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Progress in molecular biology and translational science. Volume 159 /
'Progress in Molecular Biology and Translational Science' provides in-depth reviews on topics of exceptional scientific importance. Each volume is edited by an internationally recognized expert who selects contributors at the forefront of each field.
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press,
2018.
|
| Colección: | Progress in molecular biology and translational science ;
159. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a Progress in molecular biology and translational science. |n Volume 159 / |c edited by David B. Teplow. |
| 264 | 1 | |a Cambridge, MA : |b Academic Press, |c 2018. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed October 24, 2018) | |
| 500 | |a Includes index. | ||
| 520 | 8 | |a 'Progress in Molecular Biology and Translational Science' provides in-depth reviews on topics of exceptional scientific importance. Each volume is edited by an internationally recognized expert who selects contributors at the forefront of each field. |b Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and drug addiction, Arrestin Structure-Function, Arrestins in the Cardiovascular System, Analysis of biased agonism, and more. | |
| 505 | 0 | |a Front Cover -- Progress in Molecular Biology and Translational Science -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Targeting the Recently Deorphanized Receptor GPR83 for the Treatment of Immunological, Neuroendocrine and Ne ... -- 1. Introduction -- 1.1. Discovery of GPR83 -- 1.2. Discovery of proSAAS and the Signaling Peptide PEN -- 1.3. ProSAAS Expression and Function -- 2. Expression and Significance of GPR83 in the Brain -- 2.1. Expression of GPR83 in the Mouse Brain -- 2.2. Differential GPR83 Expression Between Mouse, Rat and Human -- 2.3. Regulation of GPR83 Expression in the Brain -- 2.4. Role of GPR83 in Hypothalamic Function -- 2.5. Role of GPR83 in Stress, Reward and Learning and Memory -- 3. Role of GPR83 in Immune Function -- 3.1. Expression of GPR83 in Immune Cells -- 3.2. Significance of GPR83 in Immune Function -- 4. Current Understanding of GPR83 and PEN -- 4.1. The Deorphanization of GPR83 -- 5. Conclusions -- 5.1. Relationship Between GPR83, Stress, Reward, and Immune Function: Future Research Considerations -- 5.2. The GPR83-PEN Neuropeptide System as a Novel Therapeutic Drug Target -- 5.3. Summary -- Acknowledgment -- References -- Chapter Two: Arrestins in the Cardiovascular System: An Update -- 1. Introduction -- 2. Cardiovascular Adrenergic Receptors and �arrestins -- 2.1. Cardiovascular �I�ARs and �arrestins -- 2.2. Cardiac �ARs and �arrestins -- 2.3. Other Cardiovascular �ARs and �arrestins -- 3. Cardiovascular Angiotensin II Receptors and �arrestins -- 3.1. Cardiac AT1Rs and �arrestins -- 3.2. Vascular AT1Rs and �arrestins -- 3.3. Adrenal AT1Rs and �arrestins -- 4. Other Cardiovascular GPCRs and �arrestins -- 4.1. Endothelin Receptors -- 4.2. Vasopressin Receptors -- 4.3. Niacin Receptor (GPR109A) -- 4.4. P2Y Receptors -- 4.5. Protease-Activated Receptors -- 4.6. Apelin Receptor. | |
| 505 | 8 | |a 4.7. Sphingosine-1-Phosphate 1 Receptor -- 5. Therapeutic Implications of the Functional Divergence of Cardiovascular �arrestins -- 6. Conclusions and Future Perspectives -- References -- Chapter Three: Global Aquatic Hazard Assessment of Ciprofloxacin: Exceedances of Antibiotic Resistance Development and Ec ... -- 1. Background -- 2. Materials and Methods -- 2.1. Literature Review -- 2.2. Probabilistic Aquatic Hazard Assessments -- 3. Results and Discussion -- 3.1. Ciprofloxacin in Municipal and Hospital Sewage and Effluent Discharges -- 3.2. Ciprofloxacin in Freshwater, Marine Systems and Groundwater -- 4. Conclusions -- References -- Chapter Four: Group I Intron-Based Therapeutics Through Trans-Splicing Reaction -- 1. Introduction -- 2. Group I Intron -- 2.1. Self-Splicing Activity of Group I Intron -- 2.2. Development of Trans-Splicing Group I Ribozyme -- 3. Group I Intron as