Systems biology and its application in TCM formulas research /

Systems Biology and Its Application in TCM Formulas Research presents a theoretical research system formed for Traditional Chinese Medicine (TCM) formulas, along with information on the study of Shexiang Baoxin Pill (SBP), a TCM formula that has shown significant clinical efficacy in the treatment o...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Zhang, Wei-Dong (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic Press, [2018]
Temas:
Medicine, Chinese > Formulae, receipts, prescriptions > Research.
Medicine, Chinese > Research.
Systems biology.
Medicine, Chinese.
Medicine, Chinese Traditional
Drug Compounding
Materia Medica
Systems Biology
M�edecine chinoise > Formules et recettes > Recherche.
M�edecine chinoise > Recherche.
Biologie syst�emique.
M�edecine chinoise.
MEDICAL > Pharmacology.
Medicine, Chinese
Medicine, Chinese > Research
Systems biology
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Section 1. Ideas and methods for the modern research of TCM formulas. Chapter 1. Strategy for modern research of traditional Chinese medicine formulae
  • Chapter 2. Theories and methods for the evaluation of the pharmacodynamic material basis of traditional Chinese medicine
  • Chapter 3. Application of systems biology in the research of TCM formulae
  • Chapter 4. Network pharmacology in the study of TCM formulae
  • Chapter 5. Application of intestinal flora in the study of TCM formulae
  • Chapter 6. Application of connectivity map (CMAP) database to research on traditional Chinese medicines (TCMs)
  • Section 2. Case study on Shexiang Baoxin pill. Chapter 7. The study of the material basis of the Shenxiang Baoxin pill
  • Chapter 8. Study on the serum pharmacochemistry of the Shenxiang Baoxin pill
  • Chapter 9. The quality study of the Shenxiang Baoxin pill
  • Chapter 10. Pharmacokinetic study of the Shenxiang Baoxin pill
  • Chapter 11. The metabolomics study of the Shenxiang Baoxin pill
  • Chapter 12. Network phramacology study of the Shenxiang Baoxin pill.
  • Front Cover; Systems Biology and its Application in TCM Formulas Research; Copyright; Contents; Contributors; Introduction; Section 1: Ideas and Methods for the Modern Research of TCM Formulas; Chapter 1: Strategy for Modern Research of Traditional Chinese Medicine Formulae; 1.1. Current Research on TCM Formulae; 1.2. Principles for the Study of TCM Formulae; 1.2.1. Holism and Reductionism; 1.2.2. Macro- and Microstudies; 1.2.3. In Vitro and in vivo Studies; 1.3. Modern TCM Formulae Research; 1.3.1. Research on Therapeutic Materials Basis; 1.3.2. Modern Pharmacology
  • 1.3.2.1. Top-Down: Holistic Pharmacology and Active Components Screening1.3.2.2. Bottom-Up: Pharmacological Evaluation of Key Active Components and Multicomponent Compatibility; 1.3.3. Systems Biology; 1.3.3.1. Genomics; 1.3.3.2. Proteomics; 1.3.3.3. Metabolomics; 1.3.3.4. Epigenomics; 1.3.3.5. Metagenomics; 1.4. Network Biology and TCM Network Pharmacology; References; Chapter 2: Theories and Methods for the Evaluation of the Pharmacodynamic Material Basis of Traditional Chinese Medicine; 2.1. The Development of Research on the Pharmacodynamic Material Basis of TCM
  • 2.2. New Methods for the Study of the Pharmacodynamic Material Basis of TCM2.2.1. Combined Chemical Technologies for the Study of TCM; 2.2.2. Serum Pharmacology and Serum Pharmacochemistry Method; 2.2.3. Analysis of Spectrum-Effect Relationships; 2.2.4. HTS of Multiple Targets; 2.2.5. Molecular Biological Chromatography Technique; 2.2.6. Metabolism Method; 2.2.7. System Biology Method; References; Chapter 3: Application of Systems Biology in the Research of TCM Formulae; Abstract; Keywords; 3.1. Omics in Systems Biology; 3.1.1. Genomics; 3.1.1.1. Pharmacogenomics; 3.1.1.2. Metagenomics
  • 3.1.1.3. Epigenomics3.1.2. Transcriptomics; 3.1.3. Proteomics; 3.1.3.1. Phosphoproteomics; 3.1.3.2. Glycoproteomics; 3.1.3.3. Chemoproteomics; 3.1.4. Metabolomics; 3.1.4.1. Pharmacometabolomics; 3.1.4.2. Lipidomics; 3.1.5. Other �a#x80;#x9C;Omics�a#x80;#x9D; Technologies; 3.1.5.1. Phenomics; 3.1.5.2. Immunomics; 3.1.5.3. Metallomics; 3.1.5.4. Cytomics; 3.1.5.5. Ionomics; 3.1.5.6. Interactomics; 3.2. Application of Systems Biology in the Research of TCM Formulae; 3.2.1. Action Mechanisms of TCM Formulae; 3.2.2. The Concept of a Syndrome in TCM; 3.2.3. Active Component Compatibility (or Synergy) in TCM Formulae
  • 3.2.4. Pharmacokinetic Studies of TCM Formulae3.2.5. Discovery and Development of TCM-Based New Drugs; References; Chapter 4: Network Pharmacology in the Study of TCM Formulae; 4.1. Identification of Therapeutically Effective TCM Compounds; 4.2. Identification of the Targets of Active TCM Compounds; 4.2.1. Proteomic Technologies; 4.2.2. Computational Predictions; 4.2.3. Database Searching; 4.3. Identification of Disease-Associated Genes and Construction of Disease-Related Networks; 4.3.1. Identification of Disease-Associated Genes; 4.3.2. Construction of Disease Networks

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