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International review of cell and molecular biology. Volume 336 /
International Review of Cell and Molecular Biology. Volume 336 reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cel...
| Clasificación: | Libro Electrónico |
|---|---|
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press,
2018.
|
| Edición: | First edition. |
| Colección: | International Review of Cell and Molecular Biology ;
Volume 336 |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro; Title page; Table of Contents; Copyright; Contributors; Chapter One: Membrane Trafficking in Autophagy; Abstract; 1 Introduction; 2 Autophagy; 3 Membrane Trafficking; 4 Membrane Trafficking in Autophagosome Formation; 5 Autophagosome Maturation; 6 Autophagic Lysosome Reformation; 7 Noncanonical Autophagy; 8 Concluding Remarks; Acknowledgments; Chapter Two: Altered Metabolism of Leukemic Cells: New Therapeutic Opportunity; Abstract; 1 Introduction; 2 Leukemia Classification; 3 Current Therapy; 4 Metabolism of Normal Hematopoietic vs Leukemic Cells; 5 Glucose Metabolism
- 6 Oxidative Phosphorylation7 Tricarboxylic Acid Cycle: Isocitrate Dehydrogenase; 8 Lipid Metabolism; 9 Amino Acid Metabolism; 10 Concluding Remarks; Acknowledgments; Chapter Three: Profiling Celiac Disease-Related Transcriptional Changes; Abstract; 1 Celiac Disease; 2 Microarray Studies; 3 RNA-Seq Studies; 4 miRNA Expression; 5 Disease Association and Function: Expression Quantitative Trait Loci; 6 CD Variants in Noncoding Regions; Chapter Four: Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer; Abstract; 1 Introduction; 2 IDO1 in Immune Escape From T Cell Immunity
- 3 IDO1 in Inflammatory Programming: MDSC Development and Metastasis4 IDO1 in Inflammatory Programming: Pathogenic Neovascularization and Metastasis; 5 IDO2 in B-Cell Inflamed States and Certain IDO1 Functions: Connections and Questions; 6 TDO in Inflammatory Programming: Immune Escape, Anoikis Resistance, and Metastasis; 7 Lead Clinical Agents: Indoximod, Epacadostat, and Navoximod; 8 Other IDO/TDO Inhibitor Clinical Candidates; Acknowledgments; Chapter Five: Loss of Nuclear Envelope Integrity in Aging and Disease; Abstract; 1 The Nuclear Envelope Safeguards Nuclear Compartmentalization
- 2 Nuclear Envelope Erosion Compromises Transport Selectivity3 Nuclear Envelope Shedding Bypasses NPC Control; 4 Nuclear Envelope Rupture Triggers Abhorrent Nucleocytoplasmic Exchange; 5 Conclusion; Acknowledgment; Chapter Six: Mechanisms of Cortical Differentiation; Abstract; 1 Introduction; 2 A Primer on Neocortical Anatomy; 3 Early Neocortical Development; 4 Control of Neocortical Neurogenesis; 5 Control of Neocortical Gliogenesis; 6 Conclusions and Future Perspectives; Acknowledgments
- Chapter Seven: New Insights Into Autophagy Dysfunction Related to Amyloid Beta Toxicity and Neuropathology in Alzheimer's DiseaseAbstract; 1 Introduction; 2 Autophagy and Its Machinery; 3 A�I² Biogenesis and AD-Related Toxicity; 4 Autophagy Dynamics and AD Pathogenesis; 5 APP and the Autophagosome: Site of Clearance and Site of Production; 6 A�I² Clearance and the Role of Autophagy in A�I² Homeostasis; 7 The Protein Signature of Autophagic Failure in AD; 8 Autophagy Control: Therapeutic Interventions in AD; 9 Summary and Future Directions; Acknowledgments