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Advanced issue resolution in safety pharmacology /
Chapter 7. Self-Injurious Behavior in Clinical and Preclinical Populations: Description, Etiology, and Management; Introduction; Self-Injurious Behavior Overview; Self-Injurious Behavior in Nonhuman Experimental Subjects; Summary; Chapter 8. Approaches for Early Identification of Abuse Potential Lia...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press, an imprint of Elsevier,
[2019]
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Advanced issue resolution in safety pharmacology / |c edited by Mary Jeanne Kallman, Michael K. Pugsley. |
| 264 | 1 | |a London, United Kingdom : |b Academic Press, an imprint of Elsevier, |c [2019] | |
| 300 | |a 1 online resource | ||
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| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed September 18, 2018). | |
| 505 | 0 | |a Intro; Title page; Table of Contents; Copyright; List of Contributors; Chapter 1. Introduction to Issue Resolution; Chapter 2. Selection of Nontraditional Species for Issue Resolution Studies; Species Selection for Nonclinical Safety Pharmacology Studies; Species Considerations for Testing of Specific Organ Systems; Species Considerations for Testing of Biopharmaceuticals; Conclusion; Chapter 3. The Use of Modeling to Facilitate Decision-Making in Safety Pharmacology Assessments; What Are Models?; The Spectrum and Scale of Pharmacokinetic and Pharmacodynamic Models; Conclusions | |
| 505 | 8 | |a Chapter 4. Issue Resolution of Drug-Induced Breathing Instability and the Occurrence of Apneic EventsIntroduction to Breathing Instability; Issues Associated With Breathing Instability; Resolution of the Drug-Induced Breathing Instability Issue; Chapter 5. The Impact of Drug-Induced Effects on the Gastrointestinal System: Challenges and Issue Resolution for Safety Pharmacology; Introduction; Common Gastrointestinal Effects in Nonclinical Safety Evaluations; Potential Impact of Gastrointestinal Effects on Core Safety Pharmacology Organ Systems; Mitigation Strategies | |
| 505 | 8 | |a Conclusions and Future DirectionsFootnotes; Chapter 6. Sleep and Sleep Disruption; The Importance of Sleep; Measuring Sleep; Sleep Stages; Translatability of Electroencephalography in Sleep; Electroencephalography Frequencies; REM, Non-REM, and Wakefulness as a Translatable Biomarker; Changes in Sleep Patterns With Aging; Nondrug Disruption of Sleep; Drug-Induced Sleep Deprivation; Rapid Eye Movement Suppression; General Sleep Disturbances; Models of Sleep Disturbance; Circadian Rhythms; Using Genetic Models to Target Sleep Disruption and Normalize Sleep; Disruption of Sleep in Disease States | |
| 505 | 8 | |a Chapter 9. Issue Resolution of Motor Deficits and StereotypiesRodents; Nonhuman Primates; Preclinical Screening; Conclusion; Chapter 10. Issue Resolution Related to Convulsive Profiles; Introduction; Determining the Biological Plausibility of a Drug Producing a Convulsion; Assessing the Risk of Convulsants; Managing the Risk of Drug-Induced Convulsions and Seizures; Using Nonclincal Data to Determine Safe Clinical Exposure Levels; Discussion; Chapter 11. Utility of Progressive Ratio Schedules of Reinforcement in Abuse Potential Assessments; Introduction; Study Design Considerations | |
| 520 | |a Chapter 7. Self-Injurious Behavior in Clinical and Preclinical Populations: Description, Etiology, and Management; Introduction; Self-Injurious Behavior Overview; Self-Injurious Behavior in Nonhuman Experimental Subjects; Summary; Chapter 8. Approaches for Early Identification of Abuse Potential Liability; Introduction; Which Compounds Present an Issue for Preclinical Drug Abuse Liability Assessment?; An Integrated Approach for Assessment of Drug Abuse Liability; Examples of Abuse Liability Issue Resolution; Summary and Conclusions | ||
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| 700 | 1 | |a Kallman, Mary Jeanne, |e editor. | |
| 700 | 1 | |a Pugsley, Michael K., |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Advanced issue resolution in safety pharmacology. |d London, United Kingdom : Academic Press, an imprint of Elsevier, [2019] |z 0128122064 |z 9780128122068 |w (OCoLC)1020030129 |
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