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Cell surface GRP78, a new paradigm in signal transduction biology /
'Cell Surface GRP78, a New Paradigm in Signal Transduction Biology' presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, United Kingdom :
Elsevier Ltd. : Academic Press,
[2018]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Cell Surface GRP78, a New Paradigm in Signal Transduction Biology; Copyright Page; Contents; List of Contributors; Preface; 1 An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology; Discovery of Cell Surface GRP78; GRP78 and Cancer Cell Biology; A Most Complex Signaling Mechanism; References; 2 The Endoplasmic Reticulum Chaperone GRP78 Also Functions as a Cell Surface Signaling Receptor; Introduction; Release of CS-GRP78 Into the Extracellular Environment; Secreted GRP78; GRP78 in Exosomes; Induction of GRP78 to the Cell Surface.
- CS-GRP78 Ligands and Their Cellular EffectsCS-GRP78 Forms Complexes With a Variety of Cell-Surface Anchored Proteins; CS-GRP78 Controls Key Oncogenic Signaling Pathways; Biological Functions of CS-GRP78 in Cancer; Cell Survival and Proliferation; Apoptosis; Invasion and Migration; Transcriptional Activation; Metabolism; The Role of CS-GRP78 in Other Physiological Diseases; Angiogenesis; Virus Internalization; Inflammation and Immunity; Arthritis; Therapeutic Targeting of CS-GRP78; GRP78 Autoantibodies and Their Physiological Roles; Concluding Remarks; References.
- 3 Cell Surface GRP78: Anchoring and Translocation Mechanisms and Therapeutic Potential in CancerIntroduction; Anchoring on the Cell Surface; Cell Surface Anchoring of ER-Transmembrane Chaperones; Cell Surface Anchoring of Peripheral Proteins; CS-GRP78 Binding Ligands, Membrane Proteins and Functions; Translocation Mechanisms; Intrinsic Factors; Protein-Protein Interaction in GRP78 Translocation; Trafficking Routes; Therapeutic Potential in Cancer; Antibodies; Peptide Conjugates; Proapoptotic Ligands; Conclusions and Perspectives; References.
- 4 Cell Surface GRP78: A Novel Regulator of Tissue Factor Procoagulant ActivityThe 78 kDa Glucose-Regulated Protein (GRP78); GRP78 Protein Structure; Translocation of GRP78 to the Cell Surface; Regulating the Levels of Cell Surface GRP78; Nonchaperone Functions of GRP78; Ca2+ Binding Protein; GRP78 and Pathology; Anti-GRP78 Autoantibodies and Cancer; GRP78 and the Coagulation System; Tissue Factor; The Role of Tissue Factor in Hemostasis; Tissue Factor Structure; Tissue Factor and Disease; Regulation of Tissue Factor Activity; Tissue Factor Dimerization; Altered Phospholipid Asymmetry.
- Tissue Factor Compartmentalization in CaveolaeTissue Factor Disulfide Bond Isomerization; Regulation of Tissue Factor by Cell Surface GRP78; Implication of TF Activation via Cell Surface GRP78 in Cancer; Conclusion; References; 5 Novel Cell Surface Targets for the Plasminogen Activating System in the Brain: Implications for Human Disease; Introduction; The Voltage-Dependent Anion Channel 1; Functions of Voltage-Dependent Anion Channel; The Plasminogen Activator System in the Brain; GRP78 and VDAC in the Brain; The Voltage-Dependent Anion Channel and Beta-Amyloid Peptides.