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|a (OCoLC)1029302290
|z (OCoLC)1021883116
|z (OCoLC)1022553113
|z (OCoLC)1022831352
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|b .P695 v.154eb
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|a SCI
|x 013040
|2 bisacsh
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|a 547.75
|2 23
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| 245 |
0 |
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|a Sirtuins in Health and Disease /
|c edited by Weiping Zheng.
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| 264 |
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1 |
|a Amsterdam :
|b Academic Press,
|c 2018.
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| 300 |
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|a 1 online resource (x, 176 pages) :
|b illustrations
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| 336 |
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|a text
|b txt
|2 rdacontent
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|b c
|2 rdamedia
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|a online resource
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|a Text in English.
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|a Intro; Title page; Table of Contents; Copyright page; Contributors; Preface and Ganglioside Nomenclature; Preface; Ganglioside Nomenclature; Chapter One: Ganglioside Metabolism in Health and Disease; Abstract; 1. Introduction; 2. Anabolism of gangliosides; 3. Anabolism and disease; 4. Catabolism; 5. Catabolism of gangliosides; 6. Regulation of ganglioside catabolism; Acknowledgment; Abbreviations; Chapter Two: Congenital Disorders of Ganglioside Biosynthesis; Abstract; 1. Introduction; 2. GM2/GD2 synthase deficiencies (B4GALNT1 mutations) in human disease.
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|a 3. GM3 synthase deficiencies (ST3GAL5 mutations) in human disease4. Perspectives; Chapter Three: Gangliosides in Membrane Organization; Abstract; 1. Chemical structure of gangliosides; 2. Physicochemical properties of gangliosides: a driving force for membrane organization; 3. Local modulation of membrane ganglioside composition: a mechanism for the fine tuning of membrane lateral organization; 4. Changes of ganglioside-driven membrane organization as a pathogenetic mechanism; 5. Conclusions; Chapter Four: Biological and Pathological Roles of Ganglioside Sialidases; Abstract; 1. Introduction.
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|a 2. Biological roles of ganglioside sialidases3. Pathological roles of ganglioside sialidases; 4. Concluding remarks; Chapter Five: Biology of GM3 Ganglioside; Abstract; 1. Introduction; 2. Molecular biology of GM3S/ST3GAL5; 3. Insulin resistance in adipocytes and macrophages; 4. Leptin signaling and resistance in hypothalamus; 5. T-cell immunity and immune disorders; 6. GM3S deficiency and hearing loss; 7. Conclusions and future directions; Acknowledgments; Chapter Six: Gangliosides in Cancer Cell Signaling; Abstract; Abbreviations; 1. Introduction; 2. Ganglioside biosynthesis and degradation.
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|a 3. Cellular and molecular biology of GTs and sialidases4. Regulation of cell signaling by gangliosides in cancer cells; 5. Gangliosides and apoptosis signaling; 6. Biological roles and relevance of sialidases in cancer; 7. Conclusions; Acknowledgments; Chapter Seven: Gangliosides in Diabetic Wound Healing; Abstract; 1. Introduction; 2. GM3 mediates insulin resistance in diabetes; 3. GM3 is a driver of impaired wound healing in type 2 diabetic mice; 4. The insulin/IGF1 signaling axis in diabetes and diabetic wounds; 5. Gangliosides regulate IGF1R signaling axis in cultured KCs; 6. Conclusions.
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| 650 |
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0 |
|a Sirtuins.
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| 650 |
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2 |
|a Sirtuins
|0 (DNLM)D037761
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| 650 |
|
7 |
|a SCIENCE
|x Chemistry
|x Organic.
|2 bisacsh
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| 650 |
|
7 |
|a Sirtuins
|2 fast
|0 (OCoLC)fst01763373
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| 700 |
1 |
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|a Zheng, Weiping,
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|t Sirtuins in Health and Disease.
|d Amsterdam : Academic Press, 2018
|z 0128122617
|z 9780128122617
|w (OCoLC)1007052648
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| 830 |
|
0 |
|a Progress in molecular biology and translational science ;
|v v. 154.
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| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/18771173/154
|z Texto completo
|
