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Nanostructures for the engineering of cells, tissues and organs : from design to applications /
This title showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford, United Kingdom :
Elsevier,
[2018]
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| Colección: | Pharmaceutical nanotechnology series.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Nanostructures for the Engineering of Cells, Tissues and Organs; Copyright Page; Contents; List of Contributors; Series Preface: Pharmaceutical Nanotechnology; Preface; 1 Cell and organ drug targeting: Types of drug delivery systems and advanced targeting strategies; 1.1 Introduction; 1.2 Drug Targeting: What, Why and How?; 1.2.1 Definition and Reasons for Drug Targeting; 1.2.2 Drug Targeting Strategies; 1.2.2.1 Common approaches of targeted drug delivery; 1.2.2.1.1 Passive drug targeting; 1.2.2.1.2 Active drug targeting; 1.2.2.1.3 Other approaches�a#x80;#x99; classification.
- Combination targetingPhysical targeting; 1.2.2.2 Drug targeting systems; 1.2.2.2.1 Lipid-based nanosystems; Liposomes; Solid lipid nanoparticles; 1.2.2.2.2 Polymer-based nanosystems; Polymeric nanoparticles; Dendrimer nanocarriers; 1.2.3 Properties Influencing Drug Targeting; 1.2.3.1 Drug properties; 1.2.3.2 Carrier properties; 1.2.3.2.1 Physicochemical properties; Size; Shape (morphology/geometry); Surface characteristics; Composition and crystalline structure; 1.2.3.2.2 Functionalization and surface coating; 1.2.3.2.3 Aggregation and concentration.
- 1.2.3.3 Physiological and anatomical properties (biological barriers)1.3 Cellular Targeting: Normal Cells and Abnormal Cells; 1.4 Organ Targeting; 1.4.1 Drug Delivery to Brain; 1.4.1.1 Blood�a#x80;#x93;brain barrier: the most important barrier of drug delivery to the central nervous system; 1.4.1.2 Strategies to overcome the blood�a#x80;#x93;brain barrier; 1.4.2 Drug Delivery to Lung; 1.4.2.1 Advantages of pulmonary drug delivery; 1.4.2.2 Disadvantages of pulmonary drug delivery; 1.4.2.3 Anatomy and physiology of the lung; 1.4.2.4 Mechanism involved in deposition of particles in lung.
- 1.4.2.5 Drug delivery devices1.4.2.5.1 Metered dose inhalers; 1.4.2.5.2 Dry powder inhalers; 1.4.2.5.3 Nebulizers; 1.4.3 Drug Delivery to Eye; 1.4.3.1 Anatomy and physiology of the eye; 1.4.3.2 Classification of ocular drug delivery systems; 1.4.3.3 Route of ocular administration; 1.4.4 Drug Delivery to Neoplastic Disease; 1.5 Conclusion; Glossary; Abbreviations; References; 2 Cell-penetrating peptides in nanodelivery of nucleic acids and drugs; 2.1 Introduction; 2.1.1 Cationic Cell-Penetrating Peptides; 2.1.2 Amphipathic and Hydrophobic Cell-Penetrating Peptides.
- 2.2 Applications of Cell-Penetrating Peptides in Delivery of Therapeutic Molecules2.2.1 Delivery of Drugs and Proteins; 2.2.2 Delivery of Nucleic Acids; 2.2.2.1 Delivery of plasmid DNA; 2.2.2.2 Delivery of RNA interference molecules; 2.3 Discovery and Design of Novel Cell-Penetrating Peptides; 2.4 Cell-Penetrating Bacterial Effector Proteins as Novel Tools; 2.5 Recombinant Production of Cell-Penetrating Peptides for the Delivery Purpose; 2.6 Conclusion and Future Respects; Acknowledgments; References.