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Biomedical applications of functionalized nanomaterials : concepts, development and clinical translation /
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
[2018]
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| Colección: | Micro & nano technologies.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Biomedical Applications of Functionalized Nanomaterials; Biomedical Applications of Functionalized Nanomaterials; Copyright; Contents; List of Contributors; Preface; REFERENCES; 1
- From the �a#x80;#x9C;Magic Bullet�a#x80;#x9D; to Advanced Nanomaterials for Active Targeting in Diagnostics and Therapeutics; 1. PAUL EHRLICH AND THE �a#x80;#x9C;MAGIC BULLET�a#x80;#x9D;; 2. PASSIVE VERSUS ACTIVE TARGETING IN CANCER AS MODEL; 2.1 SUGARS; 2.2 TRANSFERRIN AND LACTOFERRIN; 2.3 FOLIC ACID; 2.4 HYALURONIC ACID; 2.5 ANTIBODIES; 2.6 APTAMERS; 3. EMERGING CHALLENGES AND PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES.
- I
- Ligand Selection and Functionalization of Nanomaterials2
- Conjugation Chemistry Principles and Surface Functionalization of Nanomaterials; 1. CONJUGATION CHEMISTRY IN THE CONTEXT OF BIOMEDICAL NANOMATERIALS; 2. CONJUGATION CHEMISTRY PRINCIPLES; 2.1 AMINE REACTIONS; 2.1.1 Amide Bond Formation: Strategies; 2.1.1.1 Acyl Halides; 2.1.1.2 Acyl Azides; 2.1.1.3 Acylimidazoles; 2.1.1.4 Anhydrides; 2.1.1.5 O-Acylisourea Using Carbodiimides as Coupling Reagents; 2.1.1.6 Active Esters; 2.1.1.7 Staudinger Ligation; 2.1.1.8 Microwave Activation; 2.1.2 Phosphoramidate Formation: Strategies.
- 2.2 THIOL REACTIONS2.2.1 Thioether Bond Formation: Addition of Thiols at Multiple Bonds of Unsaturated Compounds; 2.2.2 Disulfide Bridge; 2.3 HYDROXYL REACTIONS; 2.3.1 Ester Bond Formation: Strategies; 2.3.1.1 Acyl Halides, Anhydrides, and O-Acylisoureas via Carbodiimide Coupling; 2.3.1.2 Mitsunobu Coupling; 2.3.2 Carbamate Linkage Formation: Strategies; 2.4 CARBOXYLIC ACID REACTIONS; 2.5 ALDEHYDES AND KETONES REACTIONS; 2.6 ALKENES AND ALKYNES; 2.6.1 Diels�a#x80;#x93;Alder Cycloaddition; 2.6.2 Click Chemistry; 2.6.2.1 Huisgen 1,3-Dipolar Azide�a#x80;#x93;Alkyne Cycloadditions; 2.7 PHOTOCHEMICAL REACTIONS.
- 3. SELF-ASSEMBLED MONOLAYERS AS A POWERFUL TOOL FOR THE DESIGN OF�a#x80;�SURFACE-ENGINEERED NANOMATERIALS3.1 BIOMOLECULES CONJUGATION ONTO SELF-ASSEMBLED MONOLAYERS VIA COVALENT BINDING; 3.1.1 Maleimide-Terminated Self-Assembled Monolayers; 3.1.2 Alkyne or Azide-Terminated Self-Assembled Monolayers�a#x80;�(�a#x80;#x9C;Click Chemistry�a#x80;#x9D;); 3.1.3 Carboxylic Acid-Terminated Self-Assembled Monolayers; 3.1.4 Hydroxyl-Terminated Self-Assembled Monolayers; 3.2 BIOMOLECULES CONJUGATION ON SELF-ASSEMBLED MONOLAYERS VIA�a#x80;�AFFINITY BINDING; 4. CHALLENGES IN (BIO)CONJUGATION; REFERENCES.
- 3
- Phage Display Technology for Selection of Antibody Fragments1. INTRODUCTION; 2. ANTIBODY PHAGE DISPLAY LIBRARIES; 2.1 ANTIBODIES FROM NA�A#x8F;VE AND IMMUNE PHAGE DISPLAY LIBRARIES; 2.2 ANTIBODIES FROM SYNTHETIC AND SEMISYNTHETIC PHAGE DISPLAY LIBRARIES; 3. SELECTION AND SCREENING OF ANTIBODY PHAGE DISPLAY LIBRARIES; 4. ANTIBODY ENGINEERING; 4.1 AFFINITY MATURATION OF ANTIBODIES; 4.2 HUMANIZATION OF ANTIBODIES; 5. CONCLUSIONS AND FUTURE PERSPECTIVES; REFERENCES; 4
- Ribosome Display Technology for Selecting Peptide and Protein Ligands; 1. INTRODUCTION.