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019 |a 1048280566  |a 1048443775  |a 1049603516 
020 |a 9780128125939  |q electronic book 
020 |a 0128125934  |q electronic book 
020 |z 9780128125922 
020 |z 0128125926 
035 |a (OCoLC)1047959804  |z (OCoLC)1048280566  |z (OCoLC)1048443775  |z (OCoLC)1049603516 
050 4 |a RC455.4.G4  |b N48 2018 
060 4 |a WM 140  |b .N48 2018 
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072 7 |a MED  |x 014000  |2 bisacsh 
072 7 |a MED  |x 022000  |2 bisacsh 
072 7 |a MED  |x 112000  |2 bisacsh 
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072 7 |a PSD  |2 bicssc 
082 0 4 |a 616.89/042  |2 23 
245 0 0 |a Neuroepigenetics and mental illness /  |c edited by Bart P.F. Rutten. 
264 1 |a Cambridge, MA :  |b Academic Press, an imprint of Elsevier,  |c [2018] 
264 4 |c �2018 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Progress in molecular biology and translational science ;  |v volume one hundred and fifty eight 
504 |a Includes bibliographical references and index. 
588 0 |a Online resource; title from PDF title page ( viewed August 08, 2018). 
505 0 |a Front Cover; Neuroepigenetics and Mental Illness; Copyright; Contents; Contributors; Chapter One: Neuroepigenetics of Mental Illness: The Inside Outs of the Outside Within; 1. The Epigenetic Machinery; 2. The Nature of Mental Disorders; 2.1. Complexity of Developmental Programming and the Brain; 2.2. Complexity of Dynamic, Rather Than Static, Concepts of Mental Illness; 3. An Integrative and Dynamic Conceptual Model; 4. Future Perspectives; References; Chapter Two: Methodologies of Neuroepigenetic Research: Background, Challenges and Future Perspectives; 1. Introduction 
505 8 |a 2. Methodologies of Neuroepigenetic Research2.1. DNA Methylation and Hydroxymethylation; 2.2. Histone Modifications; 2.3. Non-Coding RNAs; 3. Challenges and Future Perspectives; 3.1. Technological Issues; 3.2. Tissue and Cell-Type Specificity; 3.3. Causality; 3.4. Study Design; 3.5. Analytical Techniques; 4. Conclusion; References; Chapter Three: An Introduction to Epigenetic Mechanisms; 1. Introduction; 1.1. Epigenetic Mechanisms and Neurodevelopment; 2. Epigenetic Mechanisms of Regulation; 2.1. DNA Methylation; 2.1.1. DNA Methylation and Transcriptional Control; 2.2. DNA Hydroxymethylation 
505 8 |a 2.3. Histone Modifications2.4. Non-coding RNA; 3. Genomic Imprinting; 4. Reprogramming of Epigenetic Marks During Development; 4.1. Histone Modifications and Epigenetic Reprogramming; 4.2. Reprogramming of DNA Methylation; 5. Epigenetic Inheritance; 6. Concluding Remarks; Acknowledgment; References; Chapter Four: Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders; 1. Neuroepigenetics of Aging; 1.1. Alterations in DNA Modifications With Age; 1.2. Alterations in Chromatin Modifications During Aging; 1.3. Changes in Non-Coding RNAs 
505 8 |a 2. Neuroepigenetics of Age-Related Neurodegenerative Disorders2.1. Epigenetic Alterations in Alzheimer's Disease; 2.1.1. AD-Related DNA Modifications; 2.1.2. AD-Related Chromatin Modifications; 2.1.3. Alterations in Non-Coding RNAs in AD; 2.2. Epigenetic Alterations in Parkinson's Disease; 2.2.1. Alterations in DNA Modifications in PD; 2.2.2. Alterations in Chromatin Modifications in PD; 2.2.3. Alterations in Non-Coding RNAs in PD; 2.3. Epigenetic Alterations in Huntington's Disease; 2.3.1. Changes in DNA Modifications in HD; 2.3.2. Changes in Chromatin Modifications in HD 
505 8 |a 2.3.3. Changes in Non-Coding RNAs in HD3. Concluding Remarks; References; Chapter Five: Neuroepigenetics of Prenatal Psychological Stress; 1. Introduction; 1.1. The DOHaD Hypothesis; 1.2. Maternal Psychological Stress; 2. The Consequences of Prenatal Psychological Stress; 2.1. Animal Studies; 2.2. Human Studies; 2.2.1. Prenatal Stress and Internalizing Psychopathology; 2.2.2. Prenatal Stress and Externalizing Psychopathology; 2.2.3. Prenatal Stress and Other Mental Disorders; 2.2.4. Underlying Endophenotypes and Neurobiological System Changes 
650 0 |a Mental illness  |x Genetic aspects. 
650 0 |a Mental illness  |x Physiological aspects. 
650 0 |a Neurogenetics. 
650 0 |a Epigenetics. 
650 6 |a Maladies mentales  |x Aspect g�en�etique.  |0 (CaQQLa)201-0012332 
650 6 |a Maladies mentales  |x Aspect physiologique.  |0 (CaQQLa)201-0012330 
650 6 |a Neurog�en�etique.  |0 (CaQQLa)201-0102990 
650 6 |a �Epig�en�etique.  |0 (CaQQLa)000270630 
650 7 |a HEALTH & FITNESS  |x Diseases  |x General.  |2 bisacsh 
650 7 |a MEDICAL  |x Clinical Medicine.  |2 bisacsh 
650 7 |a MEDICAL  |x Diseases.  |2 bisacsh 
650 7 |a MEDICAL  |x Evidence-Based Medicine.  |2 bisacsh 
650 7 |a MEDICAL  |x Internal Medicine.  |2 bisacsh 
650 7 |a Epigenetics  |2 fast  |0 (OCoLC)fst01893642 
650 7 |a Mental illness  |x Genetic aspects  |2 fast  |0 (OCoLC)fst01016576 
650 7 |a Mental illness  |x Physiological aspects  |2 fast  |0 (OCoLC)fst01016587 
650 7 |a Neurogenetics  |2 fast  |0 (OCoLC)fst01036353 
700 1 |a Rutten, Bart P. F.,  |e editor. 
776 0 8 |i Print version:  |t Neuroepigenetics and mental illness.  |d Cambridge, MA : Academic Press, an imprint of Elsevier, [2018]  |z 0128125926  |z 9780128125922  |w (OCoLC)1020030080 
830 0 |a Progress in molecular biology and translational science ;  |v v. 158. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/18771173/158  |z Texto completo