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Sphingolipids in cancer /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
2018.
|
| Colección: | Advances in cancer research ;
v. 140. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 001 | SCIDIR_on1046977686 | ||
| 003 | OCoLC | ||
| 005 | 20231120010308.0 | ||
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| 008 | 180801s2018 enk ob 000 0 eng d | ||
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| 245 | 0 | 0 | |a Sphingolipids in cancer / |c edited by Charles E. Chalfant, Paul B. Fisher. |
| 264 | 1 | |a London : |b Academic Press, |c 2018. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in cancer research, |x 0065-230X ; |v v. 140 | |
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed August 2, 2018). | |
| 505 | 0 | |a Front Cover; Advances in Cancer Research; Advances in Cancer Research:Sphingolipids in Cancer; Contents; CONTRIBUTORS; FOREWORD; PREFACE; One -- Mechanisms of Ceramide-Dependent Cancer Cell Death; 1. INTRODUCTION; 2. SPHINGOLIPID METABOLISM AND CANCER; 2.1 Structure and Metabolism of Sphingolipids; 2.2 Enzymes of Ceramide Metabolism and Cancer; 2.2.1 Serine Palmitoyltransferase; 2.2.2 Ceramide Synthases 1-6; 2.2.3 Dihydroceramide Desaturase (DES or DEGS1); 2.2.4 Sphingomyelinases; 2.2.5 Sphingomyelin Synthases and Ceramide Transporter; 2.2.6 Ceramide Kinase; 2.2.7 Glucosylceramide Synthase | |
| 505 | 8 | |a 2.2.8 Ceramidases3. CERAMIDE IN CANCER CELL DEATH; 3.1 Ceramide and Apoptosis; 3.2 Ceramide and Necroptosis; 3.3 Ceramide and Lethal Autophagy or Mitophagy; 3.4 Ceramide and Endoplasmic Reticulum Stress; 3.5 Ceramide and Cell Cycle Arrest; 4. SPHINGOLIPID METABOLISM AND ANTICANCER THERAPY; 4.1 Ceramide Generation in the Induction of Chemotherapy/Radiation-Mediated Tumor Suppression; 4.2 Ceramide Metabolism in Tumor Immunology and Immunotherapy; 4.2.1 Targeting Sphingolipid Metabolism and Signaling for Cancer Therapy; 5. DISCUSSION; ACKNOWLEDGMENTS; REFERENCES; FURTHER READING | |
| 505 | 8 | |a Two -- Sphingolipids as Regulators of Autophagy and Endocytic Trafficking1. INTRODUCTION; 2. THE MOLECULAR MACHINERY OF AUTOPHAGY AND REGULATION BY SPHINGOLIPIDS; 2.1 Autophagy Initiation: the Unc-51-Like Kinase Complex; 2.1.1 Sphingolipids in Autophagy Initiation; 2.2 Phagophore Nucleation: the Phosphatidylinositol 3-Kinase Complex; 2.2.1 Sphingolipids in Phagophore Nucleation; 2.3 Phagophore Elongation: LC3 Lipidation; 2.3.1 Sphingolipid-Mediated Regulation of LC3 Lipidation; 2.4 Phagophore Elongation: Membrane Delivery and Autophagic Cargo | |
| 505 | 8 | |a 2.4.1 Sphingolipid Regulation of Membrane Delivery and Autophagic Cargo2.5 Phagophore Closure; 2.6 Autophagosome-Lysosome Fusion; 2.6.1 Sphingolipids in Autophagosome Maturation; 3. SPHINGOLIPID-MEDIATED AUTOPHAGY IN CANCER: DR. JEKYLL AND MR. HYDE; 3.1 Dr. Jekyll: A Driver of Cancer Cell Survival; 3.2 Mr. Hyde: Inducer of Autophagy-Dependent Cancer Cell Death; 3.2.1 Lethal Mitophagy; 3.2.2 Autophagic Cell Death by Noncanonical Autophagy; 3.2.3 Autophagy-Dependent Lysosomal Membrane Permeabilization; 3.2.4 Autophagy-Dependent Noncanonical Caspase-8 Activation | |
| 505 | 8 | |a 3.2.5 Autophagy-Dependent Apoptosis via the Calpain-Mediated Cleavage of ATG54. CONCLUSION AND FUTURE DIRECTIONS; REFERENCES; Three -- Role and Function of Sphingomyelin Biosynthesis in the Development of Cancer; 1. STRUCTURE AND INTRACELLULAR DISTRIBUTION OF SPHINGOMYELIN; 2. THE SPHINGOMYELIN SYNTHASE ENZYMES; 3. FUNCTIONS OF THE LIPIDS REGULATED BY THE SPHINGOMYELIN SYNTHASE REACTION; 3.1 Sphingomyelin; 3.1.1 Regulation of Lipid Microdomains in the Outer Leaflet of the Plasma Membrane and Impact on Receptor-Mediated Signaling | |
| 504 | |a Includes bibliographical references. | ||
| 650 | 0 | |a Sphingolipids. | |
| 650 | 2 | |a Neoplasms |0 (DNLM)D009369 | |
| 650 | 2 | |a Sphingolipids |0 (DNLM)D013107 | |
| 650 | 6 | |a Sphingolipides. |0 (CaQQLa)201-0086675 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Sphingolipids |2 fast |0 (OCoLC)fst01129699 | |
| 655 | 4 | |a Internet Resources. | |
| 655 | 4 | |a Index not Present. | |
| 700 | 1 | |a Chalfant, Charles, |d 1970- |e editor. | |
| 700 | 1 | |a Fisher, Paul B., |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Sphingolipids in cancer. |d London : Academic Press, 2018 |z 0128142235 |z 9780128142233 |w (OCoLC)1020030438 |
| 830 | 0 | |a Advances in cancer research ; |v v. 140. |x 0065-230X | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/0065230X/140 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128142233 |z Texto completo |