|
|
|
|
| LEADER |
00000cam a2200000 i 4500 |
| 001 |
SCIDIR_on1055049972 |
| 003 |
OCoLC |
| 005 |
20231120010317.0 |
| 006 |
m o d |
| 007 |
cr cnu---unuuu |
| 008 |
180929s2019 enka ob 001 0 eng d |
| 040 |
|
|
|a EBLCP
|b eng
|e rda
|e pn
|c EBLCP
|d N$T
|d OPELS
|d N$T
|d YDX
|d OCLCF
|d OTZ
|d LVT
|d OCLCQ
|d D6H
|d YDXIT
|d UKMGB
|d LQU
|d ESU
|d OCLCQ
|d SNK
|d OCLCQ
|d S2H
|d OCLCO
|d VT2
|d OCLCQ
|d OCLCO
|d OCLCQ
|d OCLCA
|d OCLCO
|d K6U
|d OCLCQ
|d SFB
|d OCLCQ
|d OCLCO
|
| 066 |
|
|
|c (S
|
| 015 |
|
|
|a GBB978886
|2 bnb
|
| 016 |
7 |
|
|a 019066057
|2 Uk
|
| 019 |
|
|
|a 1054829672
|a 1098218012
|a 1155235042
|a 1235837329
|
| 020 |
|
|
|a 9780128127346
|q (electronic book)
|
| 020 |
|
|
|a 0128127341
|q (electronic book)
|
| 020 |
|
|
|z 9780128127339
|q (paperback)
|
| 020 |
|
|
|z 0128127333
|q (paperback)
|
| 035 |
|
|
|a (OCoLC)1055049972
|z (OCoLC)1054829672
|z (OCoLC)1098218012
|z (OCoLC)1155235042
|z (OCoLC)1235837329
|
| 050 |
|
4 |
|a QD181.F1
|b F58 2019
|
| 060 |
|
4 |
|a 2019 E-939
|
| 060 |
|
4 |
|a QV 282
|
| 072 |
|
7 |
|a SCI
|x 013030
|2 bisacsh
|
| 072 |
|
7 |
|a PNN
|2 bicssc
|
| 082 |
0 |
4 |
|a 546/.731
|2 23
|
| 245 |
0 |
0 |
|a Fluorine in life sciences :
|b pharmaceuticals, medicinal diagnostics, and agrochemicals /
|c edited by G�unter Haufe, Fr�ed�eric R. Leroux.
|
| 264 |
|
1 |
|a London, United Kingdom ;
|a San Diego, CA :
|b Academic Press,
|c [2019]
|
| 300 |
|
|
|a 1 online resource (xviii, 667 pages)
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Progress in fluorine science series
|
| 504 |
|
|
|a Includes bibliographical references and index.
|
| 505 |
8 |
|
|a 4.3.1 Fluorination of the a-position of carbonyl compounds4.3.2 Electrophilic fluorination of enolates; 4.4 From carboxylic acids; 4.5 From diazo compounds/olefins; 5. Aromatic C-H fluorination; 5.1 Electrophilic aromatic fluorination; 5.2 Transition metal-catalyzed aromatic C-H fluorination; 6. Benzylic C-H fluorination; 6.1 Transition metal-catalyzed C-H fluorination; 6.2 Metal free-radical initiated fluorination; 6.3 Photocatalyzed C-H fluorination; 7. Fluorination of unactivated aliphatic C-H bonds; 7.1 Transition metal-catalyzed C-H fluorination; 7.2 Radical-initiated fluorination.
|
| 505 |
0 |
|
|6 880-01
|a Front Cover; Fluorine in Life Sciences:Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals; Fluorine in Life Sciences:Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals; Contents; List of contributors; About the editors; Preface; 1 -- Emerging fluorination methods in organic chemistry relevant for life science application; 1. Introduction; 2. Common reagents; 2.1 Nucleophilic fluorination sources; 2.2 Electrophilic fluorination sources; 3. Fluorination of prefunctionalized aromatic/heteroaromatic substrates; 3.1 Balz-Schiemann reaction; 3.2 The Halex reaction.
