Cargando…
Forkhead FOXO transcription factors in development and disease /
Forkhead FOXO Transcription Factors in Development and Disease, Volume 127, the latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease. Each chapter is contributed b...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press, an imprint of Elsevier,
2018.
|
| Edición: | First edition. |
| Colección: | Current topics in developmental biology ;
v. 127. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Forkhead FOXO Transcription Factors in Development and Disease; Copyright; Contents; Contributors; Preface; Chapter One: DAF-16: FOXO in the Context of C. elegans; 1. Introduction; 2. Identification of daf-16; 2.1. Genetic; 2.2. Molecular; 3. Isoforms; 4. Direct Phosphorylation; 4.1. AKT-1/AKT-2/SGK-1; 4.2. Jun Kinase; 4.3. AMP Kinase; 5. Cofactors/Interacting Proteins; 5.1. NHL-1; 5.2. SWI/SNF; 5.3. 14-3-3 Proteins; 5.4. SMK-1; 5.5. STK4/CST-1; 6. Additional Inputs; 6.1. Heat Shock Factor-1; 7. Target Genes; 8. Conclusion; Acknowledgments; References
- Chapter Two: Stem Cells Seen Through the FOXO Lens: An Evolving Paradigm1. FOXO and Stem Cells; 2. FOXO in Embryonic Stem Cells and Development; 3. FOXO in Adult Tissue-Specific Stem Cells; 4. FOXO in Hematopoietic Stem Cells; 4.1. FOXO3, Reactive Oxygen Species, and Mitochondria in HSC; 4.2. FOXO and Autophagy in HSC; 4.3. FOXO and DNA Damage Response in HSC; 4.4. FOXO, mTOR, and Myeloproliferation; 4.5. FOXO and Leukemic Stem Cells; 4.6. FOXO, HSC Longevity, and the Role of Sirtuins and miRNAs; 5. FOXO and Neural Stem Cells; 6. FOXO3 and Muscle Stem Cells; 7. Concluding Remarks
- AcknowledgmentsReferences; Chapter Three: FOXOs Maintaining the Equilibrium for Better or for Worse; 1. Introduction: FOXO Regulation Getting up to Par; 2. The PI3K/PKB(AKT)/FOXO Signaling Pathway and Cancer; 3. FOXOs and the Hallmarks of Cancer; 3.1. FOXOs and the Hallmarks: Sustaining Proliferative Signaling; 3.2. FOXOs and the Hallmarks: Resisting Cell Death; 3.3. FOXOs and the Hallmarks: Enabling Replicative Immortality; 3.4. FOXOs and the Hallmarks: Inducing Angiogenesis; 3.5. FOXOs and the Hallmarks: Activating Invasion and Metastasis
- 3.6. FOXOs Genuine or ""Bona Fide"" Tumor Suppressor3.7. FOXOs: Tumor Suppressors or Promoters?; 4. FOXOs as Rheostats in Homeostasis; 4.1. Redox; 4.2. DNA Damage Response; 4.3. Protein Homeostasis; 5. FOXOs and Resistance to Therapy; 5.1. Quiescence as a Mechanism of Resistance; 5.2. The Role of Feedback Signaling in Acquiring Resistance; 5.3. Cross Talk With Other Pathways; 6. Conclusion; References; Further Reading; Chapter Four: FOXO in Neural Cells and Diseases of the Nervous System; 1. Introduction; 2. Neural Development and Stem Cell Maintenance
- 3. Neuronal Survival and Stress Responses4. Phenotypic Consequences of FOXO Loss; 5. Neurodegenerative Disease; 6. Future Directions; References; Further Reading; Chapter Five: Regulation of Hepatic Glucose Metabolism by FoxO Proteins, an Integrated Approach; 1. Overview; 2. Early Studies and Early Insights; 3. Regulation of FoxO Function by Insulin/PI3K/Akt Signaling and Deacetylases; 4. Effects on Gluconeogenic Gene Expression; 5. Effects on Glycolysis and Glucose Utilization; 6. Effects of Fatty Acid Oxidation on Glycolysis and Gluconeogenesis