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Human Population Genetics and Genomics /
Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating,...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
2018.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Human Population Genetics and Genomics; Human Population Genetics and Genomics; Copyright; Dedication; Contents; Preface; 1
- DEFINITION, SCOPE, AND PREMISES OF HUMAN POPULATION GENETICS; THE BASIC PREMISES OF POPULATION GENETICS; PREMISE 1: DNA CAN REPLICATE; PREMISE 2: DNA CAN MUTATE AND RECOMBINE; PREMISE 3: DNA AND THE ENVIRONMENT INTERACT TO PRODUCE PHENOTYPES; NATURAL SELECTION AND THE INTEGRATION OF THE THREE PREMISES; REFERENCES; 2
- THE HUMAN GENOME; COMPONENTS OF THE NUCLEAR GENOME; GENES; TRANSPOSABLE ELEMENTS; REPETITIVE DNA; CG ISLANDS; CENTROMERES; TELOMERES.
- THE TRANSCRIPTOMETHE EXOME, SPLICEOSOME, AND PROTEOME; EPIGENOME; THE MITOCHONDRIAL GENOME; MUTATION AND RECOMBINATION IN THE HUMAN GENOMES; MUTATION; RECOMBINATION; REFERENCES; 3
- SYSTEMS OF MATING; RANDOM MATING AND THE HARDY-WEINBERG LAW; INBREEDING; PEDIGREE INBREEDING; SYSTEM OF MATING INBREEDING; ASSORTATIVE MATING; DISASSORTATIVE MATING; COEXISTENCE OF MULTIPLE SYSTEMS OF MATING WITHIN A DEME; REFERENCES; 4
- GENETIC DRIFT; THE FATE OF A NEWLY ARISEN MUTATION IN A LARGE POPULATION; GENETIC DRIFT IN A FINITE POPULATION; EFFECTIVE POPULATION SIZES.
- GENETIC DRIFT AND LINKAGE DISEQUILIBRIUMGENETIC DRIFT AND NEUTRAL MUTATIONS; REFERENCES; 5
- A BACKWARD VIEW OF GENETIC DRIFT: COALESCENCE; BASIC COALESCENT MODEL; COALESCENCE WITH MUTATION; HAPLOTYPE TREES; HAPLOTYPE TREES, POPULATION TREES, AND SPECIES TREES; COALESCENCE AND RECOMBINATION; REFERENCES; 6
- GENE FLOW AND SUBDIVIDED POPULATIONS; A TWO-DEME MODEL OF GENE FLOW; THE BALANCE OF GENE FLOW AND GENETIC DRIFT; GENDER-BIASED GENE FLOW; SYSTEM OF MATING AND GENE FLOW; KIN-STRUCTURED MIGRATION; ADMIXTURE; ISOLATION BY DISTANCE AND RESISTANCE; IDENTIFYING HUMAN SUBPOPULATIONS.
- POPULATION SUBDIVISION, ISOLATION-BY-DISTANCE, AND EFFECTIVE POPULATION SIZESREFERENCES; 7
- HUMAN POPULATION HISTORY OVER THE LAST TWO MILLION YEARS; HAPLOTYPE TREES AS A WINDOW INTO THE PAST; POPULATION TREES; ANCIENT DNA-THE ORIGINS OF THE HUMAN GENE POOL; ANCIENT DNA-THE LAST 25,000YEARS; REFERENCES; 8
- GENOTYPE AND PHENOTYPE; FISHER'S QUANTITATIVE GENETIC MODEL; CLASSICAL HUMAN QUANTITATIVE GENETIC ANALYSIS; MEASURED GENOTYPE APPROACHES TO QUANTITATIVE GENETICS; LINKAGE MAPPING; RUNS OF HOMOZYGOSITY; ADMIXTURE MAPPING; GENOME-WIDE ASSOCIATION STUDIES.
- CLASSICAL QUANTITATIVE GENETICS VERSUS MEASURED GENOTYPE APPROACHESREFERENCES; 9
- NATURAL SELECTION; A ONE-LOCUS, TWO-ALLELE MODEL OF NATURAL SELECTION; SICKLE-CELL AND MALARIAL ADAPTATIONS: AN EXAMPLE OF THE MEASURED GENOTYPE APPROACH TO NATURAL SELECTION; A QUANTITATIVE GENETIC, UNMEASURED GENOTYPE MODEL OF NATURAL SELECTION; REFERENCES; 10
- DETECTING SELECTION THROUGH ITS INTERACTIONS WITH OTHER EVOLUTIONARY FORCES; INTERACTION OF SELECTION WITH MUTATION; INTERACTIONS OF SELECTION WITH MUTATION AND GENETIC DRIFT; INTERACTIONS OF SELECTION WITH MUTATION, GENETIC DRIFT, AND RECOMBINATION.