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Vicinal diaryl substituted heterocycles : a gold mine for the discovery of novel therapeutic agents /
Vicinal Diaryl-Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents draws together all of the key information about these compounds in one place for the first time. Following an informative overview of the importance of these structures to the discovery of potential th...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
[2018]
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| Edición: | First edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Vicinal Diaryl Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents; Copyright; Contents; Contributors; Foreword; Preface; List of Abbreviations; Chapter 1: Vicinal Diaryl Heterocyclic System: A Privileged Scaffold in the Discovery of Potential Therapeutic Agents; 1.1 Brief Perspective of Heterocyclic Compounds; 1.2 Vicinal Diaryl-Substituted Heterocyclic Systems; 1.3 Importance of VDHS in the Discovery of Therapeutic Agents; 1.3.1 Clinically Used Drugs; 1.3.2 Therapeutically Potential Compounds; 1.3.2.1 Anticancer Agents; 1.3.2.2 COX-2 Inhibitors.
- 1.3.2.3 Antihypercholesterolemic Agents1.3.2.4 Antiviral Agents; 1.3.2.5 CB1 Receptor Antagonists; 1.3.2.6 Antimicrobial Agents; 1.3.2.7 Miscellaneous Agents; 1.4 Concluding Remarks; References; Chapter 2: Therapeutic Potential of Vicinal Diaryl Azetidin-2-ones; 2.1 Synthesis of Vicinal Diaryl Azetidin-2-Ones; 2.1.1 The Staudinger Reaction (Ketene�a#x80;#x93;Imine Reaction); 2.1.2 Enolate�a#x80;#x93;Imine Condensation Reaction; 2.1.3 The Mitsunobu Reaction; 2.2 Biological Spectrum of Vicinal Diaryl Azetidin-2-Ones; 2.2.1 Cholesterol Absorption Inhibitors; 2.2.2 Antiproliferative Agents.
- 2.2.3 Antimicrobial and Antitubercular Agents2.2.4 Anti-inflammatory and Analgesic Agents; 2.3 Conclusion; References; Chapter 3: Vicinal Diaryl Pyrroles: Synthesis and Biological Aspects; 3.1 Introduction; 3.2 Synthesis of Different Vicinal Diaryl Pyrroles; 3.3 Biological Spectrum of Vicinal Diaryl Pyrroles; 3.3.1 Antiproliferative Agents; 3.3.1.1 1,2-Diarylpyrroles; 3.3.1.2 2,3-Diarylpyrroles; 2,3-Diarylpyrroles as ER Binding Agents; 3.3.1.3 3,4-Diarylpyrroles; 3,4-Diarylpyrroles as VEGF-R Inhibitors; 3.3.1.4 4,5-Diarylpyrroles; 3.3.1.5 1,5-Diarylpyrroles.
- 3.3.2 Anti-inflammatory Agents/COX-2 Inhibitors3.3.2.1 1,5-Diarylpyrroles; 1,5-Diarylpyrroles as EP1 Receptor Antagonists; 3.3.3 Antitubercular Agents; 3.3.3.1 3,4-Diarylpyrroles; 3.3.3.2 1,5-Diarylpyrroles; 3.3.4 Anticoccidial Agents; 3.3.4.1 2,3-Diarylpyrroles; 3.3.5 1,5-Diarylpyrroles as Carbonic Anhydrase IX (hCA IX) Inhibitors; 3.4 Conclusion; References; Chapter 4: Synthesis and Biological Profiles of 4,5-, 1,5-, and 1,2-Diaryl-1H-imidazoles; 4.1 Introduction; 4.2 4,5-Diaryl-1H-Imidazoles; 4.2.1 Synthetic Methods.
- 4.2.2 Biological and Pharmacological Properties of 4,5-Diaryl-1H-imidazoles4.2.2.1 Anticancer Agents; Cytotoxic Compounds; Cytotoxic Compounds with Antivascular Effects; Cytotoxic Compounds with Tubulin Inhibitory Activity; Indoleamine 2,3-Dioxygenase Inhibitors; 4.2.2.2 Inhibitors of Transforming Growth Factor-�I² Type 1 Receptor (ALK5) Kinase; 4.2.2.3 Anti-inflammatory Agents; Selective Cyclooxygenase-2 (COX-2) Inhibitors; p38 MAP Kinase Inhibitors; 4.2.2.4 Inhibitors of Casein Kinase 1�I� (CK1�I�) and Dual Inhibitors of CK1�I� and p38 MAPK.