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The molecular and cellular basis of neurodegenerative diseases : underlying mechanisms /
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prio...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press is an imprint of Elsevier,
[2018]
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 060 | 4 | |a 2018 E-882 | |
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| 082 | 0 | 4 | |a 616.80442 |2 23 |
| 245 | 0 | 4 | |a The molecular and cellular basis of neurodegenerative diseases : |b underlying mechanisms / |c edited by Michael S. Wolfe. |
| 264 | 1 | |a London : |b Academic Press is an imprint of Elsevier, |c [2018] | |
| 264 | 4 | |c �2018 | |
| 300 | |a 1 online resource (xiv, 545 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Online resource; title from PDF title page (EBSCO, viewed April 6, 2018). | |
| 505 | 0 | |a Solving the puzzle of neurodegeneration / Michael S. Wolfe -- Prion diseases / Robert C.C. Mercer, Alex J. McDonald, Erin Bove-Fenderson, Cheng Fang, Bei Wu and David A. Harris -- Alzheimer's Disease: toward a quantitative biological approach in describing its natural history and underlying mechanisms / Colin L. Masters, Ben Gu, Simon Laws, Yen Y Lim, Blaine Roberts, Victor L. Villemagne and Konrad Beyreuther | |
| 505 | 0 | |a Neurodegeneration and the ordered assembly of tau / Michel Goedert -- Amyotrophic lateral sclerosis and other TDP-43 proteinopathies / Jorge Gomez-Deza and Christopher E. Shaw -- Parkinson's disease and other synucleinopathies / Mark R. Cookson -- Huntington's disease and other polyglutamine repeat diseases: molecular mechanisms and pathogenic pathways / Audrey S. Dickey and Albert R. La Spada | |
| 505 | 0 | |a Prion-like propagation in neurogenerative diseases / Wouter Peelaerts, Veerle Baekelandt and Patrik Brundin -- Neurodegenerative diseases as protein folding disorders / Jermey D. Baker, Jack M. Webster, Lindsey B. Shelton, John Koren, III, Vladimir N. Uversky, Laura J. Blair and Chad A. Dickey -- Heat shock proteins and protein quality control in Alzheimer's disease / Fred W. Van Leeuwen and Harm H. Kampinga -- Neurodegenerative diseases and autophagy / Angeleen Fleming, Mariella Vicinanza, Maurizio Renna, Claudia Puri, Thomas Ricketts, Jens F�ullgrabe, Ana Lopez, Sarah M. De Jager, Avraham Ashkenazi, Mariana Pavel, Floriana Licitra, Andrea Caricasole, Stephen P. Andrews, John Skidmore and David C. Rubinsztein -- Neurodegenerative Diseases and axonal transport / Lawrence S. Goldstein and Utpal Das -- Mitochondrial function and neurodegenerative diseases / Heather M. Wilkins, Ian Weidling, Scott Koppel, Xiaowan Wang, Alex Von Schulze and Russell H. Swerdlow | |
| 505 | 0 | |a Non-cell autonomous degeneration: role of astrocytes in neurodegenerative diseases / Sarah E. Smith and Azad Bonni -- Neurodegenerative diseases and RNA-mediated toxicity / Tiffany W. Todd and Leonard Petrucelli -- Neuroinflammation in are-related neurodegenerative diseases / Kathryn P. MacPherson, Maria E. De Sousa Rodrigues, Amarallys F. Cintron and Mal�u G. Tansey -- Neurodegenerative diseases and the aging brain / Stephen K. Godin, Jinsoo Seo and Li-Huei Tsai -- Index. | |
| 520 | |a The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. | ||
| 650 | 0 | |a Nervous system |x Degeneration |x Molecular aspects. | |
| 650 | 1 | 2 | |a Neurodegenerative Diseases |x microbiology |0 (DNLM)D019636Q000382 |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Nervous system |x Degeneration |x Molecular aspects |2 fast |0 (OCoLC)fst01036094 | |
| 655 | 4 | |a Internet Resources. | |
| 700 | 1 | |a Wolfe, Michael S., |e editor. | |
| 776 | 0 | 8 | |t Molecular and cellular basis of neurodegenerative diseases. |d London : Academic Press is an imprint of Elsevier, [2018] |z 9780128113042 |w (OCoLC)1040033113 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128113042 |z Texto completo |
| 880 | 8 | |6 505-00/(S |a Molecular Mechanism of Prion PropagationThe Cellular Prion Protein: Structure and Proteolytic Processing; Physiological Function of PrPC; Mechanisms of PrPSc Toxicity: The N-Terminal Domain of PrPC Possess a Toxic Effector Activity; Human Prion Diseases; Animal Prion Diseases; Prion Strains and Species Barriers; Methods for Propagation and Detection of Prions; Therapeutic Approaches; PrPC and the Alzheimer's Aβ Peptide; Prion-like Propagation of Misfolded Proteins in Other Neurodegenerative Diseases; Concluding Remarks; References | |
| 880 | 8 | |6 505-00/(S |a 3 Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying MechanismsQuantitative Approach to Basic AD Demographics; Change Over Time: (i) Biogenesis, Production, and Turnover of Aβ; Change Over Time: (ii) The Accumulation, Spread, Propagation of Aβ; Change Over Time: (iii) The Growth and Accumulation of Plaque Cores; Change Over Time: (iv) Brain Atrophy; Change Over Time: (v) Cognition; Clearance Mechanisms and Impaired Phagocytosis; Calculating Polygenic Risk Scores | |
| 880 | 8 | |6 505-00/(S |a Disease-Modifying Strategies: Models of Aβ Accumulation in Alzheimer's Disease-Implications for Aβ Amyloid-Targeting TherapiesReferences; 4 Neurodegeneration and the Ordered Assembly of Tau; Introduction; Tau Isoforms; Tau Aggregation; Genetics of MAPT; Propagation of Tau Aggregates; Strains of Aggregated Tau; Acknowledgments; References; Further Reading; 5 Amyotrophic Lateral Sclerosis and Other TDP-43 Proteinopathies; TDP-43 Biology; Amyotrophic Lateral Sclerosis; ALS-TDP-43; ALS-SOD1; ALS-FUS; ALS-C9ORF72; Mechanisms Dysregulated; Nucleocytoplasmic Transport; Proteostasis Clearance | |
| 880 | 8 | |6 505-00/(S |a Mitochondrial Energy ProductionRNA Metabolism; Axonal Dysfunction; Excitotoxicity; Oxidative Stress; Neuroinflammation; Other TDP-43 Proteinopathies; Frontotemporal Dementia; TDP-43 in Alzheimer's Disease and Parkinsonian Syndromes; Inclusion Body Myositis; Conclusions; References; 6 Parkinson's Disease and Other Synucleinopathies; Introduction: The Pathology of Parkinson's Disease; Protein Deposition; Aggregation of α-Synuclein in PD; The Broader Set of Synucleinopathies; Changes in Cellularity; Neuronal Loss; Reactive Gliosis; Genes Associated with Synucleinopathies | |