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Risk assessment for human metal exposures : mode of action and kinetic approaches /
Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respe...
| Clasificación: | Libro Electrónico |
|---|---|
| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
2018.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; RISK ASSESSMENT FOR HUMAN METAL EXPOSURES; RISK ASSESSMENT FOR HUMAN METAL EXPOSURES: Mode of Action and Kinetic Approaches; Copyright; DEDICATION; CONTENTS; AUTHOR BIOGRAPHIES; PREFACE; One
- Metal Exposures and Human Health-Historical Development, Current Importance, and Toxicological Concepts for P ... ; 1.1 INTRODUCTION; 1.2 WIDESPREAD EXPOSURE TO METALS CONTRIBUTES TO GLOBAL BURDEN OF DISEASE; 1.3 METAL POISONING-CLINICAL SYMPTOMS AND SIGNS IN OCCUPATIONAL AND ENVIRONMENTAL SETTINGS
- 1.4 DETAILED INVESTIGATION IS REQUIRED FOR IDENTIFICATION OF ADVERSE EFFECTS AT LOW-LEVEL METAL EXPOSURES1.5 PERSPECTIVES ON HISTORICAL DEVELOPMENT OF CONCEPTS USED IN RISK ASSESSMENT OF METAL EXPOSURES-ROLE OF THE SCIENTIFIC COMMIT ... ; 1.6 CURRENT LONG-TERM LOW-LEVEL EXPOSURES AND RELATED HEALTH EFFECTS; 1.6.1 Neurotoxicology of Metals; 1.6.2 Cardiovascular Disease Related to Metals; 1.6.3 Kidney Effects of Exposure to Metals; 1.6.4 Cancer Induced by Metal Exposures; 1.6.5 Reproductive and Developmental Effects of Metal Exposures
- 1.7 ISSUES OF CURRENT CONCERN FOR HAZARD ASSESSMENT, RISK ASSESSMENT, AND PREVENTION1.7.1 Expanding Global Industrial Use of Metals; 1.7.2 Toxicity of Metallic Nanoparticles; 1.7.3 Environmental Mobilization Processes; 1.7.4 Toxic Metals in Food and Oral Intake; Other Intake Routes; 1.7.5 Metal Exposure by Release From Implanted Medical Devices; 1.7.6 Toxicokinetics and Dosimetry; 1.7.7 Essential Metals: Deficiency and Toxicity; 1.7.8 Biological Monitoring; 1.7.9 Interactions Among Metals and Gene-Environment Interactions
- 1.7.10 Application of MOA TKTD Models, AOPs, or Other Systems Toxicology Approaches to Risk and Hazard Assessment of Metal Exposures1.7.11 Applied Hazard- and Risk Assessment-Preventive Action and Management; REFERENCES; Two
- Exposure, Internal Dose, and Toxicokinetics (TK); 2.1 INTRODUCTION; TERMINOLOGY; 2.2 EXPOSURE; 2.2.1 General Considerations; 2.2.2 Exposure Through Food and Drinking Water; 2.2.3 Exposure by Inhalation; 2.3 DEPOSITION AND ABSORPTION; 2.3.1 General Considerations Including an Introduction to Skin Deposition; 2.3.2 Deposition and Absorption After Ingestion
- 2.3.3 Deposition and Absorption After Inhalation2.3.3.1 Deposition and Absorption of Gases and Vapors; 2.3.3.2 Deposition of Particles; 2.3.3.3 Clearance of Particles From the Respiratory System; 2.3.3.3.1 Tracheobronchial Clearance; 2.3.3.3.2 Peripheral Lung Clearance and Translocation From the Respiratory Tract; 2.3.4 Total Absorption; 2.4 TRANSPORT, BIOTRANSFORMATION, AND DISTRIBUTION; 2.5 EXCRETION; 2.5.1 Gastrointestinal Excretion; 2.5.2 Excretion Through the Kidneys; 2.5.3 Excretion Rate: Biological Half-Life (Half-Time); 2.6 TOXICOKINETIC MODELS; 2.6.1 One-Compartment Model