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180220s2018 enk ob 001 0 eng d |
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|a 1039685827
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|a 9780128136669
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|a 0128136669
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|z 9780128136652
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|z (OCoLC)1039685827
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|a Nanostructures for the engineering of cells, tissues and organs :
|b from design to applications /
|c edited by Alexandru Mihai Grumezescu.
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|a Oxford, United Kingdom :
|b Elsevier,
|c [2018]
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Pharmaceutical nanotechnology series
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|a Includes bibliographical references and index.
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|a Vendor-supplied metadata.
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|a Front Cover; Nanostructures for the Engineering of Cells, Tissues and Organs; Copyright Page; Contents; List of Contributors; Series Preface: Pharmaceutical Nanotechnology; Preface; 1 Cell and organ drug targeting: Types of drug delivery systems and advanced targeting strategies; 1.1 Introduction; 1.2 Drug Targeting: What, Why and How?; 1.2.1 Definition and Reasons for Drug Targeting; 1.2.2 Drug Targeting Strategies; 1.2.2.1 Common approaches of targeted drug delivery; 1.2.2.1.1 Passive drug targeting; 1.2.2.1.2 Active drug targeting; 1.2.2.1.3 Other approaches�a#x80;#x99; classification.
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|a Combination targetingPhysical targeting; 1.2.2.2 Drug targeting systems; 1.2.2.2.1 Lipid-based nanosystems; Liposomes; Solid lipid nanoparticles; 1.2.2.2.2 Polymer-based nanosystems; Polymeric nanoparticles; Dendrimer nanocarriers; 1.2.3 Properties Influencing Drug Targeting; 1.2.3.1 Drug properties; 1.2.3.2 Carrier properties; 1.2.3.2.1 Physicochemical properties; Size; Shape (morphology/geometry); Surface characteristics; Composition and crystalline structure; 1.2.3.2.2 Functionalization and surface coating; 1.2.3.2.3 Aggregation and concentration.
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|a 1.2.3.3 Physiological and anatomical properties (biological barriers)1.3 Cellular Targeting: Normal Cells and Abnormal Cells; 1.4 Organ Targeting; 1.4.1 Drug Delivery to Brain; 1.4.1.1 Blood�a#x80;#x93;brain barrier: the most important barrier of drug delivery to the central nervous system; 1.4.1.2 Strategies to overcome the blood�a#x80;#x93;brain barrier; 1.4.2 Drug Delivery to Lung; 1.4.2.1 Advantages of pulmonary drug delivery; 1.4.2.2 Disadvantages of pulmonary drug delivery; 1.4.2.3 Anatomy and physiology of the lung; 1.4.2.4 Mechanism involved in deposition of particles in lung.
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|a 1.4.2.5 Drug delivery devices1.4.2.5.1 Metered dose inhalers; 1.4.2.5.2 Dry powder inhalers; 1.4.2.5.3 Nebulizers; 1.4.3 Drug Delivery to Eye; 1.4.3.1 Anatomy and physiology of the eye; 1.4.3.2 Classification of ocular drug delivery systems; 1.4.3.3 Route of ocular administration; 1.4.4 Drug Delivery to Neoplastic Disease; 1.5 Conclusion; Glossary; Abbreviations; References; 2 Cell-penetrating peptides in nanodelivery of nucleic acids and drugs; 2.1 Introduction; 2.1.1 Cationic Cell-Penetrating Peptides; 2.1.2 Amphipathic and Hydrophobic Cell-Penetrating Peptides.
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|a 2.2 Applications of Cell-Penetrating Peptides in Delivery of Therapeutic Molecules2.2.1 Delivery of Drugs and Proteins; 2.2.2 Delivery of Nucleic Acids; 2.2.2.1 Delivery of plasmid DNA; 2.2.2.2 Delivery of RNA interference molecules; 2.3 Discovery and Design of Novel Cell-Penetrating Peptides; 2.4 Cell-Penetrating Bacterial Effector Proteins as Novel Tools; 2.5 Recombinant Production of Cell-Penetrating Peptides for the Delivery Purpose; 2.6 Conclusion and Future Respects; Acknowledgments; References.
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|a This title showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries.
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650 |
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|a Bioengineering.
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650 |
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0 |
|a Nanostructures.
|
650 |
1 |
2 |
|a Nanostructures
|0 (DNLM)D049329
|
650 |
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2 |
|a Biotechnology
|0 (DNLM)D001709
|
650 |
|
6 |
|a Biotechnologie.
|0 (CaQQLa)201-0004007
|
650 |
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6 |
|a Nanostructures.
|0 (CaQQLa)201-0232666
|
650 |
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7 |
|a bioengineering.
|2 aat
|0 (CStmoGRI)aat300250623
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650 |
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7 |
|a SCIENCE
|x Chemistry
|x Industrial & Technical.
|2 bisacsh
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650 |
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7 |
|a TECHNOLOGY & ENGINEERING
|x Chemical & Biochemical.
|2 bisacsh
|
650 |
|
7 |
|a Bioengineering
|2 fast
|0 (OCoLC)fst00832028
|
650 |
|
7 |
|a Nanostructures
|2 fast
|0 (OCoLC)fst01032635
|
655 |
|
4 |
|a Internet Resources.
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655 |
|
4 |
|a Charts.
|
700 |
1 |
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|a Grumezescu, Alexandru Mihai,
|e editor.
|
830 |
|
0 |
|a Pharmaceutical nanotechnology series.
|
856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780128136652
|z Texto completo
|