Cargando…
Fluorine in life sciences : pharmaceuticals, medicinal diagnostics, and agrochemicals /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom ; San Diego, CA :
Academic Press,
[2019]
|
| Colección: | Progress in fluorine science series.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- 4.3.1 Fluorination of the a-position of carbonyl compounds4.3.2 Electrophilic fluorination of enolates; 4.4 From carboxylic acids; 4.5 From diazo compounds/olefins; 5. Aromatic C-H fluorination; 5.1 Electrophilic aromatic fluorination; 5.2 Transition metal-catalyzed aromatic C-H fluorination; 6. Benzylic C-H fluorination; 6.1 Transition metal-catalyzed C-H fluorination; 6.2 Metal free-radical initiated fluorination; 6.3 Photocatalyzed C-H fluorination; 7. Fluorination of unactivated aliphatic C-H bonds; 7.1 Transition metal-catalyzed C-H fluorination; 7.2 Radical-initiated fluorination.
- Front Cover; Fluorine in Life Sciences:Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals; Fluorine in Life Sciences:Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals; Contents; List of contributors; About the editors; Preface; 1
- Emerging fluorination methods in organic chemistry relevant for life science application; 1. Introduction; 2. Common reagents; 2.1 Nucleophilic fluorination sources; 2.2 Electrophilic fluorination sources; 3. Fluorination of prefunctionalized aromatic/heteroaromatic substrates; 3.1 Balz-Schiemann reaction; 3.2 The Halex reaction.
- 3.3 Transition metal-catalyzed fluorination of aryl halides and pseudo-halides3.4 Aromatic deoxyfluorination: PhenoFluor/PhenoFluor Mix; 3.5 Decarboxylative fluorination of heterocycles; 3.6 Fluorination of aryl boron derivatives; 3.7 Fluorination of aryl stannanes; 3.8 Fluorination of aryl silanes; 3.9 Fluorination of diaryliodonium salts; 4. Fluorination of prefunctionalized aliphatic substrates; 4.1 Nucleophilic displacement of halides/activated alcohols; 4.2 Deoxyfluorination-a new era!; 4.3 Direct replacement from aldehydes/ketones.
- 7.3 Photocatalyzed fluorination of unactivated aliphatic C-H bonds8. Conclusions and outlook; References; 2
- Fluorination patterns in small alkyl groups: their impact on properties relevant to drug discovery; 1. Introduction; 2. Effective and intrinsic lipophilicity; 3. Basicity modulation by fluorine in aliphatic amines; 4. Modulation of lipophilicity by partially fluorinated alkyl groups; 5. Partially fluorinated alkyl groups attached to aryl carbon; 6. Partially fluorinated alkyl groups attached to ether oxygen; 7. Partially fluorinated alkyl groups attached to saturated amine nitrogen.
- 8. Aqueous solubility related to lipophilicity and crystal lattice energy9. In vitro oxidative metabolism related to lipophilicity; 10. Conclusions and outlook; References; 3
- Polyfluorinated scaffolds in drug discovery; 1. Introduction; 1.1 Properties of fluorine; 2. Fluorine chemistry and drug discovery; 2.1 Fluorinated natural products; 2.2 "Early" perfluoroalkyl group-containing compounds; 2.3 Metabolism and toxicity of polyfluorinated compounds; 3. Polyfluorinated drugs; 3.1 Central nervous system agents; 3.2 Anticancer agents; 3.3 Metabolic disorder agents.