of drug delivery. |d London, United Kingdom ; San Diego, CA : Academic Press, an imprint of Elsevier, [2019] |z 0128179090 |z 9780128179093 |w (OCoLC)1050607822 |
| 830 | 0 | |a Advances in pharmaceutical product development and research series. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128179093 |z Texto completo |