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Reproductomics : the --omics revolution and its impact on human reproductive medicine /
Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The -Omics Revolution and Its Impact on Human Reproductive Medicine demon...
| Clasificación: | Libro Electrónico |
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| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Academic Press, an imprint of Elsevier,
2018.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Reproductomics: The -Omics Revolution and Its Impact on Human Reproductive Medicine; Copyright; Contents; Contributors; Preface; Introduction: Human Genome Projects: The Omics Starting Point; Preomics Era; Omics Era; Omics in the Assisted Reproduction Era; Genomics; Prenatal; Transcriptomics; Proteomics and Metabolomics; References; Chapter 1: Is the Classic Spermiogram Still Informative? How Did It Develop and Where Is It Going?; Introduction; Specific Aspects of Basic Semen Analysis; Semen Volume; Estimation of Sperm Concentration; Sperm Motility
- The Biological Relevance of Sperm MotilitySperm Morphology Analysis; Plasma Membrane Integrity; Conclusions; References; Chapter 2: Genetic Variations and Male Infertility; Introduction; Single Nucleotide Polymorphisms; MTHFR Gene Polymorphisms; DAZL and DAZ Genes Polymorphisms; BRDT Gene Polymorphisms; TERT and TEP1 Genes; Cytochrome P4501A1; FSHR Gene Polymorphisms; ESR1 and ESR2 Gene Polymorphisms; PRM1 and PRM2 Genes Polymorphisms; Insertion Deletion Polymorphisms; POLG Gene Polymorphisms; AR Gene Polymorphisms; Copy Number Variations; Y Chromosome Microdeletions
- Genome-Wide Association StudiesLimitations of Genetic Association Studies; Conclusion; References; Further Reading; Chapter 3: New Genetic Point Mutations in Male Infertility; Introduction; Genes and Male Factor Infertility; Male Sexual Differentiation Disorders and Gonadal Development Impairment; Spermatogenesis Alterations and Sperm Function Impairment; Single-Nucleotide Polymorphism; Final Comments; References; Chapter 4: Carrier Screening for Inherited Genetic Disorders: A Review of Current Practices; Introduction to Genetics; Genetic Disease and Inheritance
- Introduction to Carrier ScreeningGuidelines for Carrier Screening; Carrier Screening Technologies; CBC and Hemoglobin Electrophoresis; HEXA (Tay-Sachs) Enzyme Analysis; Fragile X Syndrome-CGG and AGG Analysis; Spinal Muscular Atrophy (SMA) Dosage Analysis; Carrier Rates, Detection Rates, and Residual Risks; Reproductive Options for High-Risk Couples; Further Reading; Chapter 5: Telomeres in Germ Line and Early Embryo: An Overview; Historical Landmarks; Structure of Telomeres; Telomere Physiology; Telomeres in Aging and Age-Related Disease; Telomeres in Male Germ Line
- Telomeres in Female Germ LineTelomeres in Early Embryo; Concluding Considerations; Acknowledgments; References; Chapter 6: Human Protamine Genes' Polymorphisms as a Possible Cause Underlying Male Infertility; Introduction; Protamine Structure and Functions; Protamine Genes Organization; PRM1/PRM2 Ratio; Protamine 1 Gene Polymorphisms; Polymorphisms in the Promoter Region; Polymorphisms in the Coding Region; Polymorphisms in the 32 Noncodifying Region; Protamine 2 Gene Polymorphisms; Polymorphisms in the Promoter Region; Polymorphisms in the Coding Region