Therapeutics -- 3.1. Trans-Splicing Ribozyme for RNA Repair -- 3.2. Trans-Splicing Ribozyme for RNA Reprogramming -- 4. Concluding Remarks -- Acknowledgments -- References -- Chapter Five: Major 32-52 Exoribonucleases in the Metabolism of Coding and Non-coding RNA -- 1. Introduction -- 2. Polynucleotide Phosphorylase -- 2.1. PNPase Function and Regulation -- 2.1.1. PNPase Activity on RNA -- 2.1.2. PNPase Activity on DNA -- 2.1.3. Regulation of PNPase Activity -- 2.1.4. Regulation of PNPase Expression -- 2.2. PNPase Complexes -- 2.3. PNPase Structure -- 2.4. PNPase Substrates -- 2.4.1. PNPase in the Metabolism of Coding RNA -- 2.4.2. PNPase in the Metabolism of Non-coding RNA -- 2.4.3. PNPase in Eukaryotes -- 2.4.4. PNPase in Pathogenesis and Disease -- 3. RNase II -- 3.1. RNase II Function and Regulation -- 3.1.1. RNase II Activity on RNA -- 3.1.2. Regulation of RNase II Activity -- 3.1.3. Regulation of RNase II Expression -- 3.1.4. RNase II Complexes. | |
| 505 | 8 | |a 3.2. RNase II Structure -- 3.3. RNase II Substrates -- 3.3.1. RNase II in the Metabolism of Coding RNA -- 3.3.2. RNase II in the Metabolism of Non-coding RNA -- 4. RNase R -- 4.1. RNase R Function and Regulation -- 4.1.1. RNase R Activity on RNA -- 4.1.2. Regulation of RNase R Stability -- 4.1.3. RNase R Complexes -- 4.2. RNase R Structure -- 4.3. RNase R Substrates -- 4.3.1. RNase R in the Metabolism of Coding RNA -- 4.3.2. RNase R in the Metabolism of Non-coding RNA -- 4.4. RNase II/RNase R in Eukaryotes -- 4.5. RNase II/RNase R Family Members in Pathogenesis and Disease -- 5. Concluding Remarks -- Acknowledgments -- References -- Chapter Six: Different Methods of Delivering CRISPR/Cas9 Into Cells -- 1. Introduction -- 1.1. Programmable Nucleases -- 1.2. Genome Silencing vs Genome Editing -- 1.3. Advantages of CRISPR Over ZFN and TALEN -- 2. Delivery Methods of CRISPR/Cas9 for Genome Editing -- 2.1. Viral-Mediated Delivery -- 2.1.1. Adeno-Associated Viral Vector-Mediated Delivery -- 2.1.2. Lentiviral Vector-Mediated Delivery -- 2.1.3. Adenovirus-Mediated Delivery -- 2.2. Non-viral Vectors -- 2.2.1. Cationic Vectors -- 2.2.2. Cell-Penetrating Peptides -- 2.2.3. Other Non-viral Methods -- 2.3. Physical Methods -- 3. Opportunities and Challenges in CRISPR/Cas9 Delivery to Stem Cells -- 4. Conclusions and Future Perspectives -- Acknowledgments -- References -- Chapter Seven: Structural Simplicity and Mechanistic Complexity in the Hammerhead Ribozyme -- 1. Background and Structural Overview -- 2. Fast Minimal Hammerhead Ribozymes -- 3. Acid-Base Catalysis and the Hammerhead Ribozyme -- 4. Is the Hammerhead Ligation Reaction the Reverse of the Cleavage Reaction? -- 5. Do Cooperative Interactions in the Hammerhead Ribozyme Facilitate General Base Catalysis in the Cleavage Reaction? -- 6. Summary and Concluding Remarks. | |
| 505 | 8 | |a 6.1. The Structure of the Hammerhead Ribozyme May Be Much Simpler Than We Have Thought -- 6.2. The Mechanism of the Hammerhead Ribozyme May Be Much More Complicated Than We Have Thought -- 6.2.1. The Ligation Reaction Mechanism Might Not Be the Reverse of the Cleavage Mechanism -- 6.2.2. General Base Catalysis in the Cleavage Reaction Mechanism Might Be More Complex -- 6.3. Concluding Remarks -- References -- Index -- Back Cover. | |
| 650 | 0 | |a Molecular biology. | |
| 650 | 2 | |a Molecular Biology |0 (DNLM)D008967 | |
| 650 | 6 | |a Biologie mol�eculaire. |0 (CaQQLa)201-0064024 | |
| 650 | 7 | |a molecular biology. |2 aat |0 (CStmoGRI)aat300054470 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Molecular biology |2 fast |0 (OCoLC)fst01024734 | |
| 700 | 1 | |a Teplow, David B., |e editor. | |
| 776 | 0 | 8 | |i Print version: |a Teplow, David B. |t Progress in Molecular Biology and Translational Science. |d San Diego : Elsevier Science & Technology, �2018 |z 9780128162354 |
| 830 | 0 | |a Progress in molecular biology and translational science ; |v 159. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/18771173/159 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128162354 |z Texto completo |