|
|
|
|
| LEADER |
00000cam a2200000 i 4500 |
| 001 |
SCIDIR_on1031373801 |
| 003 |
OCoLC |
| 005 |
20231120010251.0 |
| 006 |
m o d |
| 007 |
cr cnu|||unuuu |
| 008 |
180416s2018 enk o 001 0 eng d |
| 040 |
|
|
|a N$T
|b eng
|e rda
|e pn
|c N$T
|d N$T
|d OPELS
|d EBLCP
|d NLE
|d NRC
|d OCLCF
|d STF
|d MERER
|d D6H
|d OCLCQ
|d U3W
|d LVT
|d YDX
|d OCLCQ
|d S2H
|d OCLCO
|d UX1
|d OCLCQ
|d OCLCO
|d K6U
|d OCLCQ
|d CASUM
|d OCLCO
|
| 020 |
|
|
|a 9780128113547
|q (electronic bk.)
|
| 020 |
|
|
|a 0128113545
|q (electronic bk.)
|
| 020 |
|
|
|z 9780128113530
|
| 035 |
|
|
|a (OCoLC)1031373801
|
| 050 |
|
4 |
|a QP86
|
| 060 |
|
4 |
|a 2019 D-542
|
| 060 |
|
4 |
|a WT 104
|
| 072 |
|
7 |
|a MED
|x 075000
|2 bisacsh
|
| 072 |
|
7 |
|a SCI
|x 036000
|2 bisacsh
|
| 072 |
|
7 |
|a MJX
|2 bicssc
|
| 082 |
0 |
4 |
|a 612.6/7
|2 23
|
| 245 |
0 |
0 |
|a Conn's handbook of models for human aging /
|c editors, Jeffrey L. Ram, P. Michael Conn.
|
| 250 |
|
|
|a Second edition.
|
| 264 |
|
1 |
|a London, United Kingdom :
|b Elsevier Ltd. :
|b Academic Press,
|c [2018]
|
| 300 |
|
|
|a 1 online resource
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 588 |
|
|
|a Online resource; title from PDF title page (EBSCO, viewed April 17, 2018).
|
| 500 |
|
|
|a Includes index.
|
| 505 |
0 |
|
|a Intro; Title page; Table of Contents; Copyright; List of Contributors; Preface; Preface; Section I. Aging in Humans; Chapter 1. Werner Syndrome as a Model of Human Aging; Introduction and Historical Overview; Werner Syndrome as a Clinical Disease; Cancer in Werner Syndrome; Clinical Progression of Werner Syndrome; Diagnostic Criteria and Differential Diagnosis; The WRN Gene and Disease-Associated Mutations; Atypical WS/Other Heritable Progeroid Syndromes Distinct From WS; WRN Protein Function in Human Cells; The Relationship of Werner Syndrome to Normal Aging.
|
| 505 |
8 |
|
|a Experimental Models of Werner SyndromePotential Therapeutic Targets and Strategies; Concluding Remarks; Print Resources; Web Resources; Chapter 2. Premature Aging Syndrome; Introduction; Hutchinson-Gilford Progeria and Werner Syndrome; Causative Genes and Molecular Mechanisms; Management and Therapeutic Approaches; Cell Culture Models; Mouse Models; Conclusions; Chapter 3. Models, Definitions, and Criteria for Frailty; Introduction; Models and Mechanisms; Definition; Criteria; Conclusion; Recommended Resources.
|
| 505 |
8 |
|
|a Chapter 4. Immunological Methods and the Concept of Inflammaging in the Study of Human AgingIntroduction; Phenotypic Analyses; Functional Analyses; Inflammaging; A Dysregulatory Approach Integrating the Immune System and Other Systems; Conclusion; Chapter 5. Vulnerability and Experiential Health in Old Age-A Qualitative Perspective; Introduction; Aging in the World of Meanings; Qualitative Methods as the Study of Meanings; The Meaning and Experience of Vulnerability in Old Age; Experiential Health in Old Age; Researching Subjectivity-Comments on Research Ethics.
|
| 505 |
8 |
|
|a Chapter 6. Body Composition in Older AdultsIntroduction; Overview and Understanding of Body Composition and Compartments; Aging-Related Changes in Body Composition; Measurement of Aging-Related Changes in Body Composition in Clinical Practice; Chapter 7. Using Computational Models to Study Aging; Introduction; The Interconnected Nature of Aging; Why Computational Models Are Needed to Study Health Span?; What Is a Computational Model?; The Steps Involved in Building a Computer Model; Mathematical Frameworks; Modeling Software and Modeling Standards.
|
| 505 |
8 |
|
|a Computational Modeling of Intracellular ProcessesModeling Nutrient Focused Cellular Pathways; Whole Body Models and Health Span; Opportunities and Future Challenges; Conclusions; Chapter 8. A Framework for Uncovering the Roles of Calories and Macronutrients in Health and Aging; Introduction; Calorie Restriction; Invertebrate Models; Mammalian Models; Calorie Restriction: Is It Plausible for Humans?; Studies of Protein and Amino Acid Restriction; Limitations of Single-Nutrient Manipulation Approaches; The Geometric Framework; Geometric Designs for Aging Research; From Insects to Mice.
|
| 650 |
|
0 |
|a Aging.
|
| 650 |
|
0 |
|a Aging
|x Animal models.
|
| 650 |
|
0 |
|a Diseases
|x Animal models.
|
| 650 |
|
0 |
|a Aging
|x Genetic aspects.
|
| 650 |
|
2 |
|a Aging
|0 (DNLM)D000375
|
| 650 |
|
2 |
|a Disease Models, Animal
|0 (DNLM)D004195
|
| 650 |
|
6 |
|a Vieillissement.
|0 (CaQQLa)201-0020292
|
| 650 |
|
6 |
|a Vieillissement
|x Mod�eles animaux.
|0 (CaQQLa)201-0217315
|
| 650 |
|
6 |
|a Maladies
|x Mod�eles animaux.
|0 (CaQQLa)201-0067878
|
| 650 |
|
6 |
|a Vieillissement
|x Aspect g�en�etique.
|0 (CaQQLa)201-0104236
|
| 650 |
|
7 |
|a MEDICAL
|x Physiology.
|2 bisacsh
|
| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Human Anatomy & Physiology.
|2 bisacsh
|
| 650 |
|
7 |
|a Aging
|2 fast
|0 (OCoLC)fst00800293
|
| 650 |
|
7 |
|a Aging
|x Animal models
|2 fast
|0 (OCoLC)fst00800294
|
| 650 |
|
7 |
|a Aging
|x Genetic aspects
|2 fast
|0 (OCoLC)fst00800307
|
| 650 |
|
7 |
|a Diseases
|x Animal models
|2 fast
|0 (OCoLC)fst00895160
|
| 655 |
|
4 |
|a Internet Resources.
|
| 700 |
1 |
|
|a Ram, Jeffrey L.,
|e editor.
|
| 700 |
1 |
|
|a Conn, P. Michael,
|e editor.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128113530
|z Texto completo
|