|
| 505 |
8 |
|
|a 3.3 Transition metal-catalyzed fluorination of aryl halides and pseudo-halides3.4 Aromatic deoxyfluorination: PhenoFluor/PhenoFluor Mix; 3.5 Decarboxylative fluorination of heterocycles; 3.6 Fluorination of aryl boron derivatives; 3.7 Fluorination of aryl stannanes; 3.8 Fluorination of aryl silanes; 3.9 Fluorination of diaryliodonium salts; 4. Fluorination of prefunctionalized aliphatic substrates; 4.1 Nucleophilic displacement of halides/activated alcohols; 4.2 Deoxyfluorination-a new era!; 4.3 Direct replacement from aldehydes/ketones.
|
| 505 |
8 |
|
|a 7.3 Photocatalyzed fluorination of unactivated aliphatic C-H bonds8. Conclusions and outlook; References; 2 -- Fluorination patterns in small alkyl groups: their impact on properties relevant to drug discovery; 1. Introduction; 2. Effective and intrinsic lipophilicity; 3. Basicity modulation by fluorine in aliphatic amines; 4. Modulation of lipophilicity by partially fluorinated alkyl groups; 5. Partially fluorinated alkyl groups attached to aryl carbon; 6. Partially fluorinated alkyl groups attached to ether oxygen; 7. Partially fluorinated alkyl groups attached to saturated amine nitrogen.
|
| 505 |
8 |
|
|a 8. Aqueous solubility related to lipophilicity and crystal lattice energy9. In vitro oxidative metabolism related to lipophilicity; 10. Conclusions and outlook; References; 3 -- Polyfluorinated scaffolds in drug discovery; 1. Introduction; 1.1 Properties of fluorine; 2. Fluorine chemistry and drug discovery; 2.1 Fluorinated natural products; 2.2 "Early" perfluoroalkyl group-containing compounds; 2.3 Metabolism and toxicity of polyfluorinated compounds; 3. Polyfluorinated drugs; 3.1 Central nervous system agents; 3.2 Anticancer agents; 3.3 Metabolic disorder agents.
|
| 500 |
|
|
|a 3.3.1 Fenfluramine (1973, 70) and Tiflorex (Flutiorex, 71).
|
| 588 |
0 |
|
|a Online resource; title from digital title page (viewed on April 24, 2019).
|
| 650 |
|
0 |
|a Fluorine.
|
| 650 |
|
0 |
|a Fluorine
|x Physiological effect.
|
| 650 |
1 |
2 |
|a Fluorine
|x pharmacology
|0 (DNLM)D005461Q000494
|
| 650 |
|
2 |
|a Fluorine
|0 (DNLM)D005461
|
| 650 |
|
6 |
|a Fluor.
|0 (CaQQLa)201-0025981
|
| 650 |
|
6 |
|a Fluor
|x Effets physiologiques.
|0 (CaQQLa)201-0008917
|
| 650 |
|
7 |
|a SCIENCE
|x Chemistry
|x Inorganic.
|2 bisacsh
|
| 650 |
|
7 |
|a Fluorine
|2 fast
|0 (OCoLC)fst00928151
|
| 650 |
|
7 |
|a Fluorine
|x Physiological effect
|2 fast
|0 (OCoLC)fst00928157
|
| 700 |
1 |
|
|a Haufe, G�unter,
|e editor.
|
| 700 |
1 |
|
|a Leroux, Frederic,
|e editor.
|
| 776 |
0 |
8 |
|i Print version:
|a Haufe, G�unter.
|t Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals.
|d San Diego : Elsevier Science & Technology, �2018
|z 9780128127339
|
| 830 |
|
0 |
|a Progress in fluorine science series.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128127339
|z Texto completo
|
| 880 |
0 |
|
|6 505-01/(S
|a 4.3.1 Fluorination of the α-position of carbonyl compounds4.3.2 Electrophilic fluorination of enolates; 4.4 From carboxylic acids; 4.5 From diazo compounds/olefins; 5. Aromatic C-H fluorination; 5.1 Electrophilic aromatic fluorination; 5.2 Transition metal-catalyzed aromatic C-H fluorination; 6. Benzylic C-H fluorination; 6.1 Transition metal-catalyzed C-H fluorination; 6.2 Metal free-radical initiated fluorination; 6.3 Photocatalyzed C-H fluorination; 7. Fluorination of unactivated aliphatic C-H bonds; 7.1 Transition metal-catalyzed C-H fluorination; 7.2 Radical-initiated fluorination.
|
